en jalali 1397 9 1 gregorian 2018 12 1 22 4 online 1 fulltext

en Introduction: To improve our understanding of dizziness, its assessment, as well as its management to identify the appropriate treatment in order to reduce the costs and to increase the patients’ quality of life. Methods: A single blind parallel group randomized controlled trial was conducted on 164 participants with dizziness. One group received 25mg/ml promethazine and another received 5mg/ml diazepam. To assess the severity of dizziness, Visual Analog Scale was used prior to and two hours after treatment. Results: Both promethazine and diazepam had significant effects on decreasing the severity of dizziness, i.e. the severity score decreased from 9.31 to 1.81 in promethazine versus 9.33 to 4.50 in diazepam (P<0.001). Conclusion: A single IV dose of promethazine is more effective in reducing vertigo as compared with diazepam. Diazepam, Dizziness, Promethazine, Vertigo, Vestibular 213 218 http://ppj.phypha.ir/browse.php?a_code=A-12-1099-2&slc_lang=en&sid=1 2018/06/14 1397/3/24 2018/11/17 1397/8/26 Seyed Mohsen Fayyazi Department of Emergency Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran mohsen.fayyazi@gmail.com 00319475328460020568 00319475328460020568 No Mehrdad Taghizadeh Department of Emergency Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran Mehrdad.Taghizadeh@gmail.com 00319475328460020569 00319475328460020569 No Zohreh Nabizadeh-Gharghozar Student Research Committee, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran nabizadehfaezeh85@yahoo.com 00319475328460020570 00319475328460020570 No Hamidreza Javadzadeh Department of Emergency Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran Hamidreza.Javadzadeh@gmail.com 00319475328460020571 00319475328460020571 No Sadrollah Mahmudi Department of Emergency Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran Sadrollah.Mahmudi@gmail.com 00319475328460020572 00319475328460020572 No Kamran Heidari Skull Base Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran heidari-k@sbmu.ac.ir 00319475328460020567 00319475328460020567 Yes

en Introduction: Alzheimer’s disease (AD) is a common progressive, neurodegenerative disorder with no preventive or curative therapy until now. Use of natural products as an important source of neuroprotective flavonoids against AD has been considered recently. In this study, the effect of Mespilus germanica leaves (MGL) flavonoids treatment on memory dysfunction and apoptosis in the amyloid beta (Aβ)-treated rat was investigated. Methods: Forty-eight male Wistar rats (220-250g) were divided into 6 groups (n=8): saline, Aβ, treatment (5, 7.5 and 10 mg/kg MGL flavonoids) and positive control group. Step through the passive avoidance test was performed on the 22nd day to examine learning and memory. Immediately afterward, the animals were killed and their brains were removed to measure the levels of cytochrome c in brain homogenate. Results: Our results showed significant improvement in passive avoidance task as flavonoid (10mg/kg) increased step-through latency (P=0.003) and decreased the time spent in dark compartment (P=0.001) significantly. In addition, the levels of cytochrome c which was significantly increased in the Aβ-injected group was reduced remarkably in the flavonoid treatment group (P=0.029). Conclusion: Therefore, MGL flavonoid can improve Aβ1-42 induced memory dysfunction in rats and its effect might be partially due to their role in decreasing apoptosis. Alzheimer’s disease, Amyloid beta, Flavonoids, Passive avoidance, Cytochrome c, Mespilus germanica 219 227 http://ppj.phypha.ir/browse.php?a_code=A-10-656-2&slc_lang=en&sid=1 2018/06/142018/08/13 1397/5/22 2018/11/172018/12/4 1397/9/13 Fatemeh Davoudzadeh Department of Physiology, School of Medicine, Guilan University of Medical Sciences, Rasht, Guilan, Iran 93it.davoudzadeh@gmail.com 00319475328460020573 00319475328460020573 No Parvin Babaei Cellular and Molecular Research Center, Guilan University of Medical Sciences, Rasht, Guilan, Iran p_babaei@yahoo.aom 00319475328460020574 00319475328460020574 No Adele Jafari Neuroscience Research Center, Guilan University of Medical Sciences, Rasht, Guilan, Iran a_jafari@gums.ac.ir 00319475328460020575 00319475328460020575 Yes

