Physiology and Pharmacology
Physiol Pharmacol
Medical Sciences
http://ppj.phypha.ir
32
journal32
24765236
24765244
10.61186/phypha
(previous ISSN: 17350581)
en
jalali
1379
1
1
gregorian
2000
4
1
4
1
online
1
fulltext
en
نقش گیرنده های GABAB در بی دردی ایجاد شده توسط ایمی پرامین در مدل حیوانی درد نوروپاتیک
The role of GABAB receptors in imipramine-induced antinociception in experimental model of neuropathic pain
Nervous system (others)
Others
Experimental research article
Experimental research article
This study was designed to investigate the role of GABAB receptor agents on imipramine-induced antinociception in ligated and non-ligated mice using hot-plate test. The data showed that different doses of morphine (3, 6, and 9 mg/kg) induced a dose-dependent antinociception in ligated and non-ligated mice. However, the opioid response was decreased in ligated animals. Intracerebroventricular (i.c.v.) administration of imipramine (5, 10, 20, and 40 µg/mouse) did not induce antinociception in either non-ligated or ligated mice. However, the induced response in the ligated mice was less than that induced in the non-ligated mice. Intraperitoneal (i.p.) administration of imipramine (10, 20, 30, and 40 mg/kg) induced antinociception in both ligated and non-ligated mice. The responses to the drug were not significantly different in the two groups. Administration of baclofen either i.c.v. (0.125, 0.25, and 0.5 µg/mouse) or i.p. (0.5, 1,2, and 4 mg/kg) induced antinociception. The response to the drug was not significantly different in ligated and non-ligated mice. Intracerebroventricular administration of a lower dose of baclofen (0.125 µg/mouse) with different doses of imipramine (2.5, 5, and 10 mg/kg) potentiated the response to imipramine. This effect was reduced by i.c.v. injection of GABAB receptor antagonist, CGP35348 [P-(3-aminopropyl)-p-diethoxymethyl- phosphinic acid] at a dose of 20 µg/mouse. The higher dose of antagonist (20 µg /mouse) also decreased the response induced by baclofen or imipramine. CGP35348 itself (2.5, 5, 10, and 20 µg/mouse) induced a dose-dependent antinociception with no significant difference in the ligated and non-ligated mice. It is concluded that a GABA receptor mechanism(s) may modulate the antidepressant-induced antinociception.
Imipramine; Baclofen; CGP35348; Ligation; Neuropathic pain; Hot-plate test
85
94
http://ppj.phypha.ir/browse.php?a_code=A-10-73-124&slc_lang=en&sid=1
Sadegh
Valizadeh
3200319475328460011630
3200319475328460011630
Yes
Islamic Azad Univ- Noshar and Chalous Branch, Iran
Mohammad Reza
Zarrindast
3200319475328460011631
3200319475328460011631
No