Physiology and Pharmacology
Physiol Pharmacol
Medical Sciences
http://ppj.phypha.ir
32
journal32
24765236
24765244
10.22034
(previous ISSN: 17350581)
en
jalali
1387
10
1
gregorian
2009
1
1
12
4
online
1
fulltext
en
Association between tobacco smoke and serum nitric oxide metabolites concentration
Cardiovascular Physiology/Pharmacology
Cardiovascular Physiology/Pharmacology
Experimental research article
Experimental research article
Introduction: Cigarette smoking affects nitric oxide production. The aim of this study was to determine
associations between tobacco smoke and serum nitric oxide metabolites (NOx) concentration.
Methods: Serum NOx concentration was measured by the Griess method in 230 nonsmokers, 238 active, 196
passive and 29 waterpipe smokers. Subjects were selected from participants of Tehran Lipid and Glucose Study and
blood samples were taken 12-14 h after overnight fasting. Mean NOx values were compared between groups by
analysis of variance and p values less than 0.05 were considered significant.
Results: Serum NOx concentration was significantly higher in smokers (28.2±1.0 μmol/l) compared to passive
(25.8±1.0 μmol/l) and nonsmokers (25.3±1.0 μmol/l) (p<0.05), while no significant difference was found in the level of
NOx between passive and waterpipe smokers (29.0 ±1.1 μmol/l) compared to nonsmokers.
Conclusion: Serum NOx concentration is increased in active smokers, which may be involved in the development
of vascular diseases.
Nitric oxide, Waterpipe, Cigarette smoke, Human.
336
341
http://ppj.phypha.ir/browse.php?a_code=A-10-72-4&slc_lang=en&sid=1
Asghar
Ghasemi
Ghaseni@endocrine.ac.ir
320031947532846004999
320031947532846004999
No
Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University (M.C) Tehran,Iran
Leila
Siadmoradi
siadmoradi@yahoo.com
320031947532846005000
320031947532846005000
No
Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University (M.C) Tehran,Iran
Amir Abbas
Momenan
Momenan@endocrine.ac.ir
320031947532846005001
320031947532846005001
No
Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University (M.C) Tehran,Iran
Saleh
Zahedi Asl
Zahedi@endocrine.ac.ir
320031947532846005002
320031947532846005002
Yes
Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University (M.C) Tehran,Iran