Physiology and Pharmacology
Physiol Pharmacol
Medical Sciences
http://ppj.phypha.ir
32
journal32
24765236
24765244
10.61186/phypha
(previous ISSN: 17350581)
en
jalali
1390
5
1
gregorian
2011
8
1
15
2
online
1
fulltext
en
Coexpression of gonadotropin inhibitory hormone with Agouti-related peptide in the neurons of arcuate nucleus of ewe hypothalamus
Nervous system (others)
Others
Experimental research article
Experimental research article
Introduction: Gonadotropin inhibitory hormone (GnIH) and Agouti-related peptide (AgRP) are orexigenic peptides
expressed in the arcuate nucleus (Arc) of the hypothalamus in the ewe. In addition, effects of GnIH and AgRP on the
regulation of gonadotropin releasing hormone secretion have been shown in some mammals. The objective of the
present study was to investigate the coexpression of GnIH and AgRP in Arc of the ewe hypothalamus.
Methods: Nine ewes were divided into follicular, luteal, and ovariectomised groups (n = 3 each group) and the
number of neurons that express GnIH and AgRP and the percentage of coexpression of these two peptides in the Arc of
each group was estimated by using immunohistochemistry.
Results: In different ovarian conditions of ewes, 19 to 32 percent of GnIH and AgRP neurons were coexpressed in
the Arc of the hypothalamus.
Conclusion: Results of the present study showed a possible cooperative role of AgRP and GnIH in the Arc of the
hypothalamus in regulation of ovarian function in ewe.
Gonadotropin inhibitory hormone, Agouti-related peptide, Arcuate nucleus, Ewe
201
209
http://ppj.phypha.ir/browse.php?a_code=A-10-393-3&slc_lang=en&sid=1
Mohammad Reza
Jafarzadeh Shirazi
mrjaafarzadeh@yahoo.com
320031947532846009128
320031947532846009128
No
Department of Animal Sciences, School of Agriculture, Shiraz University, Shiraz, Iran
Amin
Tamadon
tamadon@shirazu.ac.ir
320031947532846009129
320031947532846009129
No
Stem Cell and Transgenic Technology Research Center, Shiraz University of Medical Sciences & Department of Animal Health Management, School of Veterinary Medicine, Shiraz University, Shiraz, Iran
Mohammad Reza
Namavar
namavarm@sums.ac.ir
320031947532846009130
320031947532846009130
Yes
Department of Anatomical Sciences, School of Medicine & Histomorphometry and Stereology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran