en jalali 1403 12 1 gregorian 2025 3 1 29 1 online 1 fulltext

en no abstract Uremic pruritus,Hemodialysis,Patients 1 2 http://ppj.phypha.ir/browse.php?a_code=A-10-2345-1&slc_lang=en&sid=1 2024/03/5 1402/12/15 2024/06/15 1403/3/26 Nader Aghakhani Food and Beverages Safety Research Center, Urmia University of Medical Sciences, Urmia, Iran naderaghakhani2000@gmail.com 00319475328460037064 00319475328460037064 No Vian Afan Naqshbandi Department of Nursing, College of Nursing, Hawler Medical University, Erbil-Iraq n.vian@yahoo.com 00319475328460037065 00319475328460037065 No Roya Naderi Department of Physiology, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran r_naderi_s@yahoo.com 00319475328460037066 00319475328460037066 Yes

en Alzheimer’s disease (AD) is a progressive neurodegenerative disorder with a high prevalence worldwide. It is associated with annoying and debilitating cognitive and memory deficits. For many years, various herbs have been consumed to boost memory and other dementia-related complications. Acetylcholinesterase (AChE) inhibitory, antioxidant properties, and neuroprotective effects of medicinal plants have broadened their application in the treatment of neurodegenerative diseases. Among them, compounds of T. grandiflora, including the methanol extract, depicted antioxidant and hydroxy radical scavenging properties. Likewise, Zingiber officinale and resveratrol have been suggested to demonstrate a neuroprotective effect. Besides, there is a long list of herbal medicines with AChE inhibitory action listed as follows: T. grandiflora, A. paniculata, S. officinalis, G. nivalis, A. calamus, N. jatamansi, M. Allemão, C. sativum, C. tubulosa, and silymarin a flavonoid derived from Silybum marianum (L.) Gaertn. Moreover, Ginkgo biloba L., Curcuma longa L, and natural bioactive compounds including silymarin, and resveratrol, can inhibit the formation and progression of amyloid-beta (Aβ), increase synaptic accumulation of acetylcholine, modulate the degree of tau protein phosphorylation, provide oxidative stress protection, and attenuate neuroinflammation. Herbal compounds involved in AD signaling pathways could affect various pathological processes related to AD and may be beneficial for AD treatment. In this review, the impact of medicinal herbs in alleviating AD symptoms is discussed, for which three databases including PubMed, Web of Science, and Scopus were selected with the keywords of Alzheimer’s disease, medical herbs, signaling pathway, and plants Alzheimer Disease, Antioxidants, Cognition, Oxidative Stress, Herb-Drug Interactions 3 24 http://ppj.phypha.ir/browse.php?a_code=A-10-2256-1&slc_lang=en&sid=1 2024/03/52023/11/22 1402/9/1 2024/06/152024/06/18 1403/3/29 Shahram Darabi Department of Anatomical Sciences, School of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran. darabii_sh1@ymail.com 00319475328460037028 0000000294056640 No Armin Ariaei Student Research Committee, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran armin.ari12@ymail.com 00319475328460037029 0000000333839710 No Enam Alhagh Charkhat Gorgich Department of Anatomy, School of Medicine, Iranshahr University of Medical Sciences, Iranshahr, Iran. enam.gorgich@yahoo.com 00319475328460037030 00319475328460037030 No Shohreh Rezaei Kurdistan University of Medical Sciences, Sanandaj, Iran rezaeii_sher@yahoo.com 00319475328460037031 0000000236932841 No Masume Behruzi Department of Anatomy, School of Medicine, Iran University of Medical Sciences, Tehran, Iran behrroozii.Ma@ymail.com 00319475328460037032 0009000435542755 No Zahra Abasian Department of Clinical Biochemistry, Faculty of Medicine, Iran University of Medical Science, Tehran abassie.zzahrr@yahoo.com 00319475328460037033 0009000436464437 No Auob Rustamzadeh Department of Anatomical Sciences, School of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran a.rustamzadeh@qums.ac.ir 00319475328460037034 00319475328460037034 Yes

