en
jalali
1394
11
1
gregorian
2016
2
1
20
1
online
1
fulltext
en
Low pH preconditioned amniotic epithelial cells for stem cell therapy of cancer
Amniotic epithelial cells (AECs) possess unique characteristics, which make them a suitable source for cell-based therapeutic strategies. AECs have stem cell properties with low-immunogenicity (due to expressing HLA-G molecule and absence of MHC class I and II antigens) and no ethical problems, as well as availability in sufficient numbers, which can be obtained from a placenta. We have recently shown that the AECs have anti-cancer properties due to inhibition of angiogenesis, induction of apoptosis and cell cycle arrest probably through inhibition of HSP90. Since the viability of AECs must be improved after in vivo administration in acidic microenvironment of tumor, we clarify here that low pH preconditioning of AECs would lead to more survival of implanted cells in tumor site as well as improved functional outcomes.
Amniotic membrane, Epithelial cells, Preconditioning, Cancer, Stem cell therapy.
1
4
http://ppj.phypha.ir/browse.php?a_code=A-12-666-3&slc_lang=en&sid=1
2016/01/16
1394/10/26
2016/03/13
1394/12/23
Hassan
Niknejad
Department of Tissue Engineering and Regenerative Medicine, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
niknejad@sbmu.ac.ir
00319475328460016162
00319475328460016162
Yes
Ghasem
Yazdanpanah
Department of Tissue Engineering and Regenerative Medicine, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
gh.yazdnpnha69@gmail.com
00319475328460016163
00319475328460016163
No
Mona
Kakavand
Nanomedicine and Tissue Engineering Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
mkaka5426954@yahoo.com
00319475328460016164
00319475328460016164
No
Yasaman
Lavaie
Nanomedicine and Tissue Engineering Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Yasaman_jasmine54215@yahoo.com
00319475328460016165
00319475328460016165
No
en
A Review of Animal Models of Alzheimer's Disease: a brief insight to Pharmacologic and genetic models
Alzheimer's disease (AD) is the most common form of neurodegenerative disorders. Memory loss in an alert person and impairment in the function of language, attention, perception, judgment or problem solving can occur in patients with AD. However, there are some medications in order to delay the debilitating aspects of the disease; but unfortunately, scientists could not found approaches to cure this progressive problem. Hence, in order to investigate the exact mechanisms underlying the disease and to discover novel drugs that can slow the progress or alleviate the clinical symptoms of AD, producing a model which can express the most pathophysiologic and behavioral features of the disease is a desire. Nowadays, there are different animal models developed by use of pharmacologic agents and/or genetic manipulations. In this paper, we aimed to describe different animal models of AD, genetic and pharmacologic, that are mostly used by researchers.
Alzheimer\'s disease, Animal model, Pharmacologic model, Genetic model
5
11
http://ppj.phypha.ir/browse.php?a_code=A-11-905-1&slc_lang=en&sid=1
2016/01/162016/02/6
1394/11/17
2016/03/132016/04/11
1395/1/23
Sajjad
Salari
Psychosocial Inury Research Center, Ilam University of Medical Sceinces, Ilam, iran
sajjad.salari@medilam.ac.ir
00319475328460016160
00319475328460016160
No
Maryam
Bagheri
Psychosocial Inury Research Center, Ilam University of Medical Sceinces, Ilam, iran
maryam.bagheri@medilam.ac.ir
00319475328460016161
00319475328460016161
Yes
en
Carbon nanotube-anandamide complex exhibits sustained protective effects in an in vitro model of stroke
Introduction: The therapeutic potential of anandamide (AEA) for the neurological disorders may be negatively affected by its short half-life or poor solubility. The superior properties of carbon nanotubes (CNTs) for controlled drug delivery, prompted us to design AEA-CNTs complex and assess its effect in in vitro model of ischemic stroke.
Methods: In this experimental study, a multi-walled CNTs (MWCNTs)-AEA complex was prepared using amino-functionalized COOH-MWCNTs and characterized by Fourier transform infrared spectroscopy and transmission electron microscopy. PC12 cells in the presence of AEA (0.5, 1, 2 μg/ml), acid- or amine-modified MWCNTs, or MWCNTs-AEA complex (2, 5, 8 μg/ml) were exposed to 1 and 3 h oxygen-glucose deprivation (OGD) followed by 24 h re-oxygenation. In vitro cytotoxicity and oxidative stress were evaluated using three-way ANOVA.
