Physiology and Pharmacology
Physiol Pharmacol
Medical Sciences
http://ppj.phypha.ir
32
journal32
24765236
24765244
10.61186/phypha
(previous ISSN: 17350581)
en
jalali
1384
12
1
gregorian
2006
3
1
10
2
online
1
fulltext
en
Olanzapine antagonizes the acquisition and expression of morphine-induced conditioned place preference in male and female mice
Pain and addiction
Neurophysiology/Pharmacology
Experimental research article
Experimental research article
Introduction: Several investigations have indicated that dopamine D
receptors could influence morphine
2
eward. The influence of olanzapine (a D
dopamine receptor antagonist) on the morphine-induced conditioned
2
lace preference (CPP) in male and female mice was investigated in the present study.
Methods: The effects of olanzapine on the acquisition and expression of morphine CPP in male and female
-MRI mice (W: 20-25 g) were investigated in the present study.
Resultd: Subcutaneous (s.c.) injection of morphine (1-10 mg/kg, three drug sessions) induced place preference
oth in male and female mice. Intraperitoneal (i.p.) administration of olanzapine (0.5-5 mg/kg) induced place
version (CPA) in female mice but not in male mice. Administration of olanzapine (1, 2.5, 5 mg/kg, i.p.) reduced
oth the acquisition and expression of morphine-induced CPP in male and female mice. However, olanzapine (5
g/kg, i.p.) caused more than 80% mortality in female but not male mice. The effects of olanzapine were reversed
y L-arginine (20 mg/kg, i.p.) pre-administration.
Conlusion: We conclude that olanzapine reduced morphine effects via different mechanism/s.
Morphine; Olanzapine; Place preference; Nitric oxide; Mice.
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http://ppj.phypha.ir/browse.php?a_code=A-10-74-3&slc_lang=en&sid=1
Parivash
Hafez-Amini
320031947532846002918
320031947532846002918
No
Jamal
Shams
320031947532846002919
320031947532846002919
No
Ali
Shabahng-Saber-Tehrani
320031947532846002920
320031947532846002920
No
Ali
Haeri-Rohani
320031947532846002921
320031947532846002921
No
Kazem
Parivar
320031947532846002922
320031947532846002922
No
Vahab
Babapour
320031947532846002923
320031947532846002923
No
Hedayat
Sahraei
h.sahraei@bmsu.ac.ir
320031947532846002924
320031947532846002924
Yes