en Comparison of effects of two anesthetic drugs, urethan and ketamine-rompane on basal, histamine-, carbachol-, and pentagastrin-induced gastric acid secretion in male rats Experimental research article Experimental research article <b><font face="TimesNewRomanPS-BoldMT" size="2"><p align="left">A Ghanbari and A Eliassi</p></font><i><font face="TimesNewRomanPS-BoldItalicMT" size="2"><p align="left">Dept. Physiology and Neuroscience Research Center, Shaheed Beheshti University of Medical Sciences, Tehran, Iran.</p></font><font face="TimesNewRomanPS-BoldMT" size="3"><p align="left">Abstract:</p></font><font face="TimesNewRomanPSMT" size="3"><p align="left">Urethan inhibits basal and histamine-stimulated gastric acid secretion (GAS). Also, ether induces similar effect on the</p><p align="left">basal and stimulated acid output. Anesthetized animals are often used in studies of regulatory mechanisms of GAS.</p><p align="left">Therefore, considering the effect of anesthetic drugs on the acid secretion is very important. The aim of this study is to</p><p align="left">compare the effects of anesthetic drugs, ketamine-rompane and urethan, on basal and stimulated gastric acid secretion.</p><p align="left">For all gastric sampling, animals were anesthetized and a polyethylene tube was introduced into the stomach</p><p align="left">through esophagus and a cannula was inserted into the pyloroduodenal junction and passed up into the stomach</p><p align="left">for saline injection and aspiration of gastric secretion, respectively. Our experiments revealed that basal acid</p><p align="left">output significantly reduced in rats given urethan compared to ketamine-rompane treated rats (P < 0.001). Also,</p><p align="left">intravenous infusion of histamine (0.5 mg/100 g/hr) and pentagastrin (2 microgram/100 g/hr) induced marked</p><p align="left">increase in acid secretion with a peak response that was started from min 30 and continued up to the end of</p><p align="left">experiments (min 90). Intravenous infusion of carbachol (1 microgram/100 g/ hr) induces marked increase in acid</p><p align="left">secretion with a peak response that was started from min 10 and continued up to min 90. In all groups, urethan</p><p align="left">compared with ketamine-rompane significantly reduced the stimulated gastric acid secretion.</p></font><b><font face="TimesNewRomanPS-BoldMT" size="3"><p align="left">Keywords: </p><p align="left">Pentagasterine.</p></font><font face="TimesNewRomanPSMT" size="3">Urethan, Ketamine, Anesthetized rat(s), Stimulated gastric acid secretion, Carbachol, Histamine,</font></b></i></b> 121 126 http://ppj.phypha.ir/browse.php?a_code=A-10-68-1&slc_lang=en&sid=1