Results: AEA immobilization on the aminated MWCNTs was confirmed. OGD significantly reduced cell viability (P<0.001). After 3 h of OGD induction, COOH-MWCNTs showed higher cytotoxicity than other MWCNTs (P<0.05, P<0.01, P<0.001) and MWCNTs-AEA was more protective than AEA alone (P<0.05, P<0.01). OGD increased malondialdehyde (MDA) and decreased glutathione (GSH) and superoxide dismutase (SOD) (P<0.001). Following 1-h OGD, AEA dose-dependently reduced MDA (P<0.001), and elevated GSH (P<0.05, P<0.01) and SOD (P<0.05, P<0.01), but AEA was ineffective following 3-h OGD (P>0.05). MWCNTs-AEA complex was effective at both time points (MDA and GSH: P<0.01, P<0.001, SOD: P<0.05, P<0.01, P<0.001). This nanostructure was more effective than AEA following longer exposure periods to OGD insult (P<0.05, P<0.01, P<0.001).
Conclusion: Aminated MWCNTs are suitable carriers for AEA and provide longer- lasting effects against OGD insult.
Anandamide, Carbon nanotubes, Ischemic stroke, Oxidative stress
12
23
http://ppj.phypha.ir/browse.php?a_code=A-10-858-3&slc_lang=en&sid=1
2016/01/162016/02/62016/02/3
1394/11/14
2016/03/132016/04/112016/04/6
1395/1/18
Parichehr
Hassanzadeh
Nanotechnology Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
p-hassanzadeh@razi.tums.ac.ir
00319475328460016166
00319475328460016166
Yes
Elham
Arbabi
Research Center for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran
arbabiavalelham@gmail.com
00319475328460016167
00319475328460016167
No
Fatemeh
Atyabi
Nanotechnology Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
atyabifa@tums.ac.ir
00319475328460016168
00319475328460016168
No
Rassoul
Dinarvand
Nanotechnology Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
Dinarvand@tums.ac.ir
00319475328460016169
00319475328460016169
No
en
Antihyperglycemic and antihyperlipidemic effects of hydroalcoholic extract of Melissa officinalis (Lemon Balm) in alloxan-induced diabetic rats
Introduction: Diabetes mellitus is a metabolic disorder of the endocrine system leading to increased blood glucose concentration in the patients. As a basic treatment for managing the blood glucose level, insulin or hypoglycemic medications are used but herbal medicines are more favored. The design of this research project was to study the therapeutic effect of hydroalcoholic extract of Melissa officinalis (HEMO) in diabetic rats.
Methods: Twenty-five Wistar male rats weighing 220±25 grams were distributed semi-randomly into five groups of five each. Group 1 and 2 was respectively the control and diabetic animals. Group 3, 4 and 5 were the diabetic animals treated with HEMO either at 20, 100 or 500 mg/Kg of body weight. To induce diabetic rat models, each animals received a single intraperitoneal injection of alloxan at the dose of 120 mg/Kg. All treatments with HEMO performed daily via gavage for a period of 4 weeks. Then, blood samples were collected from all animals to measure the blood glucose level, cholesterol, triglycerides, LDL and HDL.
Results: The results of this study indicated significant (P<0.05) decreases in blood sugar level, cholesterol, triglycerides and LDL in diabetic rats treated with HEMO. In addition, significant (P<0.05) increase in HDL level was observed in HEMO treated diabetic rats compared with the non-treated ones.
Conclusion: HEMO has significant effects on attenuating the blood sugar level, serum lipids and lipoproteins levels, whereas it improves the HDL level. These effect might be attributed to the antioxidant benefits of flavonoids which are present in HEMO.