en The significance of height in boosting self-confidence has prompted some families to seek medical interventions to enhance their children’s stature. One such intervention is hormone therapy using recombinant human growth hormone (rhGH), which has been employed in clinics since 1985, primarily for treating growth hormone deficiency (GHD). Over time, rhGH therapy has been utilized for various conditions where childhood short stature is not solely a result of inadequate growth hormone secretion, such as small for gestational age (SGA) or idiopathic short stature (ISS). In addition to its effects on the skeletal system, growth hormone (GH) also plays a vital role in regulating cardiovascular function. There is growing evidence suggesting a correlation between abnormal GH levels—both elevated and deficient—and increased cardiovascular morbidity and mortality among patients with GH disorder. Notably, cardiovascular complications are not limited to pathological GH levels; even slight increases within the normal range have been linked to increased cardiovascular disease (CVD) events in healthy individuals. These findings raise concerns about the potential long-term cardiovascular effects of rhGH therapy, especially among children without GH disorders. In this comprehensive review, we summarized recent research findings to provide insights into the physiological and pathophysiological effects of GH on the heart. We aimed to elucidate the long-term side effects of GH therapy and identify associated risk factors. Growth hormone,Insulin-Like Growth Factor I,cardiovascular diseases,Hormone Replacement Therapy 25 34 http://ppj.phypha.ir/browse.php?a_code=A-10-1573-2&slc_lang=en&sid=1 2024/03/52023/11/222024/04/3 1403/1/15 2024/06/152024/06/182024/12/31 1403/10/11 Maryam Bagheri Department of Physiology, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran maryam.bagheri@medilam.ac.ir 00319475328460036979 00319475328460036979 No Sajjad Salari Department of Physiology, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran sajjad.salari@gmail.com 00319475328460036980 00319475328460036980 Yes

en Introduction: Glioblastoma (GBM) is the most common malignant brain tumor, and the prognosis of GBM pa-tients is unfavorable. More studies are needed to develop new prognostic tools for predicting GBM patients’ prognosis. This study aims to construct generisk score (GRS) models based on gene expression databases. Methods: Genomic data of GBM were downloaded from the CGGA, TCGA, MYO, and CPTAC. Patients were divided into two groups with overall survival (OS) of more or less than 15 months. Top 31 genes from our previous study and clinical data such as age, gender, and IDH wildtype/mutant were used to develop two GRS models. Cox methods in SPSS v26 were applied in this study. Results: A total of 551 (334 male, mean age 55.5 ± 13.3 years) cases were used. Fourgene (TGFB1, CCL2, CD274, and TNFRSF1A; from the combination of four databases) and eight-gene (EGFR, TGFB1, SPP1, AGT, TNFRSF1A, CDK1, FOXO3, and CEP55; from CGGA) risk scores were developed. Two models could separate OS samples into high and low-risk groups, and AUCs of 0.984 and, 0.998 were achieved that showed excellent discriminating power at the training set (all: p < 0.0001). For the 8-GRS model, the OS of cases in the high-risk group was poorer than that in the low-risk group when used on another’s datasets at the validation set, however, it was not significant. Conclusion: Four- and eight-gene prognostic signatures were identified and constructed to predict OS in GBM patients. This study may provide innovative insights into the treatment of GBM. Supplementary File  GBM, Gene expression, Prognostic model, Gene risk score 35 43 http://ppj.phypha.ir/browse.php?a_code=A-10-2378-1&slc_lang=en&sid=1 2024/03/52023/11/222024/04/32024/05/7 1403/2/18 2024/06/152024/06/182024/12/312024/05/28 1403/3/8 Parisa Azimi Department of neurosurgery, Alborz University of medical sciences, Karaj, Iran Parisa.azimi@gmail.com 00319475328460036981 00319475328460036981 Yes Abolhassan Ahmadiani Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran aahmadiani@yahoo.com 00319475328460036982 00319475328460036982 No

en Introduction: Ulcerative colitis (UC) is an inflammatory bowel disease (IBD), in which the role of pro-inflammatory cytokines and oxidative stress in its underlying pathogenesis has come into focus. Pistacia Atlantica (P. atlantica) is used in traditional Persian medicine for the management of gastrointestinal disorders. Hence, the present study aimed to investigate the protective effects of hydroalcoholic extract of P. atlantica leaves on acetic acid-induced UC in a rat model. Methods: Male Sprague-Dawley rats were assigned to six groups: normal, colitis by transrectal administration of 4% acetic acid, colitis + sulfasalazine (sulfa, 500 mg/kg/day, intraperitoneally (i.p.)), and colitis + P. atlantica leaves hydroalcoholic extract (at 50, 100, 200 mg/kg/day doses). P. atlantica was administered via