en Introduction: The use of standard rodent model, allows for the understanding of neuronal injury physiopathology and helping development of therapeutic strategies. Because of eliminating technical problems, we designed a modified impactor device with ability to induce different degrees according to kilodyne from very mild to very severe of spinal cord injury (SCI) and traumatic brain injury (TBI) models in rat. Methods: For standardization and determining of optimal performance of the device to induce varying injuries, 47 adult male Wistar rats were used, and 8 different forces were applied in spinal cord and brain tissues. Results: The hematoxylin and eosin and 2, 3, 5-triphenyltetrazolium chloride (TTC) results demonstrated that by increasing the level of forces, histological changes in the spinal cord and brain were significantly enhanced. Different injuries had significant effect on the Basso-Beattie-Brenham and elevated body swing test outcomes, and there were significant differences between groups in comparison with control group. Conclusion: Our results showed that the modified device could be valid to produce precise SCI and TBI models, goal to replicate SCI and TBI in humans as much as possible. However, it might be considered that aspects of SCI and TBI models are complicate and more examination is necessary. Spinal cord injury, Traumatic brain injury, Modified impactor. 228 239 http://ppj.phypha.ir/browse.php?a_code=A-10-180-1&slc_lang=en&sid=1 2018/06/142018/08/132018/09/6 1397/6/15 2018/11/172018/12/42018/12/5 1397/9/14 Meysam Ghorbani Neuroscience Research Center, Tabriz University of Medical Sciences, Tabriz, Iran meyssam.neuro@gmail.com 00319475328460020577 00319475328460020577 No Parviz Shahabi Neuroscience Research Center, Tabriz University of Medical Sciences, Tabriz, Iran shahabip@tbzmed.ac.ir 00319475328460020576 00319475328460020576 Yes Abass Ebrahimi-kalan Neuroscience Research Center, Tabriz University of Medical Sciences, Tabriz, Iran abassebra@gmail.com 00319475328460020578 00319475328460020578 No Hamid Soltani-Zangbar Neuroscience Research Center, Tabriz University of Medical Sciences, Tabriz, Iran soltanizangbarhamid@gmail.com 00319475328460020579 00319475328460020579 No Javad Mahmoudi Neuroscience Research Center, Tabriz University of Medical Sciences, Tabriz, Iran mahmoudi2044@yahoo.com 00319475328460020580 00319475328460020580 No Soheila Bani Neuroscience Research Center, Tabriz University of Medical Sciences, Tabriz, Iran banisoheila@yahoo.com 00319475328460020581 00319475328460020581 No Behnaz Sadeghzadeh-Oskouei Faculty of Nursing and Midwifery, Tabriz University of Medical Sciences, Tabriz, Iran Repbio.sbmu@gmail.com 00319475328460020582 00319475328460020582 No Yusef Rafiee-Byraami Neuroscience Research Center, Tabriz University of Medical Sciences, Tabriz, Iran Dr_yusef_rafee@yahoo.com 00319475328460020583 00319475328460020583 No Omid Salimi Neuroscience Research Center, Tabriz University of Medical Sciences, Tabriz, Iran o.salimi1990@gmail.com 00319475328460020584 00319475328460020584 No

en Introduction: Cholinergic neuronal deficiency is one of the main causes of Alzheimer's pathology, which leads to learning and memory impairment. Scopolamine is a muscarinic cholinergic antagonist commonly used to induce Alzheimer's disease (AD). Insulin also regulates learning and memory function. Thus, the aim of this study was to determine the effect of central administration of insulin on passive avoidance learning. Methods: In this experiment, fifty-nine rats were divided into 6 groups: (1) intact, (2) sham, (3) scopolamine-saline, (4) scopolamine-insulin4, (5) scopolamine-insulin8 and (6) scopolamine-insulin16. In addition, scopolamine (70nmol/2μl) was injected into the right lateral ventricle, before the