en jalali 1 gregorian 1 Accepted Manuscripts online 1 fulltext

en Precision medicine and clinical trials rely heavily on biomarkers, which are crucial tools in clinical research and drug development. Throughout the course of the drug development process, they are crucial in patient enrichment, safety monitoring, and evaluating therapy responses. In addition to illuminating the present worldwide regulatory environment, this article offers a thorough review of biomarker development and classification with a major focus on biomarker validation and qualification. We also explore industry trends and highlight patentable biomarkers that can be used to diagnose a variety of ailments. Additionally, we outline how biomarkers are used in the current regulatory framework and talk about potential obstacles as well as future prospects. This review article provides vital insights into the role that biomarkers play in developing medical and pharmacological breakthroughs as well as their significance and changing landscape. Biomarkers, Development process, Regulatory landscape, Patents, Market trend 0 0 http://ppj.phypha.ir/browse.php?a_code=A-10-2176-1&slc_lang=en&sid=1 2023/08/30 1402/6/8 2024/06/15 1403/3/26 Venkateswara Raju Kalidindi Department of Regulatory Affairs, Shri Vishnu College of Pharmacy, Bhimavaram, West Godavari (Dt.), Andhra Pradesh, India venkateswararaju.k@svcp.edu.in 00319475328460038772 0000000262794710 No Anusha Penamacha SHRI VISHNU COLLEGE OF PHARMACY anuvarma2468@gmail.com 00319475328460038773 0009000803976355 No Lakshmi Prasanthi Nori SHRI VISHNU COLLGE OF PHARMACY lakshmi.n@svcp.edu.in 00319475328460038774 0000000207842484 Yes

en Background: Mucositis is acute oral toxicity induced by radiation or systemic cytotoxic chemotherapy agents in patients with cancer that may lead to discontinuing the treatment or reducing the administered dose. In this study, we aimed to evaluate the preventive effect of oral L-carnitine on chemotherapy-induced mucositis. Methods: This prospective clinical trial employed a double-blind, randomized, placebo-controlled design. All consecutive cancer patients who met the inclusion criteria were enrolled in the oncology ward of Imam Khomeini Hospital, Urmia, Iran. Patients were randomly allocated to one of two groups: one receiving L-Carnitine 1000 mg three times daily (total dose 3000 mg/day) and the other receiving a placebo. Mucositis severity was evaluated clinically using the WHO scoring system every week throughout the 21-day study period. Results: L-carnitine supplementation did not significantly reduce the incidence of mucositis compared to placebo (p-value = 0.748). Among the 40 enrolled patients, exactly half (50%) developed mucositis. As per the WHO grading system, the distribution of mucositis severity was as follows: 15% for grade 1, 30% for grade 2, and 5% for grade 3. Notably, no patients experienced grade 4 mucositis, the most severe category. Grade 2 mucositis represented the most common presentation, affecting 29.2% of the placebo group and 31.3% of the L-Carnitine group. Conclusion: Our investigation did not identify a statistically significant impact of L-Carnitine supplementation on the incidence, severity progression, or WHO grade distribution of chemotherapy-induced oral mucositis compared to the placebo group.   ,L-Carnitine,mucositis,chemotherapy,cancer,antineoplastic drugs 0 0 http://ppj.phypha.ir/browse.php?a_code=A-10-2525-1&slc_lang=en&sid=1 2023/08/302025/01/6 1403/10/17 2024/06/152025/10/25 1404/8/3 Afshin Shiva Department of Clinical Pharmacy, School of Pharmacy, Urmia University of Medical Sciences, Urmia, Iran afshin.shiva@gmail.com 00319475328460039039 00319475328460039039 No Mahroo Ghasempour School of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada gmr.mahroo@yahoo.com 00319475328460039040 00319475328460039040 No Rahim Asghari Department of Internal Medicine, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran Rahimasghari@gmail.com 00319475328460039041 00319475328460039041 No Shima Hatamkhani Department of Clinical Pharmacy, School of Pharmacy, Urmia University of Medical Sciences, Urmia, Iran hatamkhani.sh@umsu.ac.ir 00319475328460039042 0000000241668977 Yes

