Physiology and Pharmacology
Physiol Pharmacol
Medical Sciences
http://ppj.phypha.ir
32
journal32
24765236
24765244
10.61882/phypha
(previous ISSN: 17350581)
en
jalali
1390
5
1
gregorian
2011
8
1
15
2
online
1
fulltext
en
Effect of lactation on the expression of gonadotropin-inhibitory hormone in dorsomedial and paraventricular nuclei of the rat hypothalamus
Endocrine Physiology/Pharmacology
Endocrine Physiology/Pharmacology
Experimental research article
Experimental research article
Introduction: Gonadotropin inhibitory hormone (GnIH) is believed to be an inhibitor of gonadotropin releasing
hormone (GnRH) secretion. The role of GnIH in lactational inhibition of gonadotropin secretion is not well known
therefore, the aim of the present study was to evaluate the effect of lactation on expression of GnIH in these nuclei of
lactating and non-lactating rats.
Methods: Ten postpartum rats of the Sprague-Dawley strain were randomly allotted into two groups. The number
of pups was adjusted to five pups per suckling female, while the control non-lactating rats were separated from their
pups immediately upon parturition. The lactating rats were allowed to suckle their pups for eight days. The number of
GnIH neurons in the dorsomedial (DMH) and paraventricular (PVN) nuclei was estimated using an
immunohistochemical method.
Results: The number of GnIH neurons in DMH (P=0.005) and PVN (P=0.001) of lactating rats were significantly
higher than those of the non-lactating rats. Moreover, fibers of GnIH neurons were observed in anteroventral
periventricular nucleus (AVPV) in lactating rats.
Conclusion: Lactation increased GnIH expression in DMH and PVN of the lactating rats, and thus may have a role
in inhibiting GnRH and subsequently LH secretion during the lactation period.
Gonadotropin inhibitory hormone, Lactation, Dorsomedial nucleus, Paraventricular nucleus, Rat
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http://ppj.phypha.ir/browse.php?a_code=A-10-393-4&slc_lang=en&sid=1
Hamed
Adavi
hamedadavi@gmail.com
320031947532846009148
320031947532846009148
No
Graduate Student, Department of Animal Sciences
Mohammad Reza
Jafarzadeh Shirazi
mrjaafarzadeh@yahoo.com
320031947532846009149
320031947532846009149
No
Department of Animal Sciences
Mohammad Javad
Zamiri
zamiri@shirazu.ac.ir
320031947532846009150
320031947532846009150
No
Department of Animal Sciences
Mohammad Reza
Namavar
namavarm@sums.ac.ir
320031947532846009151
320031947532846009151
No
Histomorphometry and Stereology Research Center
Nader
Tanideh
nadertanideh@yahoo.com
320031947532846009152
320031947532846009152
No
Stem Cell and Transgenic Technology Research Center
Amin
Tamadon
tamadon@shirazu.ac.ir
320031947532846009153
320031947532846009153
Yes
Division of Animal Health Management