retrieval test of the inhibitory avoidance task. Then the effects of three doses of insulin (4, 8 or 16 mU/2μl) were investigated on the passive avoidance learning in an amnestic model induced by scopolamine. Results: Our results indicate that the retrieval of passive avoidance memory was significantly improved by intracerebroventricular administration of insulin in 4 and 8 mU/2μl doses but not in 16 mU/2μl. Conclusion: These results confirmed that insulin could improve the retrieval phase of passive avoidance memory that was impaired by scopolamine. Insulin, Scopolamine, Learning, Memory, Passive avoidance learning 240 246 http://ppj.phypha.ir/browse.php?a_code=A-10-1140-1&slc_lang=en&sid=1 2018/06/142018/08/132018/09/62018/09/29 1397/7/7 2018/11/172018/12/42018/12/52018/12/9 1397/9/18 Simin Ehsani Department of Physiology and Pharmacology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran sehsani@mazums.ac.ir 00319475328460020585 00319475328460020585 No Esmaeil Akbari Department of Physiology and Pharmacology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran akbari_esmaeil@mazums.ac.ir 00319475328460020586 00319475328460020586 No Motahareh Rouhi Ardeshiri Department of Physiology and Pharmacology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran s.rouhi89@sbmu.ac.ir 00319475328460020587 00319475328460020587 Yes

en Introduction: Ginger has shown anti-nociceptive effects. Here we investigated the possible involvement of GABAA receptors in anti-nociceptive effect of ginger using muscimol (GABAA agonist) and picrotoxin (GABAA antagonist) in rats that received ginger. The pain sensitivity was evaluated by formalin test. Methods: Thirty-five male Sprague-Dawley rats were randomly divided into 7 groups (n=5): sham1 (received distilled water. PO); sham2 (received water + 0.75μl artificial cerebrospinal fluid by intracerebroventricular (ICV) injection; experimental1 (received ginger at 50 mg/kg/day, PO); experimental2 and 3 (received ginger+ 0.75μl of 250 or 500ng/rat muscimol by ICV injection); experimental4 and 5 (received ginger+ 0.75μl of 250 and 500ng/rat picrotoxin by ICV injection). On day 16 and 30min after ICV injections, formalin test was performed on all rats. Results: Ginger significantly reduced pain sensitivity in both phases of formalin test in comparison to sham1 and 2. In early and late phase, both doses of muscimol reduced pain sensitivity as compared to the ginger group. Picrotoxin at 250ng/rat+ ginger reduced pain sensitivity as compared to the group that received ginger, in both the early and the late phases of the formalin test. Picrotoxin at 500ng/rat+ ginger increased pain sensitivity in the early phase and late phase of formalin test as compared to the ginger group. Conclusion: Aqueous- alcoholic extract of ginger has significant analgesic effects in late phase of formalin test and GABAA receptors may be involved in this regard. Ginger, Muscimol, Picrotoxin, Pain sensitivity, Rat. 247 253 http://ppj.phypha.ir/browse.php?a_code=A-10-249-9&slc_lang=en&sid=1 2018/06/142018/08/132018/09/62018/09/292018/08/30 1397/6/8 2018/11/172018/12/42018/12/52018/12/92018/12/8 1397/9/17 Mahnaz Taherianfard Division of Physiology, Department of Basic Sciences, School of Veterinary Medicine, Shiraz University, Shiraz, Iran taherian@shirazu.ac.ir 00319475328460020588 00319475328460020588 Yes Foroohar Farhangdareshuri Division of Physiology, Department of Basic Sciences, School of Veterinary Medicine, Shiraz University, Shiraz, Iran farhang@yahoo.com 00319475328460020590 00319475328460020590 No Tahoora Shomali Division of Pharmacology and Toxicology, Department of Basic Sciences, School of Veterinary Medicine, Shiraz University, Shiraz, Iran shomali@shirazu.ac.ir 00319475328460020589 00319475328460020589 No