en Background: Medicinal plants perform a prominent function in improving sustainable healthcare system and benefits because of enriching bioactive components in pharmacology industry. The aim for present research is to explore potential medicinal attributes of Teucrium polium L. essential oil (TEO), focusing on antioxidant, anticancer and antimicrobial attributes. Methods: Initially, TEO isolated by distillation method and existence substances such as spathulenol (12.98 %), beta-pinene (10.07 %) and germacrene B (9.21 %) identified using gas chromatography. Functional groups detected in TEO, which confirmed through Fourier transform infrared spectroscopy. Results: In addition, total phenol and flavonoids were reported 198.1 ± 4.19 mg gallic acid equivalent (GAE)/g dry weight (DW) and 56.23 ± 9 mg rutin (R)E/g DW, respectively. The promising antioxidant function of TEO was proved using achieved IC50 from 2,2-diphenyl-1-picrylhydrazyl (94.35 ±3.2 μg/mL), 2,2'-azino-bis-3-ethylbenzothiazoline-6-sulfonic acid (83.3 ± 5.1 μg/mL) and ferric ions (Fe3+) reducing antioxidant power (2.8 ± 0.02 μg ascorbic acid equivalent (AAE)/g). Additionally, an acceptable cytotoxicity detected by TEO according to obtained results. The lowest (1.8 mm) and highest (13.8 mm) inhibition zones for TEO were observed against Escherichia coli (E. coli) at a concentration of 20 mg/L and Staphylococcus aureus at 80 mg/L level in disk diffusion agar, respectively. The structure of E. coli depicted using a scanning electron microscopy evaluation after treating by TEO, which indicated several effects on membrane and denaturalization for bacterial cell. Conclusion: Overall, significant antimicrobial, antioxidant and anticancer functions of TEO suggested a candidate for further research in pharmacology industry and novel therapeutic agents.   ,Antimicrobial,Antioxidant,Anticancer,Essential oil,Teucrium polium L. 0 0 http://ppj.phypha.ir/browse.php?a_code=A-10-2567-1&slc_lang=en&sid=1 2023/08/302025/01/62025/05/4 1404/2/14 2024/06/152025/10/252025/11/2 1404/8/11 Samira Moradi Department of Food Science and Technology, Bioprocessing and Biodetection Laboratory, University of Tehran, Karaj, Iran Samira.moradi@ut.ac.ir 00319475328460037216 00319475328460037216 No Marjan Nouri Department of Food Science and Technology, Ro. C., Islamic Azad University, Roudehen, Iran marjan.nouri@ut.ac.ir 00319475328460037217 00319475328460037217 Yes

en Background Parkinson’s disease (PD) is commonly characterised by motor movement deterioration and cognitive impairment. Salsolinol, a dopamine-derived endogenous neurotoxin, may contribute to PD pathogenesis due to its structural and chemical similarity to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). However, the precise molecular mechanisms of the neurotoxin remain unexplored. Hence, this study aimed to evaluate the toxic effects of salsolinol on SH-SY5Y neuronal cells, focusing on mitophagy and its associated pathways. Methods SH-SY5Y cells were exposed to salsolinol for toxicity assessment using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, and inhibitory concentrations (ICs) were determined for the following assays. Induction of autophagy and mitophagy in the salsolinol-treated SH-SY5Y cells was detected with acridine orange and Mtphagy Dye, respectively. Additionally, an enzyme-linked immunosorbent assay (ELISA) was performed to determine the protein levels of the PINK1/PARKIN-mediated mitophagy pathway and the receptor-mediated mitophagy pathway in salsolinol-treated SH-SY5Y cells. Results Results reveal that SH-SY5Y cells, when treated with salsolinol (0 to 400 μM) for 24 and 48 hours, significantly elicited dose-dependent neurotoxicity. The upregulation of autophagy and mitophagy coincided with increased levels of proteins related to the PINK1/PARKIN-mediated mitophagy pathway and the receptor-mediated mitophagy pathway when treated with IC50 and IC75 as compared to untreated (UT) and IC25. Conclusion Our findings suggest that salsolinol induces mitophagy via the PINK1/PARKIN-mediated mitophagy and receptor-mediated mitophagy pathways. Parkinson's