Physiology and Pharmacology
Physiol Pharmacol
Medical Sciences
http://ppj.phypha.ir
32
journal32
24765236
24765244
10.61186/phypha
(previous ISSN: 17350581)
en
jalali
1390
10
1
gregorian
2012
1
1
15
4
online
1
fulltext
en
Effects of endogenous production and exogenous administration of H2S on gastric acid secretion in rats
Gastrointestinal Physiology/Pharmacology
Gastrointestinal Physiology/Pharmacology
Experimental research article
Experimental research article
Introduction: Recently, hydrogen sulfide has been introduced as the third gas that acts as a transmitter. It has many
physiological and pharmacological roles in the human body. The aim of the present study was to investigate the effect
of exogenously administered and endogenously produced H2S on the basal and distention-induced gastric acid secretion
in rats.
Methods: Forty-nine male Wistar rats (150-200 g) were randomly assigned into 7 groups (7 rats per group). To
evaluate the effect of H2S on the basal acid secretion, three groups of animals received an IV bolus of NaHS, a H2S
donor, at the doses of 20, 40 or 80 μg/Kg. The effects of IV NaHS 20, 40 or 80 μg/Kg were also investigated on
distention-induced gastric acid secretion in other three groups. In order to evaluate the effect of endogenously produced
H2S on distention-induced gastric acid secretion, one group of animals received IV propargylglycine (PAG), a
cystathionine-γ-lyase inhibitor, 100 mg/kg.
Results: NaHS decreased the basal and distention-induced gastric acid secretion in a dose-dependent manner
(P<0.01). PAG increased the gastric output in response to distention compared to the control group (P<0.001).
Conclusion: Our results showed that both exogenous administration and endogenous production of H2S decrease
the gastric acid output. Also, the findings of the present study suggest that endogenously produced H2S has a
modulatory effect on stimulated gastric acid output similar to nitric oxide (NO).
gastric acid output, NaHS, PAG, rat
499
506
http://ppj.phypha.ir/browse.php?a_code=A-10-35-2&slc_lang=en&sid=1
seyyed Ali
Mard
alimard77@gmail.com
320031947532846009917
320031947532846009917
Yes
Physiology Research Center and Dept. Physiology, the school of Medicine, Ahvaz Jundi Shapur University of Medical Sciences, Ahvaz, Iran
Maryam
Maleki
maryammaleki777@yahoo.com
320031947532846009918
320031947532846009918
No
Physiology Research Center and Dept. Physiology, the school of Medicine, Ahvaz Jundi Shapur University of Medical Sciences, Ahvaz, Iran
Mohammad Kazem
Gharib Naseri
gharibnaseri_m@yahoo.com
320031947532846009919
320031947532846009919
No
Physiology Research Center and Dept. Physiology, the school of Medicine, Ahvaz Jundi Shapur University of Medical Sciences, Ahvaz, Iran
Alihosein
Saberi
320031947532846009920
320031947532846009920
No