en Clinical Physiology/Pharmacology Clinical Physiology/Pharmacology Experimental research article Experimental research article <span style="font-size:12px;"><span style="font-family:Arial;"><strong>Introduction: </strong>Traditional medicine recommends herbal medicines for metabolic disorders. The present study explores the skin wound healing potential of Hypericum helianthemoides (H. helianthemoides) extract in diabetic and non-diabetic rats.<br /> <strong>Methods: </strong>Following wound induction in diabetic (n=50) (induced by a single dose of streptozotocin) and non-diabetic (n=50) rats, H. helianthemoides extract (5% and 10%) was administered versus standard drug phenytoin (1%) and Osrin to positive and sham control groups. Tropical ointment therapy was applied once a day until the end of the study period (20 days). A Vernier caliper (with a 0.1 mm accuracy) was used to measure the wound length at 1, 3, 7, 11, 15, and 20 days after induction. Furthermore, pathological examination categorized the wound healing process into five categories: poor, mild, moderate, fair, and excellent.<br /> <strong>Results:</strong> On the study&rsquo;s first day, both diabetic and nondiabetic rats had the same wound area size. After 11 days, the wound area size significantly decreased in groups treated with 5% and 10% H. helianthemoides extract compared to the sham and control groups (P<0.001). Hence, based on the wound pathological evaluation scale, the most frequent phenytoin and H. helianthemoides extract-treated groups were classified as moderate to excellent (P<0.05).<br /> <strong>Conclusion:</strong> H. helianthemoides extract accelerates full-thickness wound healing in diabetic and non-diabetic rats</span></span> Hypericum helianthemoides, Wound healing, Herbal medicine, Streptozotocin, Diabetes mellitus 389 399 http://ppj.phypha.ir/browse.php?a_code=A-10-2347-1&slc_lang=en&sid=1 Soheila Soltanbeigi ss.soheila@yahoo.com 3200319475328460038132 3200319475328460038132 No Department of Physiology, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran Zeinab Fahimi zeinab_fahimi@yahoo.com 3200319475328460038133 3200319475328460038133 No Department of Physiology, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran Maryam Maleki maryammaleki777@yahoo.com 3200319475328460038134 3200319475328460038134 No Department of Physiology, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran Aliashraf Mozafari amozafari99@yahoo.com 3200319475328460038135 3200319475328460038135 No Non-Communicable Diseases Center, Ilam University of Medical Sciences, Ilam, Iran Mohammad Reza Kaffashian kaffashian-mr@medilam.ac.ir 3200319475328460038136 000000015340690X Yes Department of Physiology, School of Medicine, Ilam University of Medical Sciences, Ilam, Iran