en Endocrine Physiology/Pharmacology Endocrine Physiology/Pharmacology Review Review <p><span style="font-size:12px;"><span style="font-family:Arial;">The advent of Coronavirus Disease 2019 (COVID-19), first identified in Wuhan, China, has led to significant mortality and morbidity worldwide, disproportionately affecting individuals with comorbidities such as diabetes mellitus (DM), cardiovascular diseases (CVDs), and obesity. Evidence suggests a strong correlation between DM and heightened risk of severe COVID-19 complications, which is thought to be exacerbated by factors such as hyperglycemia, systemic inflammation, immune dysregulation, and the increased expression of the angiotensin-converting enzyme 2 (ACE2) receptor in pancreatic cells. The interaction of COVID-19 with antidiabetic medications is complex, with varying reports on how these drugs may influence the disease trajectory in diabetic patients. This article seeks to synthesize the current literature on the role of antidiabetic agents in managing COVID-19 in patients with diabetes, elucidating their potential protective or adverse effects and providing a comprehensive overview of the evolving understanding of this critical interface.</span></span></p> COVID-19,Diabetic patients,Antidiabetic agents,COVID-19 outcomes 363 388 http://ppj.phypha.ir/browse.php?a_code=A-10-2231-1&slc_lang=en&sid=1 Malek Zarei m.zarei@sbmu.ac.ir 3200319475328460036813 000000030217439X Yes Shahid Beheshti University of Medical Sciences, Tehran, Iran Navideh Sahebi vaihan nsahebivaighan@bwh.harvard.edu 3200319475328460036814 3200319475328460036814 No Brigham and Women's Hospital, Boston, Massachusetts, United States Sepideh Shiravand sepidehshiravand3@gmail.com 3200319475328460036815 0000000272077539 No Shahid Beheshti University of Medical Sciences, Tehran, Iran Sara Mohammadvali-samani saramvsamani@yahoo.com 3200319475328460036816 3200319475328460036816 No Shahid Beheshti University of Medical Sciences, Tehran, Iran Mohammad Abbas Sheikholeslami mashaikhalagha@gmail.com 3200319475328460036817 0000000246244348 No Shahid Beheshti University of Medical Sciences, Tehran, Iran Zahra Roudbari poro72@gmail.com 3200319475328460036818 3200319475328460036818 No Shiraz University of Medical Sciences, Shiraz, Iran