disease,Salsolinol,Mitophagy,PINK1,PARKIN 0 0 http://ppj.phypha.ir/browse.php?a_code=A-10-2568-2&slc_lang=en&sid=1 2023/08/302025/01/62025/05/42025/05/6 1404/2/16 2024/06/152025/10/252025/11/22025/12/20 1404/9/29 Shi Hong Zhang UNSW 00000034540@student.imu.edu.my 00319475328460038058 00319475328460038058 No Chooi Ling Lim IMU University chooi_linglim@imu.edu.my 00319475328460038059 00319475328460038059 No Yong Qi Leong Monash University Malaysia yong.leong@monash.edu 00319475328460038060 00319475328460038060 No Soi Moi Chye IMU University chye_soimoi@imu.edu.my 00319475328460038061 00319475328460038061 No Yin Yin Ooi IMU University YinYin.Ooi@taylors.edu.my 00319475328460038062 00319475328460038062 No Anna Pick Kiong Ling IMU University anna_ling@imu.edu.my 00319475328460038063 00319475328460038063 No Kenny Gah Leong Voon University of Nottingham Kenny.Voon@nottingham.edu.my 00319475328460038064 00319475328460038064 No Rhun Yian Koh IMU University rhunyian_koh@imu.edu.my 00319475328460038065 00319475328460038065 Yes

en Background: Peripheral nerves have limited self-restoration ability, but targeted nerve regeneration can be increased by growth factors and stem cells. This study investigated the effects of umbilical cord stroma stem cells grown on nano poly lactic-co-glycolic acid (PLGA) scaffolds of Cichorium intybus L. to repair severed sciatic nerve of male Wistar rats. Materials methods: Isolation of umbilical cord stroma stem cells, and primary culture was done. After extracting from Cichorium intybus L., a PLGA scaffold was fabricated. 45 male Wistar rats (230-260 g) were divided into 9 groups (G1= healthy control, G2=sciatic nerve injury(sni), G3=sni treated with umbilical cord cells(ucc), G4= snj treated with Cichorium intybus L(cil), G5= snj treated with cil.+ ucc, G6 = snj treated with cil +PLGA scaffold, G7=snj with PLGA scaffold, G8= snj treated with PLGA scaffold+ucc, G9= snj treated with cil + PLGA scaffold+ ucc. After eight weeks of treatment, the evaluation of sciatic nerve damage repair included electrophysiological, sciatic functional index and Other indicators examination. Results: In the group treated with cil.+PLGA +ucc, sciatic nerve repair was observed with an increase in nerve conduction velocity (m/s), amplitude muscle action potential (mv), number of (vessels and fiber), most significant area of vessels, myeline, axon, and fiber (1000 micro m2) and a decrease in statistic functional index (0 to -50) (P<0.0001). Conclusion: The transplantation of ucc leads to the repair of the severed sciatic nerve. Also, the PLGA acts as a scaffolding to place cord stem cells and cil by reducing inflammation caused by surgery.     Cichorium intybus L.,mesenchymal stem cells,poly lactic-co-glycolic acid scaffold,sciatic nerve,neural repair 0 0 http://ppj.phypha.ir/browse.php?a_code=A-10-2633-1&slc_lang=en&sid=1 2023/08/302025/01/62025/05/42025/05/62025/09/29 1404/7/7 2024/06/152025/10/252025/11/22025/12/202025/12/24 1404/10/3 amirhosein fazlali PhD student of Cell Biology - Islamic Azad University - Science and Research Branch-Tehran, Iran ahfazlali@ahoo.com 00319475328460039064 00319475328460039064 No Nasim Hayati-Roodbari Associate Professor, Department of Cell Biology, Faculty of Basic Sciences, Islamic Azad University,Research Branch, Tehran, Iran. hayati@srbiau.ac.ir 00319475328460039065 00319475328460039065 Yes Gholam Reza Kaka Professor of Anatomy, Baqiyatallah University of Medical Sciences - Tehran, Iran gh_kaka@yahoo.com 00319475328460039066 00319475328460039066 No KAZEM PARIVAR Professor, Department of Cellular Developmental Biology, Faculty of Basic Sciences, Islamic Azad University - Science and Research Branch - Tehran, Iran k.parivar@srbiau.ac.ir 00319475328460039067 00319475328460039067 No Mohammad Kamalinejad Expert in Pharmacognosy Department, Faculty of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran mkamalinejad@yahoo.com 00319475328460039068 00319475328460039068 No