oral gavage for 3 consecutive days. After 7 days, colons were resected for macroscopic damage score and histopathological assessment. Furthermore, antioxidant status and inflammatory markers were measured in the serum. Results: Macroscopic and histopathological analysis of the mucosa showed that P. atlantica significantly alleviated colonic damage in a concentration-dependent manner (P<0.001 to P< 0.01). Importantly, in the group treated with P. atlantica, there was a significant reduction in serum nitric oxide (NO) levels (P<0.001), along with restoration of antioxidant systems, as indicated by increased superoxide dismutase (SOD) activity and glutathione (GSH) levels, compared to the colitis rats (P<0.001). Conclusion: These findings indicate the therapeutic potential of P. atlantica leaves in alleviating the severity of colitis in rats by suppressing inflammation and oxidative states in the serum, which could be used as an appropriate drug for the management of UC. Inflammation, Oxidative stress, Pistacia atlantica, Ulcerative colitis, Rat 44 53 http://ppj.phypha.ir/browse.php?a_code=A-10-2259-1&slc_lang=en&sid=1 2024/03/52023/11/222024/04/32024/05/72023/12/3 1402/9/12 2024/06/152024/06/182024/12/312024/05/282024/08/19 1403/5/29 Ramin Nasimi Doost Azgomi Traditional Medicine and Hydrotherapy Research Center, Ardabil University of Medical Sciences, Ardabil, Iran modir7060@yahoo.com 00319475328460036983 00319475328460036983 No Arezoo Moini Jazani Traditional Medicine and Hydrotherapy Research Center, Ardabil University of Medical Sciences, Ardabil, Iran dr.moeeni@yahoo.com 00319475328460036984 00319475328460036984 No Mina Salimi Traditional Medicine and Hydrotherapy Research Center, Ardabil University of Medical Sciences, Ardabil, Iran mina.salimi22@yahoo.com 00319475328460036985 00319475328460036985 No Hosna khazaei Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran hosnakhazaie2018@gmail.com 00319475328460036986 00319475328460036986 No Mohammad hashemnia Department of Pathology, School of Veterinary Medicine, Razi University, Kermanshah, Iran m.hashemnia@razi.ac.ir 00319475328460036987 00319475328460036987 No Sajad Fakhri Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran Pharmacy.sajad@yahoo.com 00319475328460036988 00319475328460036988 No Mohammad Hosein Farzaei Traditional Medicine and Hydrotherapy Research Center, Ardabil University of Medical Sciences, Ardabil, Iran mh.farzaei@gmail.com 00319475328460036989 00319475328460036989 Yes

en Introduction: The cardiovascular effect of the pedunculopontine tegmental nucleus (PPT), a mesencephalic area, has been evaluated. Due to the presence of the GABAB receptor of GABAergic system in the PPT, this study has investigated the possible cardiovascular effect of this receptor in the PPT and has compared it with GABAA. Methods: Rats randomly were divided into control, two doses of 0.5 and 1 nmol of Baclofen (GABAB receptor agonist), 0.5 and 1 nmol, of Phaclofen (GABAB receptor antagonist) and two doses of 0.1 and 0.2 nmol of Bicuculline (BMI, GABAA receptor antagonist) and co-injection of Phaclofen (1nmol)+ Bicuculline (0.2 nmol) groups. After anesthesia, a heparinized polyethylene catheter was placed in the femoral artery and was connected to a pressure transducer cardiovascular response was recorded by a Power lab device. Then the systolic blood pressure (SBP), mean arterial pressure (MAP) and heart rate (HR) were continuously recorded. The injection of drugs into the PPT was done stereotaxically. Cardiovascular changes (Δ,difference between pre and post-injection) induced by drug were calculated and analyzed. Results: Injection of both doses of Baclofen and Phaclofen did not induce significant changes in MAP, SBP, and HR. Injection of both doses of BMI significantly increased ΔMAP, ΔSBP, and ΔHR than control group. Injection of Phaclofen (1nmol) and BMI (0.2 nmol) could increase ΔMAP, ΔSBP, and ΔHR that was non-significant than Phaclofen alone. Conclusion: We found that GABAB receptors of the PPT were not involved in cardiovascular activity and this effect was mainly mediated through GABAA receptors. Mean arterial pressure,Heart rate,Pedunculopontine tegmental nucleus,GABA,Bicuculine 54 62 http://ppj.phypha.ir/browse.php?a_code=A-10-2287-1&slc_lang=en&sid=1 2024/03/52023/11/222024/04/32024/05/72023/12/32023/12/23 1402/10/2 2024/06/152024/06/182024/12/312024/05/282024/08/192024/06/15 1403/3/26 Mohammad Naser Shafei Applied Biomedical Research center, Mashhad University of Medical Science, Mashhad, Iran Division of Neurocognitive Sciences, Psychiatry and Behavioral Sciences Research Center, Mashhad University of Medical Science, Mashhad, Iran ShafeiMN@mums.ac.ir 00319475328460036990 00319475328460036990 No Hossein Pasandi Department of Physiology, Medicine School, Mashhad University of Medical Science, Mashhad, Iran pasandih1@mums.ac.ir 00319475328460036991 00319475328460036991 No Vida Alikhani Department of Physiology, Medicine School, Gonanbad University of Medical Science, Gonabad, Iran alikhaniv4013@mums.ac.ir 00319475328460036992 00319475328460036992 Yes

