Physiology and Pharmacology
Physiol Pharmacol
Medical Sciences
http://ppj.phypha.ir
32
journal32
24765236
24765244
10.61186/phypha
(previous ISSN: 17350581)
en
jalali
1378
8
1
gregorian
1999
11
1
3
2
online
1
fulltext
en
Studying the effects of pH and molecular charge on the passive and iontophoretic permeation of L-phenylalanine through cellulose acetate membrane
Experimental research article
Experimental research article
<p> Iontophoresis is one of the skin permeation enhancement methods involving the transport of drugs through the skin under the effect of electrical current. The effect of molecular charge on the iontophoretic permeation of drugs has not been completely understood yet. Therefore the effect of passive and iontophoretic permeation of L-phenylalanine at pH 3.6 (positive charge) and pH 8 (negative charge) with the same charge concentrations was studied through cellulose acetate membrane (CA). The results revealed that there is a significant difference (p = 0.025) between passive (0.92 ± 0.11 mg/cm<sup>2</sup>/hr) and iontophoretic (1.08 ± 0.07 mg/cm<sup>2</sup>/hr) fluxes at pH 3.6. However, there was no difference (p = 0.208) between passive (1.06 ± 0.11 mg/cm<sup>2</sup>/hr) and iontophoretic (1.13 ± 0.12 mg/cm<sup>2</sup>/hr) fluxes at pH 8. This should be due to the presence of electroosmotic flow at pH 8, which its direction is opposite to that of ions that are moving under the direct effect of the electrical current. These results are in agreement with our previous data and show that CA can model the effects of electroosmotic flow on the iontophoretic permeation of drugs through the skin. Our investigations also show that efficiency of iontophoresis for positive and negative ions are different practically. The results also indicate that there is no difference between fluxes at pH 3.6 and 8 in either passive (p = 0.119) or iontophoretic (p = 0.499) methods. These data are opposite to that of our previous results that showed the fluxes at pH 3.6 are significantly less than that of pH 8 in both methods. This should be due to charge and size-dependent differences of skin and CA and imply that CA can not quantitatively model the skin barrier in this regard. </p>
Cellulose acetate membrane; Enhancement; Iontophoresis; Molecular charge; Percutaneous absorption; Phenylalanine
153
161
http://ppj.phypha.ir/browse.php?a_code=A-10-112-2&slc_lang=en&sid=1
Ali
Moghimi
320031947532846001900
320031947532846001900
Yes
Fatemeh
Talaie
320031947532846001901
320031947532846001901
No
Masoud
Adarangi
320031947532846001902
320031947532846001902
No