Physiology and Pharmacology
Physiol Pharmacol
Medical Sciences
http://ppj.phypha.ir
32
journal32
24765236
24765244
10.61186/phypha
(previous ISSN: 17350581)
en
jalali
1387
2
1
gregorian
2008
5
1
12
1
online
1
fulltext
en
The role of adenosine A2 receptors in regulation of pial vessels blood flow in anesthetized morphine dependent rats.
Cardiovascular Physiology/Pharmacology
Cardiovascular Physiology/Pharmacology
Experimental research article
Experimental research article
Introduction:Adenosine as a potent vasodilator has physiological role in regulation of regional cerebral blood flow (rCBF).
Metod: Laser-DŁoppler flowmetry technique was used to study pial vessels blood flow responses to adenosine receptors agonists and antagonist. Male Sprague Dawley rats (250-350g) that were housed in standard conditions, were anesthetized with Urethane (1.5g/kg). Adenosine (general agonist), NECA (A2Aand A2B receptor agonist) and CGS-21380(A2Aselective agonist), were used in absence and presence of A2A receptors- selective antagonist, ZM-243185, in naive and morphine-dependent rats.
Results: Adenosine, NECA and CGS-21680 increased pial vessels blood flow in naive and dependent rats dose dependently. These responses were blocked significantly by ZM-243185. Responses of pial vessels to adenosine (10-4, 10-5, 10-6 M) and NECA (10-4, 10-5, 10-6 M) were increased significantly in morphine- dependent rats in comparison to naive rats. Pial vessels responses to CGS-21680 had not shown any significant deferences between morphine- dependent and naive rats.
Conclusion:Based on these results it could be concluded that the role of A2B receptors in regulation of rCBF in morphine-dependent rats is more effective than A2A receptors.
Adenosine receptors, morphine-dependence, pial vessels blood flow.
22
30
http://ppj.phypha.ir/browse.php?a_code=A-10-175-2&slc_lang=en&sid=1
Marzeieh
Hoseini
320031947532846003759
320031947532846003759
No
Tarbiat Modares university
Sohrab
Hajizadeh
hajizads@modares.ac.ir
320031947532846003760
320031947532846003760
Yes
Tarbiat Modares university
yaghoub
Fathollahi
320031947532846003761
320031947532846003761
No
Tarbiat Modares university
Mojtaba
Golmohammadi
320031947532846003762
320031947532846003762
No
Batoul
Erfani
320031947532846003763
320031947532846003763
No
Ali
Heidarian Pour
320031947532846003764
320031947532846003764
No