en Effect of electrical lesion of amygdala basolateral-lateral nuclei on the piriform cortex kindled seizures in rats Experimental research article Experimental research article <p>P Shahabi1, SJ Mirnajafi-Zadeh1, Y Fathollahi1, N Hosseinmardi1, ME Rezvani1, A Eslamifar2 and Z Deljou2</p><p><b><i><font face="TimesNewRomanPS-BoldItalicMT" size="2"></font><font face="TimesNewRomanPS-BoldMT"><p align="left"><font size="2">Abstract:</font></p></font><font face="TimesNewRomanPSMT"><p align="left"><font size="2">Amygdala and piriform cortex have critical role in temporal lobe seizures and determination of their precise role</font></p><p align="left"><font size="2">in these kinds of seizures is very important. In this study the effect of electrical lesion of amygdale basolaterallateral</font></p><p align="left"><font size="2">nuclei on the piriform cortex kindled seizures was investigated.</font></p><p align="left"><font size="2">Rats were kindled by daily electrical stimulation of piriform cortex. In the first experiment fully kindled animals</font></p><p align="left"><font size="2">received intra-amygdala 2% lidocaine (for reversal neuronal inhibition) bilaterally. Five min later, animals were</font></p><p align="left"><font size="2">stimulated and seizure parameters were measured. In second experiment, the amygdala of kindled animals was</font></p><p align="left"><font size="2">lesioned by electrical DC current bilaterally and animals were stimulated 24 h later. Daily stimulations of these</font></p><p align="left"><font size="2">animals continued for 5 days after lesion.</font></p><p align="left"><font size="2">Intra-amygdala lidocaine reduced the kindled seizures severity. There were significant increase in stage 4 latency</font></p><p align="left"><font size="2">and decrease in stage 5 duration. Amygdala lesion reduced the seizures severity more dramatically and all seizure</font></p><p align="left"><font size="2">parameters with except to seizure stage were reduced significantly. The significant reduction in seizure parameters</font></p><p align="left"><font size="2">was observed for 4 days after amygdala lesion.</font></p><p align="left"><font size="2">The basolateral-lateral amygdala neuronal activity has a critical role in propagation of epileptic seizures from</font></p><p align="left"><font size="2">piriform cortex. Elimination of this activity decreases the severity of piriform cortex kindled seizures. However,</font></p><p align="left"><font size="2">this decrease is temporally and several days later (probably because of other brain regions activation) the seizure</font></p><p align="left"><font size="2">parameters return to their control values.</font></p></font><b><font face="TimesNewRomanPS-BoldMT"><p align="left"><font size="2">Keywords: </font></p></font><font face="TimesNewRomanPSMT" size="3"><font size="2">Seizure, Piriform cortex, Amygdala, Electrical lesion, lidocaine.</font></font></b></i></b> </p><p align="left">1<font size="2">. Dept. Physiology, School of Medical Sciences, Tarbiat Modares University, Tehran, Iran.</font></p><p align="left"><font size="2">2. Pasteur Institute, Tehran, Iran.</font></p> 99 105 http://ppj.phypha.ir/browse.php?a_code=A-10-51-1&slc_lang=en&sid=1