Diabetes, Hydroalcoholic Extract, Melissa Officinalis, Alloxan ,Rat
24
30
http://ppj.phypha.ir/browse.php?a_code=A-10-890-1&slc_lang=en&sid=1
2016/01/162016/02/62016/02/32015/10/6
1394/7/14
2016/03/132016/04/112016/04/62016/04/26
1395/2/7
Sedigheh
Khodsooz
Divison of Animal physiology, Department of Biology, Faculty of Sciences, University of Isfahan, Isfahan, Iran
khodsooz_s@yahoo.com
00319475328460016170
00319475328460016170
No
Jamal
Moshtaghian
Divison of Animal physiology, Department of Biology, Faculty of Science, University of Isfahan, Isfahan, Iran
jamalmoshtaghian@gmail.com
00319475328460016171
00319475328460016171
Yes
Mehdi
Eivani
Department of Animal Biology, School of Biology and Center of Excellence in Phylogeny of Living Organisms, College of Science, University of Tehran, Tehran, Iran
mehdi.eivani@gmail.com
00319475328460016172
00319475328460016172
No
en
The protective effects of Curcuma longa extract on oxidative stress markers in the liver induced by Adriamycin in rat
Introduction: The aim of the study was to investigate the effects of Curcuma longa (C. longa) extract on Adriamycin-induced hepatotoxicity in rat.
Methods: Animals were divided in six groups: Control (CO), Adriamycin (ADR), Adriamycin with Vitamin C (ADR+VitC), Vitamin C (Vit C), C. longa with Adriamycin (CL+ADR) and without Adriamycin (CL-ADR). Hepatotoxicity was induced by Adriamycin 5mg/kg and rats were treated with C. longa 1000 mg/kg and Vitamin C 100 mg/kg , per day, orally for 4 weeks.
Results: In the liver tissue of ADR group, Malonyldialdehyde (MDA) level was increased significantly compared to CO group, (p < 0.05). MDA level in the treatment groups, Vit C, CL+ADR and CL-ADR were increased significantly compared to ADR group (p < 0.05, for all three groups), and compared to ADR+VitC group (p < 0.01). Thiol level in ADR, ADR+VitC and CL+ADR groups were decreased compared to CO group (p < 0.001), and also thiol level in CL-ADR and Vit C were increased significantly compared to ADR group (p < 0.01 and p < 0.001 respectively). The activity of catalase in liver tissue in ADR group was lower compared to CO group (p < 0.01), though was increased in CL-ADR, ADR+VitC and Vit C groups in comparison with ADR group (p<0.05, p < 0.01 and p < 0.001, respectively).
Conclusion: The results showed that chronic administration of C. longa hydroalcoholic extract in Adriamycin-induced hepatotoxic rats could decrease the oxidative stress injuries in the liver tissue.
Adriamycin, Curcuma longa, Hepatotoxicity, Oxidative stress, Hydroalcoholic extract, Rat
31
37
http://ppj.phypha.ir/browse.php?a_code=A-10-897-1&slc_lang=en&sid=1
2016/01/162016/02/62016/02/32015/10/62016/01/17
1394/10/27
2016/03/132016/04/112016/04/62016/04/262016/03/2
1394/12/12
Mohammad Reza
Khazdair
Pharmaceutical Research Center and Department of Physiology School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
khazdeirr921@mums.ac.ir
00319475328460016173
00319475328460016173
No
Reza
Mohebbati
Department of Physiology, School of Medicine, Medical University of Mashhad, Mashhad, Iran
mohebbatir931@mums.ac.ir
00319475328460016174
00319475328460016174
Yes
Sareh
Karimi
Department of Physiology, School of Medicine, Medical University of Mashhad, Mashhad, Iran
KarimiS911@mums.ac.ir
00319475328460016175
00319475328460016175
No
Abbasali
Abbasnezhad
Department of Basic Sciences, Faculty of Medicine, Gonabad University of Medical Sciences, Gonabad, Iran
abbasnezhad.abbasali@gmail.com
00319475328460016176
00319475328460016176
No
Milad
Haghshenas
Department of Physiology, School of Medicine, Medical University of Mashhad, Mashhad, Iran
00319475328460016177
00319475328460016177
No
en
Kisspeptin-13 ameliorates memory impairment induced by streptozotocin in male rats via cholinergic system
Introduction: Kisspeptin-13 (KP-13) is a novel endogenous factor, increases synaptic transmission and is involved in several behavioral functions such as anxiety, locomotion, epilepsy and avoidance learning. However, the role of this peptide on cognition has not been well clarified yet. Here we studied the effect of kisspeptin-13 pretreatment on spatial learning and also interaction with cholinergic and adrenergic systems.