en Introduction: Oxytocin (OXT) has attracted attention as an effective treatment for anxiety and depression. It also can prevent 3-NP-induced anxiety and depression. However, the effects of OXT can be context-dependent. The objective of this investigation was to explore how prenatal stress (PS) context modulates the effectiveness of OXT in mitigating anxiety-and depression-like behaviors induced by 3-NP, as well as alterations in antioxidant levels. Methods: The dams underwent PS or PS+3NP treatments, and the effects of OXT on the anxiety-like behavior, and depression-like behavior in these treatment groups were evaluated via elevated plus maze and forced swim test respectively. The reduced glutathione (GSH) level was also measured in the striatum, hippocampus, prefrontal cortex, and amygdala. Results: We found that PS per se and 3-NP in the context of PS increased anxiety and depression. These groups also had lower GSH levels in the brain regions examined. OXT pretreatment markedly increased the behavioral changes in the PS group and ameliorated the antioxidant changes. However, OXT pretreatment could not improve 3-NP-induced behavioral and GSH level changes in the context of PS. Conclusion: These findings indicate that OXT improves PS-induced anxiety and depression and the antioxidant level changes, but we found that PS per se thwarts the protective effects of OXT in the 3-NP-induced anxiety and depression Oxytocin, 3-NP, Prenatal stress, Depression, Anxiety 63 73 http://ppj.phypha.ir/browse.php?a_code=A-10-2362-1&slc_lang=en&sid=1 2024/03/52023/11/222024/04/32024/05/72023/12/32023/12/232024/04/18 1403/1/30 2024/06/152024/06/182024/12/312024/05/282024/08/192024/06/152024/08/15 1403/5/25 Fariba Khodagholi Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran khodagholi@sbmu.ac.ir 00319475328460036993 00319475328460036993 No Ali Maleki Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran ali.maleki7424@gmail.com 00319475328460036994 00319475328460036994 No Fereshteh Motamedi Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran motamedi@ams.ac.ir 00319475328460036995 00319475328460036995 No Fatemeh Nasehi NeuroBiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran fatemehnasehi98@gmail.com 00319475328460036996 00319475328460036996 No Arman Zeinaddini Meymand NeuroBiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran armanmeymandzd@gmail.com 00319475328460036997 00319475328460036997 No Forough Foolad Department of Physiology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran forough.foolad@gmail.com 00319475328460036998 00319475328460036998 No Mehdi Moslemi Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran mehdimoslemi83@yahoo.com 00319475328460036999 00319475328460036999 Yes

en Introduction: It is now accepted that scrotal heat stress could adversely affect spermatogenesis. This high thermal condition can cause a reduced male fertility potential. Nowadays, insufficient research exists on the impact of transient scrotal hyperthermia on heat shock proteins 70 and 90 in murine subjects. In the current study, we investigated the effects of scrotal hyperthermia on the expression of heat shock proteins, stereological parameters, and semen quality in mice. Methods: In this examination, a total of 18 healthy adult male NMRI mice were divided equally into two groups: control and scrotal hyperthermia. Scrotal heat stress was induced by placing the lower parts of mice bodies into the water bath for three consecutive days (43°C, 20 min/day). Then, epididymis and testicular samples were collected for evaluation of sperm parameters, stereological study, mRNA, and protein expression of HSP70 and HSP90. Results: Our results revealed that scrotal hyperthermia could strikingly increase the level of mRNA and protein expression of HSP70 and HSP90 in the samples. In addition, stereological