en Introduction/Background: Ischemic stroke and brain trauma are significant causes of death and disability in the West. Inflammasomes induce pro-inflammatory cytokine production in cerebral ischemia, thereby driving inflammation. The current study investigates the effects of glutamic acid, N-methyl-D-aspartate receptor agonist, and SH-SY5Y Neuroblastoma-Derived Exosomes in the rat model of cerebral ischemia. Methods: Sixty adult male Wistar rats were randomly assigned to five groups. After MCAO, rats were treated with glutamic acid, SH-SY5Y neuroblastoma-derived exosomes, and both. The Garcia scale measured neurological damage 7 days after ischemia. We counted cell deaths in the brain using crystal violet staining. We examined gene and protein levels of BDNF, NLRP3, and NMDAR in brain tissue using real-time PCR and immunohistochemistry. The study used TTC staining to determine infarct cell volume in brain tissue, and ELISA tests to measure IL-1β and IL-18 levels. Results: Cresyl violet staining demonstrated that glutamic acid+exosomes substantially reduced neurodegeneration. Garcia’s test results showed that glutamic acid, independently or in combination with exosomes, significantly enhanced the function of sensory and movement regions. The results clearly indicated that the expression of the BDNF gene and protein, as well as the NMDAR gene, increased, whereas the expression of the NLRP3 gene and protein, and the Caspase-1 protein, decreased. ELISA results showed a significant drop in IL-1β and IL-18 levels in MCAO groups treated with glutamic acid, exosomes, or both.  Conclusion: The use of glutamic acid with SH-SY5Y nueroblastoma-derived exosome exerts neuroprotective benefits by enhancing neurotorophic factors and diminishing apoptosis in the MCAO model.    Brain Ischemia,Glutamic Acid,Exosomes,NLRP3 Inflammasome,Caspase-1 0 0 http://ppj.phypha.ir/browse.php?a_code=A-10-2519-1&slc_lang=en&sid=1 2023/08/302025/01/62025/05/42025/05/62025/09/292024/12/14 1403/9/24 2024/06/152025/10/252025/11/22025/12/202025/12/242026/02/1 1404/11/12 Mehrshad Mohammadzadeh Department of Pharmacology, Ka.C., Islamic Azad University, Karaj, Iran mehrshadapid@yahoo.com 00319475328460038768 00319475328460038768 No Zohreh Abdolmaleki Department of Pharmacology, Ka.C., Islamic Azad University, Karaj, Iran Zohreh.abdolmaleki@iau.ac.ir 00319475328460038769 00319475328460038769 Yes Ali Karimi Goudarzi Department of Physiology, Ka.C., Islamic Azad University, Karaj, Iran Ali.Karimi@iau.ac.ir 00319475328460038770 00319475328460038770 No Seyed mohammadreza Bolandi Department of Pharmacology, Ka.C., Islamic Azad University, Karaj, Iran Mreza.bolandi@gmail.com 00319475328460038771 00319475328460038771 No

en Background: Despite various treatment methods, the damaged peripheral nervous system has become a severe problem in today's societies. Objectives: This study aimed to evaluate the effects of cultured bone marrow stromal cells (BMSCs) on the chitosan-gelatin membrane and olive fruit extract in Wistar rat cutaneous sciatic nerve repair. Methods: The chitosan-gelatin membrane was prepared after extraction of olive and extraction of BMSCs and cultivation in special pellets. Wistar rats were divided to 9 groups (n=5): healthy control, sciatic nerve injury(sni), sni treated with bone marrow stromal stem cells, sni treated with olive fruit extract, sni treated with olive fruit extract+bone marrow stromal stem cells, sni treated with olive fruit extract+chitosan-gelatin, sni treated with chitosan-gelatin+ bone marrow stromal stem cells, and sni treated with olive fruit extract+chitosan-gelatin+ bone marrow stromal stem cells. The treatment period was 8 weeks, then the evaluation of sni repair included electrophysiological, sciatic functional index, tissue sampling and immunocytochemistry, and histopathological examination. Results: In the group treated with olive fruit extract +chitosan-gelatin+ bone marrow stromal stem cells, sciatic nerve repair was observed with an increase in nerve conduction velocity (m/s), amplitude muscle action potential (mv), number of (vessels and fiber), most significant area of vessels, myeline, axon, and fiber (1000 micro m2) and a decrease in statistic functional index (0 to -50) (P<0.0001). Conclusion: The combination of olive extract, chitosan-gelatin, and bone marrow stromal stem cells (BMSCs) demonstrated a significant reparative effect on sciatic nerve injury and could serve as a promising approach for peripheral nerve repair.   