Methods: Eighty adult male Wistar rats were divided into 10 groups: saline + saline; saline + STZ; KP-13 + STZ; propranolol + STZ; prazosin + STZ; atropine + STZ; saline + KP-13 + STZ; propranolol + KP-13 + STZ; prazosin + KP-13 + STZ; atropine + KP-13+ STZ. Streptozotocin (STZ) (3mg/Kg) was administrated intracerebroventricularly (i.c.v), kisspeptin-13 was infused (1μg/2μl, i.c.v) 30 minutes before STZ and antagonists were infused (i.p) 30 minutes before kisspeptin-13. Memory performance was measured 14 days after STZ injection using Morris Water Maze (MWM) consisting of 4 blocks and one probe tests.
Results: Pretreatment with kisspeptin-13 ameliorated acquisition (p = 0.001) and retrieval of memory impaired by STZ (P = 0.011). Moreover, we found that injection of atropine, but not propranolol or prazocin was able to reverse the memory enhancement caused by kisspeptin-13 (P = 0.037).
Conclusion: Our findings indicate that facilitatory action of kisspeptin-13 on the spatial learning and memory in STZ-induced Alzheimer’s is mediated, at least in part, through cholinergic systems.
Key words: kispeptin, Spatial memory, Adrenergic system, Cholinergic system, Streptozotocin
38
47
http://ppj.phypha.ir/browse.php?a_code=A-10-369-2&slc_lang=en&sid=1
2016/01/162016/02/62016/02/32015/10/62016/01/172016/02/8
1394/11/19
2016/03/132016/04/112016/04/62016/04/262016/03/22016/03/16
1394/12/26
Maryam
Pourmir
Department of Physiology, Faculty of Medicine, Guilan University of Medical Sciences, Rasht, Iran
pourmir.m@gmail.com
00319475328460016178
00319475328460016178
No
Parvin
Babaei
Department of Physiology, Faculty of Medicine, Guilan University of Medical Sciences, Rasht, Iran
p_babaei@gums.ac.ir
00319475328460016179
00319475328460016179
Yes
Bahram
Soltani Tehrani
Cellular & Molecular Research Center, Guilan University of Medical Sciences, Rasht, Iran
bahram_s_t@yahoo.com
00319475328460016180
00319475328460016180
No
en
Inhibitory effects of oxytocin on the inflammatory parameters and vascular endothelial growth factor (VEGF) in the rat air pouch model of inflammation
Introduction: The aim of the present study was to evaluate the effect of oxytocin on the angiogenesis and inflammatory parameters in air pouch model of inflammation.
Methods: Inflammation was induced by injection of carrageenan into pouches in male Wistar rats. Oxytocin (4.25, 8.5 and 17 μg) was administered intra pouch at the same time as the carrageenan and then for 2 consecutive days. After 72 h, the pouches fluid was collected to determine exudates volume, interleukin 1-beta (IL-1ß) and vascular endothelial growth factor (VEGF) concentrations. Then, the pouches were dissected out, weighed and the hemoglobin concentration was assessed.
Results: All three doses of oxytocin (4.25, 8.5 and 17 μg) significantly decreased volume of exudates (P<0.05, P<0.01 and P<0.001, respectively) while leukocyte accumulation in the pouch fluid was diminished by 8.5 and 17 μg oxytocin. The granulation tissue weight was also markedly reduced in comparison with the control group. A significant reduction in the angiogenesis rate in oxytocin-treated rats by all doses was seen. Interestingly, there was no significant difference between the effect of oxytocin and diclofenac on the inhibition of angiogenesis, VEGF concentration and inflammatory parameters except leukocyte accumulation. In addition, administration of oxytocin (17 μg/pouch) significantly decreased IL-1ß level (47%) compared to the control group (P<0.05).
