Physiology and Pharmacology
Physiol Pharmacol
Medical Sciences
http://ppj.phypha.ir
32
journal32
24765236
24765244
10.61186/phypha
(previous ISSN: 17350581)
en
jalali
1378
8
1
gregorian
1999
11
1
3
2
online
1
fulltext
en
The effect of intracerebroventricular administration of CCK receptor agonist and antagonist in nerve-Iigated mice
Experimental research article
Experimental research article
<span style="FONT-SIZE: 12pt FONT-FAMILY: "Palatino Linotype" mso-fareast-font-family: 'Times New Roman' mso-bidi-font-family: 'Times New Roman' mso-ansi-language: EN-US mso-fareast-language: EN-US mso-bidi-language: AR-SA">In the present study the effect of intracerebroventricular (ICV) injection of cerulein, an agonist of CCK receptor and proglumide, a receptor antagonist for hyperalgesia induced by sciatic nerve ligation were investigated in mice. Subcutaneous administration of morphine caused anti-nociception in both intact and nerve-ligated mice. However, the response to opioids was lower in ligated mice as compared to the intact animals. Cerulein induced antinociception only in the nerve-Iigated animals. Combination of cerulein with morphine elicited higher response in both intact and ligated animals. However, the induced response was much prominent in ligated animals. Proglumide alone did not elicit any response in both groups. The antagonist decreased the response of cerulein in the non-ligated mice. In addition a low dose of proglumide in combination with cerulein induced antinociception in the ligated mice. It can be concluded that CCK receptor-related </span>
Cerulein; Chronic pain; Ligation; Morphine tolerance; Proglumide
131
139
http://ppj.phypha.ir/browse.php?a_code=A-10-73-4&slc_lang=en&sid=1
Mohammad Reza
Zarrindas
320031947532846001894
320031947532846001894
Yes
Farzaneh
Samiie
320031947532846001895
320031947532846001895
No
Ali Akbar
Haeri Roohani
320031947532846001896
320031947532846001896
No
Seyed Mahdi
Rezayat
320031947532846001897
320031947532846001897
No