en Nervous system (others) Others Experimental research article Experimental research article Introduction: The claustrum interconnects with the allocortical and neocortical regions and also projects to the hippocampus and the amygdala. .The role of claustrum in the complex partial seizure is not clear. Thus in this study the effect of amygdala lesion on anterior claustrum kindled seizures in rat were investigated. Methods: Male Wistar rats, weighting 250-300 g, were received DC current via a bipolar electrode which is inserted in right basolateral amygdala. A tripolar electrode for stimulation and electroencephalography recording in the right anterior claustrum has been fixed. After a 10 days period of surgical recovery, animals were received kindling stimulation (60Hz, 2s, 1 ms pulse duration) daily, and kindling parameters were measured. In the control group animals did not receive DC current. In the lesion groups (2 groups) animals received DC current both before kindling stimulation and after full kindled statement respectively. Results: Our result showed that amygdala lesion, were capable of delaying claustrum kindling. The delay in kindling was due to an increase in the stimulation trials required to kindle to seizure stages. Furthermore the effect of this lesion on established kindled seizures reduced the severity of claustrum by decrease the stage 5 duration and after discharge duration. Conclusion: amygdale lesion had no effect on the expression of generalized seizures and claustrum play an important role in the propagation of epileptic seizure. Whereas the amygdala has a facilitators role in propagation claustrum kindled seizure. Anterior claustrum, kindling, Amygdala lesion. 312 319 http://ppj.phypha.ir/browse.php?a_code=A-10-161-1&slc_lang=en&sid=1 Fariba Zafari 1 320031947532846003359 No Neuroscience research center.Cellular and malecular research center Masome Sabetkasaei kasai@sbmu.ac.ir 2 320031947532846003360 Yes Neuroscience research center Yousef Sadeghi 3 320031947532846003361 No Cellular and malecular research center Mohammad Mohammad-zade 4 320031947532846003362 No Department od physiology,Tarbiat modares university. Fateme Deljo 5 320031947532846003363 No Pasture institute