Conclusion: Oxytocin has an anti-inflammatory effect and inhibits cell influx and exudation to the site of the inflammatory response. The anti-angiogenesis effect of oxytocin may be related to the local inhibition of VEGF levels as similarly shown by diclofenac.
Oxytocin, Air Pouch, Inflammation, VEGF, Angiogenesis
48
56
http://ppj.phypha.ir/browse.php?a_code=A-10-168-4&slc_lang=en&sid=1
2016/01/162016/02/62016/02/32015/10/62016/01/172016/02/82015/09/14
1394/6/23
2016/03/132016/04/112016/04/62016/04/262016/03/22016/03/162016/02/24
1394/12/5
Elliyeh
Ghadrdan
Student Research Committee, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran
00319475328460016181
00319475328460016181
No
Moslem
Najafi
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran Introduction In the recent decades, there have been increasing evidence that a bi-directional communication exists among the immune, endocrine and central nervous systems which plays an important role in maintaining the body's homeostasis (Jiang et al., 1998; Lawrence and Kim, 2000; Maier, 2003; Quan and Banks, 2007; Tian et al., 2012). Oxytocin is a nonapeptide neurotransmitter, hormone produced in hypothalamic nuclei (Szeto et al., 2013). It is mainly involved in uterine contraction during parturition and the milk ejection reflex during lactation (Petersson et al., 2001). Evidence for anti-inflammatory activity of Physiol Pharmacol 20 (2016) 48-56 www.phypha.ir/ppj Abstract Introduction: The aim of the present study was to evaluate the effect of oxytocin on the angiogenesis and inflammatory parameters in air pouch model of inflammation. Methods: Inflammation was induced by injection of carrageenan into pouches in male Wistar rats. Oxytocin (4.25, 8.5 and 17 μg) was administered intra pouch at the same time as the carrageenan and then for 2 consecutive days. After 72 h, the pouches fluid was collected to determine exudates volume, interleukin 1-beta (IL-1ß) and vascular endothelial growth factor (VEGF) concentrations. Then, the pouches were dissected out, weighed and the hemoglobin concentration was assessed. Results: All three doses of oxytocin (4.25, 8.5 and 17 μg) significantly decreased volume of exudates (P<0.05, P<0.01 and P<0.001, respectively) while leukocyte accumulation in the pouch fluid was diminished by 8.5 and 17 μg oxytocin. The granulation tissue weight was also markedly reduced in comparison with the control group. A significant reduction in the angiogenesis rate in oxytocin-treated rats by all doses was seen. Interestingly, there was no significant difference between the effect of oxytocin and diclofenac on the inhibition of angiogenesis, VEGF concentration and inflammatory parameters except leukocyte accumulation. In addition, administration of oxytocin (17 μg/pouch) significantly decreased IL-1ß level (47%) compared to the control group (P<0.05). Conclusion: Oxytocin has an anti-inflammatory effect and inhibits cell influx and exudation to the site of the inflammatory response. The anti-angiogenesis effect of oxytocin may be related to the local inhibition of VEGF levels as similarly shown by diclofenac. Physiology and Pharmacology
00319475328460016182
00319475328460016182
No
Sevda
Mikaily Mirak
Student Research Committee, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran
00319475328460016183
00319475328460016183
No
Tahereh
Eteraf-Oskouei
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran
00319475328460016184
00319475328460016184
Yes
en
Duodenal acidification stimulates gastric H2S release through upregulating mRNA expression of cystathionine gamma lyase
Introduction: It has been reported the alkaline response of pancreas to duodenal acidification is partly mediated through duodenal release of H2S, but till now the effect of duodenal acidification on gastric H2S release has not been investigated. Therefore, the present study designed to evaluate the effects of duodenal acidification on gastric H2S release and level of mRNA expression of cystathionine gamma lyase (CSE).
