Physiology and Pharmacology

en Comparison of the effects of Vitamin E and Ibuprofen on the severity of primary dysmenorrheal. Experimental research article Experimental research article M Farahmand1, S Zahedi-Asl1, Z Abbaspour2 and A Rasekh31. Endocrinology and Metabolism Research Center, Shaheed Beheshti Univ. Med. Sci., Tehran, Iran.2. School of Nursing, Ahwaz Univ. Med. Sci., Ahwaz, Iran.3. Dept. Statistic, Shaheed Chamran Univ. Ahwaz, Iran.Abstract:Primary dysmenorrhea has relatively high incidence which can influence the well being and activities of the sufferers.An clinical trial cross-over study was designed to compare the effectiveness of Vitamin E and Ibuprofen on onreducing the severity of dysmenorrhea symptoms. Seventy five female students, aged between 18-22 (X+SE) whowere suffering from primary dysmenorrhea were recruited. After having written consent they were divided in twogroups of 40 and 35 and were received 500 units of Vit E ( 2 tablets of 400 and 100 units) and 1200 mg Ibuprofen(400 mg TDS) per day respectively. Treatment with Vit. E was started 2 days before the beginning of menstruationand continued until the first day of bleeding (3 days in total) and Ibuprofen was administered only during the first24 hours of mence (only one day. Monitoring was carried out fore 2 consecutive cycles in both groups, crossoverwas carried out and observation was continued for another 2 cycles.The result of this study indicate that both vitamin E and Ibuprofen could reduce the severity of the pain similarly ,nevertheless but Vit E consumption, complications such as digestive disorders and fatigue were significantly less comparedto Ibuprofen. It appears that Ibuprofen could be replaced by Vit. E in reducing complications of dysmenorrhea.Keywords: Pain, Primary dysmenorrhea, Ibuprofen, Vitamin E. 139 142 http://ppj.phypha.ir/browse.php?a_code=A-10-72-1&slc_lang=en&sid=1