en Introduction: Certain types of chronic mental stress impair memory. On the other hand, crocin is introduced in the medical literature as an effective component of saffron with remedial effects on memory impairment. This study investigated the effects of crocin on spatial and cognitive memories, locomotor activity, novel recognition conditions and serum corticosterone levels in rats under chronic isolation stress. Methods: Male rats were randomly allocated to the five groups of control, sham, isolation stress (St.I), St.I-C30 and St.I-C60. The latter two groups were exposed to chronic isolation stress (6h/day) receiving two levels of crocin (30 and 60 mg/kg, respectively) over a period of 21 days. The object location and novel object recognition tests (OLT and NOR) were used to evaluate spatial and cognitive memories, respectively. Results: The OLT results revealed that chronic isolation stress led to significantly decreased locomotor activity in all the stressed groups; the NOR test, however, yielded similar results only in the St.I group. Moreover, isolation stress was found to lead significant declines in spatial and cognitive memories. Finally, crocin administration led to improvements in impaired memory in St.I-C30 and St.I-C60 groups. There were significant enhancements in serum corticosterone levels in the St.I and St.I-C30 groups as compared with the control group. Conclusion: Our findings indicate that spatial and cognitive memory impairments are strongly affected by isolation stress and crocin especially at its high dose of 60 mg/kg, exhibits better protective effects against cognitive memory deficit induced by chronic isolation stress. Crocin, Memory, Isolation stress, Rat 254 268 http://ppj.phypha.ir/browse.php?a_code=A-10-895-4&slc_lang=en&sid=1 2018/06/142018/08/132018/09/62018/09/292018/08/302018/07/8 1397/4/17 2018/11/172018/12/42018/12/52018/12/92018/12/82018/11/12 1397/8/21 Fatemeh Khani Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran fatemeh_khani67@yahoo.com 00319475328460020666 00319475328460020666 No Maryam Radahmadi Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran m_radahmadi@med.mui.ac.ir 00319475328460020667 00319475328460020667 Yes Hojjatallah Alaei Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran alaei@med.mui.ac.ir 00319475328460020668 00319475328460020668 No Elahe Jafari Department of Psychology, Khorasgan Branch, Islamic Azad University, Isfahan, Iran jafari@yahoo.com 00319475328460020669 00319475328460020669 No

en Introduction: Nephropathy is defined as rational loss of renal function related with glomerulosclerosis and declining glomerular filtration rate. Inflammation and oxidative stress play a critical role in nephropathy. Plantago major has antioxidant effects. The aim of present study is the investigation of the effect of Plantago major hydro-alcoholic extract on the oxidative stress and renal function in kidney of rat. Methods: Rats were divided into five groups: control (Co), doxorubicin (DOX), doxorubicin+vitamin E (DOX+Vit E), 600mg/kg Plantago major (PM)+doxorubicin (PM600+DOX), 1200mg/kg Plantago major (PM)+doxorubicin (PM1200+DOX). DOX (5mg/kg, IV), Vit E and PM extract (600 and 1200mg/kg, PO) were administrated for 35 days. Finally, urine, blood samples and renal tissue were collected to measurement of redox markers, functional parameters and renal index percentage. Results: The renal superoxide dismutase (SOD) activity, total thiol and functional parameters significantly reduced and malondialdehyde (MDA) concentration increased in DOX group in comparison with control group. The renal SOD, catalase activities and total thiol content were significantly increased and MDA level decreased in PM treated groups along with DOX group in comparison with DOX group. The functional parameters significantly enhanced in treated groups with PM in comparison with the DOX group. The extract did not relive enhanced % renal index induced by DOX. Conclusion: Hydro-alcoholic extracts of PM, specially at its high dose led to an improvement in DOX-induced renal function and oxidative stress. Doxorubicin, Plantago major, Oxidative stress, Renal function 269 278 http://ppj.phypha.ir/browse.php?a_code=A-10-415-1&slc_lang=en&sid=1 2018/06/142018/08/132018/09/62018/09/292018/08/302018/07/82018/04/7 