en Cardiovascular Physiology/Pharmacology Cardiovascular Physiology/Pharmacology Review Review <span style="font-size:12px;"><span style="font-family:Arial;">Cardiovascular diseases (CVDs) are the leading cause of death in human societies. Several medicinal and interventional therapeutic approaches are approved for the treatment of CVDs, one of which is phytomedicine. Phytomedicine is described as the exploitation of the therapeutic properties of herbal medicines. The cardioprotective effects of phytochemicals are due to their anti-oxidative, anti-hypercholesterolemia, anti-inflammatory, antiangiogenic, and anti ischemic activities, reducing the risk factors of developing CVDs. Regenerative medicine (RM) is a well-established f ield that aims to replace, repair, and regenerate diseased and injured human cells, tissues, or organs. Stem cells&rsquo; (SC) potential to differentiate into various cell types and their self-renewal capabilities have made them an excellent tool for applying RM in CVD. The intersection of phytomedicines and regenerative medicine can be categorized into two main areas. Phytochemicals have been shown to significantly enhance the proliferation and differentiation of mesenchymal stem cells (MSCs). For example, certain plant extracts promote osteogenic (bone-forming) and chondrogenic (cartilage-forming) differentiation of MSCs, thereby enhancing stem cell function. Additionally, plant derived compounds can mitigate the side effects associated with conventional therapies while offering effective treatment options for tissue regeneration (natural alternatives to traditional therapeutics). This paper reviews current evidence and studies on the beneficial properties of phytomedicines in cardiac RM, both in animal models and in humans. In summary, all of the mentioned studies suggestthat the use of phytomedicine may be directly or indirectly involved in cardiogenesis and angiogenesis by stimulating endogenous SCs and their secretory activity, modulating cytokine release, signal transduction, and elevating the levels of several cardiac regeneration factors. On the other hand, various mechanisms through which these herbal medicines act, such as reducing oxidative stress, controlling inflammation, and promoting angiogenesis, underscore their potential as viable alternatives or adjuncts to conventional therapies for cardiovascular diseases. The integration of phytomedicine into clinical practice could lead to enhanced overall therapeutic efficacy, more effective and personalized treatment, fewer cardiovascular risks and better health outcomes. Further research is required to elucidate the specific molecular pathways through which phytomedicines exert their beneficial effects on cardiac tissue. Understanding these mechanisms will help in developing targeted therapies.</span></span> Phytomedicine, Regenerative medicine, Stem cells, Mesenchymal stem cells, Cardiac regeneration, Angiogenesis 350 374 http://ppj.phypha.ir/browse.php?a_code=A-10-2346-1&slc_lang=en&sid=1 Mohammad Sheibani mohammadsheibani89@gmail.com 3200319475328460038631 3200319475328460038631 No Razi Drug Research Center, School of Medicine, Iran University of Medical Sciences, Tehran, Iran Maryam Shayan maryamshayan99@gmail.com 3200319475328460038632 3200319475328460038632 No Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran Afrooz Mohammadgholi-Beiki afrooz.beygi@gmail.com 3200319475328460038633 3200319475328460038633 No Department of Pharmacology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran Amin Sharifi amin.sharifi@tum.de 3200319475328460038634 3200319475328460038634 No German Heart Centre Munich, Department of Cardiology, Technical University of Munich, Munich, Germany Majid Jafari-Sabet jafarisabet.m@iums.ac.ir 3200319475328460038635 0000000329625752 Yes Razi Drug Research Center, School of Medicine, Iran University of Medical Sciences, Tehran, Iran Ali Mohammad Sharifi sharifalim@gmail.com 3200319475328460038636 0000000250897122 No Razi Drug Research Center, School of Medicine, Iran University of Medical Sciences, Tehran, Iran