Methods: Twenty four rats were randomly assigned into 3 groups (8 in each). They were control, pH2-, and pH3-treated groups. Under anesthesia, animals underwent midline laparotomy. Neutral isotonic saline or acidic isotonic solutions (pH=2 or 3) were injected in the duodenum 1 cm just below the pyloric sphincter. Ninety minutes after beginning the experiment, animals were sacrificed, stomachs ligated at lower esophageal sphincter and 2 ml saline infused in the stomach through pylorus and then gastric content was drained for measuring the pH. Two samples of gastric mucosal tissue were quickly snap-frozen and stored in liquid nitrogen for measuring the mucosal H2S concentration using ELISA kit and quantifying the mRNA expression of CSE by quantitative real-time PCR.
Results: Duodenal acidification with acidic solution (pH=2) increased the gastric release of H2S and upregulated mRNA expression of CSE in gastric mucosa. The gastric mucous content was significantly increased in response to duodenal application of acidic solutions with pH2 and 3.
Conclusion: Our findings indicated the stimulatory effect of duodenal acidification on gastric H2S release and mucous content is mediated through upregulation of CSE mRNA expression.
Duodenal acidification, Cystathionine gamma lyase, H2S
57
62
http://ppj.phypha.ir/browse.php?a_code=A-10-35-5&slc_lang=en&sid=1
2016/01/162016/02/62016/02/32015/10/62016/01/172016/02/82015/09/142016/02/13
1394/11/24
2016/03/132016/04/112016/04/62016/04/262016/03/22016/03/162016/02/242016/04/18
1395/1/30
Seyyed Ali
Mard
Physiology Research Center (PRC), Research Center for Infectious Diseases of Digestive System, Department of Physiology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
alimard77@gmail.com
00319475328460016185
00319475328460016185
Yes
Hajar
Godarzinejad
Physiology Research Center (PRC), Research Center for Infectious Diseases of Digestive System, Department of Physiology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
hajar.goudarzi@yahoo.com
00319475328460016186
00319475328460016186
No
Mahin
Dianat
Physiology Research Center (PRC), Department of Physiology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
dianatmah@yahoo.com
00319475328460016187
00319475328460016187
No
en
Isolation and optimization of mice skeletal muscle satellite cells using preplating method and culture media substitution
Introduction: Satellite cells are known as the main regenerative cell type in skeletal muscles. Our study established a modified digestion and preplating method for the isolation of slow or weak adherent cells for the enrichment of satellite cells. Low-survival rate of these primary stem cells prompted us to address whether cell culture medium substitution might change cell viability status.
Methods: Skeletal muscle from 10-day-NMRI mice was gently isolated, dissected and digested by collagenase type I, IV and dispases. The isolated cells were verified by cellular (immunocytochemistry and flow-cytometry) and molecular (real-time PCR) techniques and the results were compared with sub-cultured cells (non-preplated cells) to determine the efficiency of preplating technique as a common isolating procedure of satellite cells. All data were analyzed using SPSS 16 and One Away ANOVA test.
Results: The isolated cells exhibited a close gene expression pattern with satellite cells for self-renewal and fusion phases. The findings revealed that Pax7 as a self-renewal marker was expressed ~ 201.4 times higher than sub-cultured-group. Moreover, the findings obviously indicated that substitution of α-MEM to DMEM cell culture medium improves the survival rates of the cells.
Conclusion: Our results recommend that preplating technique is a useful procedure for the isolation of satellite cells. In addition, it seems that substitution of culture medium paves the way for investigators to seek various therapeutic methods for skeletal muscle-related disorders such as skeletal muscle atrophy (SMA), amyotrophic lateral sclerosis (ALS), sarcopenia, diabetes and aging.
Skeletal Muscle, Satellite cells, Preplate technique, PAX7.
63
73
http://ppj.phypha.ir/browse.php?a_code=A-10-792-2&slc_lang=en&sid=1
2016/01/162016/02/62016/02/32015/10/62016/01/172016/02/82015/09/142016/02/132016/01/6
1394/10/16
2016/03/132016/04/112016/04/62016/04/262016/03/22016/03/162016/02/242016/04/182016/04/13
1395/1/25
Nuredin
Bakhtiari
Department of Biochemistry, Faculty of Basic Sciences, Young Researchers and Elite Club, Sanandaj Branch, Islamic Azad University, Sanandaj, Iran
nuredin.bakhtiary@modares.ac.ir
00319475328460016199
00319475328460016199
Yes