parameters and semen quality significantly decreased in transient scrotal hyperthermia-induced mice compared to the control group. Conclusion: Our research indicates that transient hyperthermia on the scrotum can lead to increased expression of HSP70 and HSP90 at both mRNA and protein levels, subsequently affecting male fertility. Hyperthermia, Heat Shock Protein, Testis, Male fertility, Heat stress 74 83 http://ppj.phypha.ir/browse.php?a_code=A-10-2332-1&slc_lang=en&sid=1 2024/03/52023/11/222024/04/32024/05/72023/12/32023/12/232024/04/182024/02/25 1402/12/6 2024/06/152024/06/182024/12/312024/05/282024/08/192024/06/152024/08/152024/06/15 1403/3/26 Azar Afshar Mens Health and Reproductive Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Department of Biology and Anatomical Sciences, School of Medicine, Shahid Beheshti University of Medical Science, Tehran, Iran. azar.afshar8894@gmail.com 00319475328460037000 00319475328460037000 No Fakhroddin Aghajanpour Mens Health and Reproductive Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Department of Biology and Anatomical Sciences, School of Medicine, Shahid Beheshti University of Medical Science, Tehran, Iran. fakhroddin72@gmail.com 00319475328460037001 00319475328460037001 No Reza Soltani Mens Health and Reproductive Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Department of Biology and Anatomical Sciences, School of Medicine, Shahid Beheshti University of Medical Science, Tehran, Iran. rezasoltanikazemii@gmail.com 00319475328460037002 00319475328460037002 No Saeed Vafaei-Nezhad Cellular & Molecular Research Center, Birjand University of Medical Sciences, Birjand, Iran.Department of Anatomical Sciences, School of Medicine, Birjand University of Medical Sciences, Birjand, Iran. vafayisaeed@gmail.com 00319475328460037003 00319475328460037003 No Samira Ezi Department of Anatomy, Faculty of Medicine, Infectious Disease Research Center, Gonabad University of Medical Sciences, Gonabad, Iran. eziysamira@gmail.com 00319475328460037004 00319475328460037004 No Nahid Azad Abnormal Uterine Bleeding Research Center, Semnan University of Medical Sciences, Semnan, Iran nazad1390@gmail.com 00319475328460037005 00319475328460037005 No Abbas Aliaghaei Department of Biology and Anatomical Sciences, School of Medicine, Shahid Beheshti University of Medical Science, Tehran, Iran. aghaei60@gmail.com 00319475328460037006 00319475328460037006 No Mohammad Javad Fridoni Department of Anatomical Sciences, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran. fredoni_javad@yahoo.com 00319475328460037007 00319475328460037007 No Nilofar Tavakoli Department of Biology and Anatomical Sciences, School of Medicine, Shahid Beheshti University of Medical Science, Tehran, Iran. niloofartavakoli.ntr@gmail.com 00319475328460037008 00319475328460037008 No Mohammad-Amin Abdollahifar Mens Health and Reproductive Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Department of Biology and Anatomical Sciences, School of Medicine, Shahid Beheshti University of Medical Science, Tehran, Iran. m_amin58@yahoo.com 00319475328460037009 00319475328460037009 No Mohammad Hossien Heidari Mens Health and Reproductive Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran hosseinheydari1441@gmail.com 00319475328460037010 00319475328460037010 Yes

en Introduction: Metabiotics are promising candidates for peptic ulcer (PU) healing by regulating the expression of pro-inflammatory genes and antioxidant capacity. Methods: We prepared a metabiotic by culturing Lactobacillus acidophilus BF-P-064 and evaluated its cytotoxicity and antioxidant properties by MTT and DPPH (α-diphenyl-β-picrylhydrazyl) methods. To investigate the potential of PU healing, we divided 45 rats into 3 groups and induced PU by administering ethanol. The negative-control group was not treated, while the positive-control and metabiotic groups received treatment with a drug and a metabiotic. On different days, the wound area was determined and the histopathological characteristics were evaluated by H&E staining. The expression of pro-inflammatory cytokines (IL-6, PDGF, VEGF, EGF, TGF-β, and TNF-α) and antioxidant (SOD and GPx) genes was assayed by qRT-PCR method. Results: Our results showed that the metabiotic, at a concentration of 60 mg/mL, had no cytotoxic effects on the CaCo2 cell line, and its antioxidant capacity was 72.49 u/mL. The metabiotic caused faster wound contraction by accelerating the infiltration of phagocytic