Peripheral nervous system,Sciatic nerve,Chitosan-gelatin scaffold,Olive fruit extract,Bone marrow stromal stem cells 0 0 http://ppj.phypha.ir/browse.php?a_code=A-10-2636-1&slc_lang=en&sid=1 2023/08/302025/01/62025/05/42025/05/62025/09/292024/12/142025/10/2 1404/7/10 2024/06/152025/10/252025/11/22025/12/202025/12/242026/02/12026/02/9 1404/11/20 mostafa moazami PhD student of Cell Biology - Islamic Azad University - Science and Research Branch-Tehran, Iran mostafamoazami1986@gmail.com 00319475328460039069 00319475328460039069 No Nasim Hayati-Roodbari Department of Cell Biology, Faculty of Basic Sciences, Islamic Azad University,Research Branch, Tehran, Iran. hayati@srbiau.ac.ir 00319475328460039070 00319475328460039070 Yes KAZEM PARIVAR Professor, Department of Cellular Developmental Biology, Faculty of Basic Sciences, Islamic Azad University - Science and Research Branch - Tehran, Iran k.parivar@srbiau.ac.ir 00319475328460039071 00319475328460039071 No Mohammad Kamalinejad Expert in Pharmacognosy Department, Faculty of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran mkamalinejad@yahoo.com 00319475328460039072 00319475328460039072 No gholamreza kaka Gholamreza KakaProfessor of Anatomy andNeuroscience Research Center, Baqiyatallah University of Medical Sciences, gh-kaka@yahoo.com 00319475328460039073 00319475328460039073 No

en Introduction: In diabetic patients, high blood sugar levels provoke sustained inflammation in cardiac tissue and impair normal cardiac activity. Considering the anti-diabetic characteristics of endurance training and Urtica Dioica (UD) extract, this study evaluated their potential in modulating TLR-4 levels and the inflammatory condition of cardiac tissue in diabetic Wistar rats. Methods: In the present study, a total of 50 male Wistar rats were randomly allocated into 5 equal groups: Healthy-Control (H-C), Diabetic-Control (D-C), Diabetic-Exercise (D-Ex), Diabetic-Urtica Dioica (D-UD), and Diabetic-Exercise-Urtica Dioica (D-Ex-UD). Diabetes was induced by an intraperitoneal injection of streptozotocin (STZ) (45 mg/kg). Two weeks post-STZ injection, a moderate-intensity treadmill running regimen (five days/week) performed, and UD extract (50 mg/kg) was given per day by gavage for 6 weeks. Results: A six-week regimen of exercise and UD extract improve diabetes-induced weight loss. They also resulted in a significant decrease in blood glucose of the D-Ex (P = 0.001), D-UD (P = 0.001), and D-Ex-UD (P = 0.001) groups relative to D-C. Moreover, these interventions alone and in interaction resulted in a decrease in TLR-4 and TNF-α levels, as well as an increase in IL-10 levels in cardiac tissue. However, the D-Ex-UD group indicated the most excellent effectiveness in reducing TLR-4 levels and improving the cardiac inflammatory profile (IL-10/TNF-α ratio). Conclusion: EX and UD extract reduce myocardial inflammation by modulating the TLR-4 pathway and restoring the balance of inflammatory cytokines, such that the combined intervention, through simultaneous targeting of inflammatory pathways, exerts a stronger effect than either intervention alone.   Endurance exercise,Urtica Dioica,Inflammation,cardiac tissue,Diabetes 0 0 http://ppj.phypha.ir/browse.php?a_code=A-10-2622-1&slc_lang=en&sid=1 2023/08/302025/01/62025/05/42025/05/62025/09/292024/12/142025/10/22025/09/15 1404/6/24 2024/06/152025/10/252025/11/22025/12/202025/12/242026/02/12026/02/92026/04/19 1405/1/30 setareh amiri M.A. in Exercise Physiology, Department of Exercise Physiology and Corrective Exercises, Faculty of Sport Sciences, Urmia University, Urmia, Iran se.amiri@urmia.ac.ir 00319475328460039074 00319475328460039074 No Mohammadreza Zolfaghardidani Associate Professor of Exercise Physiology, Department of Exercise Physiology and Corrective Exercises, Faculty of Sport Sciences, Urmia University, Urmia, Iran m.didani@urmia.ac.ir 00319475328460039075 00319475328460039075 Yes masoud rahmati Professor of Exercise Physiology, Department of Exercise Physiology, Faculty of Literature and Humanities, Lorestan University, Khorramabad, Iran rahmati.mas@lu.ac.ir 00319475328460039076 00319475328460039076 No ghafour ghaffari Ph.D. in Exercise Physiology, Department of Exercise Physiology and Corrective Exercises, Faculty of Sport Sciences, Urmia University, Urmia, Iran gh.ghaffari@urmia.ac.ir 00319475328460039077 00319475328460039077 No

