en Cell, Stem Cell and Cancer Cell, Stem Cell and Cancer Experimental research article Experimental research article <p><span style="font-size:12px;"><span style="font-family:Arial;"><strong>Introduction: </strong>One of the most common cancers of the oral cavity is oral squamous cell carcinoma (OSCC). Previous studies have provided evidence that apolipoprotein C-I (Apo C-I) has an oncogenic role beyond its classical function. Although it has been investigated in prostate, breast, and lung cancer, there is no information available regarding Apo C-I expression in tumor and pri-tumor tissues of OSCC patients. Thus, the goal of the present study was to unravel the expression of Apo C-I in OSCC and investigate its correlation with the survival and grade of OSCC patients.<br /> <strong>Methods: </strong>The Apo C-I mRNA level was measured in tumor and pri-tumor tissues of 16 OSCC patients. In addition, the 34 paraffin-embedded tissues of OSCC patients and IHC technique were used to analyze the association of Apo C-I protein with the survival of OSCC patients.&nbsp;<br /> <strong>Results:</strong> The mRNA (P=0.0386) gene expression of Apo C-I showed a statistically significant difference between tumor and pri-tumor tissues of OSCC patients. It seems that a high protein level of Apo C-I is related with poor survival of OSCC patients (P=0.04). The Apo C-I protein was positively correlated with the tumor site (Pearson r= 0.485, P=0.0036) but not the grade (Pearson r= 0.2295, P=0.1917). Our data showed that high Apo C-I protein levels might be correlated with poor survival of OSCC patients.<br /> <strong>Conclusion: </strong>Our findings suggest that patients with high protein levels of Apo C-I may have lower survival, making it a potential prognostic factor for OSCC. However, further investigation is necessary to establish this concept.</span></span></p> Apolipoprotein C-I, Oral Squamous Cell Carcinoma, Survival 135 145 http://ppj.phypha.ir/browse.php?a_code=A-10-1718-1&slc_lang=en&sid=1 Kurosh Hamzanloui Moghadam kuroshmqdm75@gmail.com 3200319475328460037735 3200319475328460037735 No Department of Clinical Biochemistry, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran Walla Alazzawi hussain89abd@gmail.com 3200319475328460037736 3200319475328460037736 No Department of Clinical Biochemistry, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran Samira Derakhshan samderakhshan.den@gmail.com 3200319475328460037737 3200319475328460037737 No Oral and Maxillofacial Pathology Department, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran Abbas Karimi abkarimi@tums.ac.ir 3200319475328460037738 3200319475328460037738 No Oral and Maxillofacial Surgery Department, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran Zahra Shahsavari shahsavari.z@gmail.com 3200319475328460037739 3200319475328460037739 No Department of Clinical Biochemistry, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran Afsaneh Goudarzi afsaneh.goudarzi@hotmail.com 3200319475328460037740 3200319475328460037740 Yes Department of Clinical Biochemistry, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran