Physiology and Pharmacology
Physiol Pharmacol
Medical Sciences
http://ppj.phypha.ir
32
journal32
24765236
24765244
10.22034
(previous ISSN: 17350581)
en
jalali
1390
7
1
gregorian
2011
10
1
15
3
online
1
fulltext
en
Effect of prolonged exposure to low-frequency electromagnetic fields on the interaction of nitrergic and cholinergic systems in the isolated rat trachea
Respiratory Physiology/Pharmacology
Respiratory Physiology/Pharmacology
Experimental research article
Experimental research article
Introduction: Nitric Oxide is an important endogenous compound that acts as bronchodilator in trachea.
Electromagnetic fields (EMF) affect nitric oxide level in different tissues. The interaction of nitrergic and cholinergic
systems in airways has been reported. Therefore, the present study was performed to evaluate the interaction of
cholinergic and nitrergic systems in the trachea of rats that have been exposed to EMF.
Methods: Adult male rats were divided into 3 groups: experimental group was exposed to 1 mT (militesla) EMF for
135 days, sham group was kept in the same condition but in off solenoid and control group was kept in normal
condition. After 135 days, the mechanical response of transverse rings of isolated trachea to acetylcholine in the
absence and presence of L-NAME, an inhibitor of nitric oxide synthesis, were recorded using PowerLab-AD system.
Results: The results showed a significant increase in cholinergic contractions of trachea in the presence of L-NAME
in control and sham groups (P< 0.05). However this enhancement of contraction was not detected in EMF exposed
group.
Conclusion: It can be concluded that nitric oxide has a modulatory effect on the airway cholinergic contraction,
however this modulation is inhibited by prolonged exposure to EMF.
electromagnetic field, trachea, nitrergic system
385
394
http://ppj.phypha.ir/browse.php?a_code=A-10-490-1&slc_lang=en&sid=1
Tahereh sadat
Javadifar
tjavadifar@yahoo.com
3200319475328460010065
3200319475328460010065
No
SHIRAZ UNIVERSITY
Aminollah
Bahaoddini
bahaodini@shirazu.ac.ir
3200319475328460010066
3200319475328460010066
Yes
SHIRAZ UNIVERSITY
Mohammad Ali
Ketabi
maketabi21@yahoo.com
3200319475328460010067
3200319475328460010067
No
Shahid beheshti of medical science
Firozeh
Gholampour
3200319475328460010068
3200319475328460010068
No
SHIRAZ UNIVERSITY
Hosein
Mirkhanni
3200319475328460010069
3200319475328460010069
No
shiraz university of medical sciences