en Introduction: Mental rotation (MR) of body parts relies not only on visuospatial processing but also on motor imagery mechanisms involving premotor cortical areas. Therefore, impairment in MR tasks may reflect both cognitive and motor dysfunction. We studied whether there is an impairment in reaction time and response accuracy rate of foot mental rotation (FMR), Paced Auditory Serial Addition (PASAT) score and walking time in individuals with relapsing-remitting multiple sclerosis (RRMS). The study also examined potential links between walking duratioN, FMR, and PASAT accuracy. Methods: Basic procedures: 37 RRMS patients and 40 healthy subjects performed FMR tasks, Physical activity and auditory information processing were assessed by Timed25-Foot Walk (T25-FW) and PASAT tests. Results: The average reaction time to stimuli of both legs and walking time in the RRMS group significantly increased compared with control group. The mean PASAT score of control group was significantly higher than the RRMS. There was no notable correlation between walking time and response accuracy rate in FMR task. Meanwhile there was a negative correlation between walking time and the number of correct responses in PASAT and positive correlation between walking time and reaction time in FMR. Conclusions: The present study demonstrates that RRMS patients exhibit significant impairments in both motor and cognitive performance compared with healthy subjects. These findings suggest that RRMS affects not only motor functions but also cognitive-motor integration processes such as MR. These findings suggest that rehabilitation especially a combination of motor imagery exercises and physical therapy may help walking improvement in RRMS.   Multiple sclerosis,Foot Mental Rotation,Motor imagery,Walking Time.,Paced Auditory Serial Addition 0 0 http://ppj.phypha.ir/browse.php?a_code=A-10-2590-1&slc_lang=en&sid=1 2023/08/302025/01/62025/05/42025/05/62025/09/292024/12/142025/10/22025/09/152025/07/16 1404/4/25 2024/06/152025/10/252025/11/22025/12/202025/12/242026/02/12026/02/92026/04/192026/05/13 1405/2/23 Faezeh Esmaeili Ranjbar Molecular Medicine Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran esmaili.faezeh@gmail.com 00319475328460039078 00319475328460039078 No Zahra Assadollahi Department of Epidemiology and Biostatistics, School of Public Health, Rafsanjan University of Medical Sciences, Rafsanjan, Iran, Department of Epidemiology and Biostatistics, School of Public Health, Kerman University of Medical Sciences, Kerman, Iran asadollahi.zahra@gmail.com 00319475328460039079 00319475328460039079 No MohmmadJavad Ranjbarkarimi Student Research Committee, Rafsanjan University of Medical Sciences, Rafsanjan, Iran m.j.ranjbar76@gmail.com 00319475328460039080 00319475328460039080 No Fatemeh Toyserkani Student Research Committee, Rafsanjan University of Medical Sciences, Rafsanjan, Iran faateemeehTooyserkani@gmail.com 00319475328460039081 00319475328460039081 No Zeinab Heidari Vice President of Health, Rafsanjan University of Medical Sciences, Rafsanjan, Iran faezeh_esmaili@yahoo.com 00319475328460039082 00319475328460039082 No Fatemeh ayoobi Occupational Safety and Health Research Center, NICICO, World Safety Organization and Rafsanjan University of Medical Sciences, Rafsanjan, Iran ayoobi.fatemeh@gmail.com 00319475328460039083 00319475328460039083 No Mostafa Hadavinejad Department of Management, Faculty of Administrative Sciences & Economy, Vali-e-Asr University, Rafsanjan, Iran hadavinejad@gmail.com 00319475328460039084 00319475328460039084 No Mahdieh Azin Physiology-Pharmacology Research Center, Research Institute on Basic Sciences, Department of Physiology and Pharmacology, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran mahdieh.azin@gmail.com 00319475328460039085 0000000341117806 Yes