cells, which intensified the inflammatory phase. By increasing the expression of pro-inflammatory cytokines, as well as enhancing antioxidant properties and the expression of SOD and GPx, the metabiotic prevented the induction of oxidative stress in the tissue. So, the proliferation phase started faster, and the healing process improved. Conclusion: The metabiotic extracted from L. acidophilus BF-P-064 can improve the healing process of PU by increasing the antioxidant capacity, improving the pattern of cell infiltration, and the expression of pro-inflammatory cytokine Metabiotic, Lactobacillus acidophilus, Peptic ulcer, Antioxidant, Pro-inflammatory cytokines 84 95 http://ppj.phypha.ir/browse.php?a_code=A-10-2320-1&slc_lang=en&sid=1 2024/03/52023/11/222024/04/32024/05/72023/12/32023/12/232024/04/182024/02/252024/02/2 1402/11/13 2024/06/152024/06/182024/12/312024/05/282024/08/192024/06/152024/08/152024/06/152024/07/8 1403/4/18 Rika Almasian Department of Microbiology, Faculty of science, Islamic Azad University, Arak branch, Arak, Iran r.almasyan.430@gmail.com 00319475328460037291 00319475328460037291 No Parvaneh Jafari Department of Microbiology, Faculty of science, Islamic Azad University, Arak branch, Arak, Iran pa.jafari@iau.ac.ir 00319475328460037292 00319475328460037292 Yes Ghasem Farjanikish Department of Pathobiology, Faculty of Veterinary Medicine, Lorestan University, Khorram Abad, Iran farjanikish.gh@lu.ac.ir 00319475328460037293 00319475328460037293 No Hassan Noorbazargan Department of Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran h.noorbazargan@sbmu.ac.ir 00319475328460037294 00319475328460037294 No

en Introduction: People with chronic obstructive pulmonary disease (COPD) often experience exacerbations and impaired gas exchange, leading to hypoxemia that may require hospitalization. Pattern analysis of capillary oxygen saturation (SpO2) variability can provide valuable insight into the adaptive capacity of the respiratory control system under this condition. Therefore, this study tested the hypothesis that the adaptability of the respiratory control system is reduced in patients with COPD. Methods: In this study, we utilized entropy and fractal-like correlation properties of SpO2 time series in patients with COPD. We analyzed pulse oximetry data from 13 patients with COPD during hospitalization and discharge time and compared them to 16 age- and sex-matched control subjects. SpO2 variability analysis of a 25-minute time series was performed using sample entropy, multiscale entropy, and detrended fluctuation analysis. Results: Entropy analysis revealed a complex pattern of SpO2 variability in healthy controls and patients with COPD. Both short-term (α1) and long-term fractal-like exponent (α2) were higher in patients with COPD compared to healthy controls. SpO2 entropy and mean were significantly lower in patients with COPD in comparison with controls. There was no statistically significant difference in SpO2 complexity measures between the hospitalization and discharge phases in these patients. Conclusion: The respiratory control system in patients with COPD exhibits less complexity and information processing. These non-invasive analytical methods have the potential for future clinical application to monitor the integrity of respiratory control in individuals suffering from chronic respiratory diseases. oxygen saturation variability, pulse oximetry, entropy, COPD, hypoxia 96 105 http://ppj.phypha.ir/browse.php?a_code=A-10-1265-4&slc_lang=en&sid=1 2024/03/52023/11/222024/04/32024/05/72023/12/32023/12/232024/04/182024/02/252024/02/22023/12/23 1402/10/2 2024/06/152024/06/182024/12/312024/05/282024/08/192024/06/152024/08/152024/06/152024/07/82024/06/15 1403/3/26 Fatemeh Abbasi Feijani Department of Physiology, Faculty of Medicine, Arak University of Medical Sciences, Arak, Iran hanii.abbasi97@gmail.com 00319475328460037015 00319475328460037015 No Saeed Hajihashemi Department of Physiology, Faculty of Medicine, Arak University of Medical Sciences, Arak, Iran s.hajihashemi@gmail.com 00319475328460037016 00319475328460037016 No Abdollatif Moini Department of Internal Medicine, Amiralmomenin Hospital, Arak University of Medical Sciences, Arak, Iran Dr.moini@arakmu.ac.ir 00319475328460037017 00319475328460037017 No Saeed Pazhoohan Department of Physiology, Faculty of Medicine, Arak University of Medical Sciences, Arak, Iran s.pazhoohan@arakmu.ac.ir 00319475328460037018 00319475328460037018 Yes