Physiology and Pharmacology
Physiol Pharmacol
Medical Sciences
http://ppj.phypha.ir
32
journal32
24765236
24765244
10.22034
(previous ISSN: 17350581)
en
jalali
1390
10
1
gregorian
2012
1
1
15
4
online
1
fulltext
en
Acute direct effects of cyclosporine on extracellular field potential of isolated rabbit AV node during experimental atrial fibrillation
Pharmacokinetics/Dynamics
Pharmacokinetics/Dynamics
Experimental research article
Experimental research article
Introduction: Previous studies have indicated a relationship between MPTP pore and AV nodal rate-dependent
properties. The aim of present study was to determine acute direct effects of cyclosporine on extracellular field potential
of isolated rabbit AV node during experimental atrial fibrillation.
Methods: In one group of male New Zealand rabbits (1.5-2.5 kg) cumulative concentrations of cyclosporine (0.5 –
10 m) were applied on isolated perfused atrio-nodal preparation (n=7). Extracellular field potential recording was
sampled during specific stimulation protocols (recovery, zone of concealment and atrial fibrillation) in the presence of
drug on electrophysiological properties of AV-node.
Results: Cyclosporine significantly decreased the ventricular rate (HH mean) from 231.8 ± 5.7 to 277.4 ± 14.6 msec
and functional refractory period during AF (AF FRP) from 138.3 ± 7.5 to 161.2 ± 10.31 msec in control and treated
groups, respectively. Effective refractory period during AF (AF ERP) was significantly decreased by cyclosporine 10
mM compared to control group (p<0.05).
Conclusion: Cyclosporine-evoked slowing ventricular heart rate during AF was induced by increasing functional
refractoy period and ZOC. A possible mechanism can be through blocking of MPT pores.
Atrio-ventricular node, Cyclosporine, mitochondrial permeability transitional pores, atrial fibrillation
507
516
http://ppj.phypha.ir/browse.php?a_code=A-10-245-12&slc_lang=en&sid=1
Vahid
Khori
vaph99@yahoo.com
3200319475328460010483
3200319475328460010483
No
Golestan Cardiovascular Research Center
Samaneh
Naeimipour
shariat@yahoo.com
3200319475328460010484
3200319475328460010484
No
Alimohammad
Alizadeh
3200319475328460010485
3200319475328460010485
No
Cancer research center, tehran university of medical sciences, tehran,iran.
Ali
Haeri Rouhani
3200319475328460010486
3200319475328460010486
No
Mona
Pourabouk
abook_8181@yahoo.com
3200319475328460010487
3200319475328460010487
No
Golestan Cardiovascular Research Center
Fakhri
Badaghabadi
nazari_2005@yahoo.com
3200319475328460010488
3200319475328460010488
No
Golestan Cardiovascular Research Center
Maryam
Rajaei
3200319475328460010489
3200319475328460010489
No
Golestan Cardiovascular Research Center
Sepideh
Shariatnezhad
3200319475328460010490
3200319475328460010490
No
Golestan Cardiovascular Research Center
Hamidreza
Moheimani
3200319475328460010491
3200319475328460010491
No
Golestan Cardiovascular Research Center
Saeed
Saleki
3200319475328460010492
3200319475328460010492
No
Golestan Cardiovascular Research Center
Mohammad Ali
Zeyghami
3200319475328460010493
3200319475328460010493
No
Mohsen
Nayebpour
vaph99@yahoo.com
3200319475328460010494
3200319475328460010494
Yes
tehran university of medical sciences, tehran,iran