1397/1/18 2018/11/172018/12/42018/12/52018/12/92018/12/82018/11/122018/10/15 1397/7/23 Nazanin Entezari Heravi Department of Physiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran entezarin931@mums.ac.ir 00319475328460020595 00319475328460020595 No Reza Mohebbati Department of Physiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran mohebbatir931@mums.ac.ir 00319475328460020596 00319475328460020596 No Zohreh Naji Ebrahimi Department of Physiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran najiez921@mums.ac.ir 00319475328460020597 00319475328460020597 No Abolfazl Khajavi Rad Department of Physiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran khajavirada@mums.ac.ir 00319475328460020598 00319475328460020598 Yes Mohammad Naser Shafei Department of Physiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran shafeimn@mums.ac.ir 00319475328460020599 00319475328460020599 No Mohammad Soukhtanloo Department of Clinical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran soukhtanloom@mums.ac.ir 00319475328460020600 00319475328460020600 No Farimah Beheshti Department of Basic Science and Neuroscience Research Center, Torbat Heydariyeh University of Medical Science, Torbat Heydariyeh, Iran beheshtif931@mums.ac.ir 00319475328460020601 00319475328460020601 No Sara Hosseinian Department of Physiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran hosseinians@mums.ac.ir 00319475328460020602 00319475328460020602 No

en Introduction: The aim of the study was to investigate the structural and hemodynamic changes as well as cardiac transcriptional profile of the key regulatory proteins, sirtuins family (SIRT1-7), in adaptive and mal-adaptive phases of left ventricular hypertrophy (LVH). Methods: LVH was induced in male Wistar rats (190±20g) by abdominal aortic banding. The third and sixteenth weeks post-surgery were considered as adaptive and mal-adaptive phases of hypertrophy (H3w and H16w groups, respectively). Blood pressure (BP) was recorded through the carotid artery catheter. Cell area and fibrosis were assessed using haematoxylin/eosin and Masson trichrome staining, respectively. The sirtuins mRNA levels were quantified using quantitative RT–PCR technique. Results: H3w rats had a higher systolic and diastolic BP, cardiomyocytes area and heart to body weight ratio (HW/BW) compared with control (intact animals). Although cell size and HW/BW increased in the H16w group, systolic and diastolic BP did not change significantly in comparison with control. In H3w group, SIRT1/3/6/7 mRNAs levels increased significantly. In H16w group, SIRT1/3/5/6/7 mRNAs levels declined in comparison with H3w group. SIRT2 and SIRT4 mRNA levels did not change significantly among the experimental groups. Conclusion: During progression of cardiac hypertrophy transcriptional profile of sirtuins changes in parallel to structural and hemodynamic parameters. Therefore, it can validate sirtuins as the pharmacological targets for the treatment of pathological LVH. Hypertension, LVH, Adaptive hypertrophy, Mal-adaptive hypertrophy, Sirtuins 1-7 279 291 http://ppj.phypha.ir/browse.php?a_code=A-10-494-6&slc_lang=en&sid=1 2018/06/142018/08/132018/09/62018/09/292018/08/302018/07/82018/04/72018/09/2 1397/6/11 2018/11/172018/12/42018/12/52018/12/92018/12/82018/11/122018/10/152018/12/17 1397/9/26 Mohsen Hosseinnezhad Department of Physiology, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran hossiennezhadmohsen841@gmail.com 00319475328460020605 00319475328460020605 No Mohabbat Jamhiri Department of Physiology, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran mo.bat84@ssu.ac.ir 00319475328460020604 00319475328460020604 No Zeinab Hafizibarjin Department of Physiology, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran hafizi.z1991@ssu.ac.ir 00319475328460020606 00319475328460020606 No Fatemeh Safari Department of Physiology, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran f.safari@ssu.ac.ir 00319475328460020603 00319475328460020603 Yes