Physiology and Pharmacology
Physiol Pharmacol
Medical Sciences
http://ppj.phypha.ir
32
journal32
24765236
24765244
10.22034
(previous ISSN: 17350581)
en
jalali
1377
8
1
gregorian
1998
11
1
2
2
online
1
fulltext
en
The effect of CCK receptor agonists and antagonists in sciatic nerve-ligated mice
Experimental research article
Experimental research article
<span style="FONT-SIZE: 12pt FONT-FAMILY: "Palatino Linotype" mso-fareast-font-family: 'Times New Roman' mso-bidi-font-family: 'Times New Roman' mso-ansi-language: EN-US mso-fareast-language: EN-US mso-bidi-language: AR-SA">The effects of caerulin, a CCK receptor agonist, and proglumide, a receptor antagonist, on hyperalgesia induced by sciatic nerve ligation, was studied in mice. Tolerance to the morphine response was obtained 3,7, 14,21 and 28 days after unilateral sciatic nerve ligation. Maximum hyperalgesia was found 14 days after nerve ligation. Caerulin increased morphine antinociception in nerve-ligated animals. The drug also induced antinociception in intact animals. Proglumide also induced antinociception in nerve-ligated mice. The antagonist increased the morphine response but did not alter the effect of caerulin. We conclude that the CCK receptor mechanism may have a role in hyperalgesia induced by nerve ligation</span>
Nerve ligation; Morphine; CCK receptor agents
128
136
http://ppj.phypha.ir/browse.php?a_code=A-10-110-77&slc_lang=en&sid=1