2024-03-29T15:48:54+03:30
http://ppj.phypha.ir/browse.php?mag_id=48&slc_lang=en&sid=1
48-820
2024-03-29
10.1002
Physiology and Pharmacology
Physiol Pharmacol
24765236
24765244
10.61186/phypha
2012
15
4
The necessity of strategy planning for research development in different fields of physiology and pharmacology, revising the scientific structure of congresses, and using a common language for research methodology: three suggestions after 20thIranian congress of Physiology and Pharmacology
Mehdi
Nematbakhsh
nematbakhsh@gmail.com
The submitted articles to Iranian congress of physiology and pharmacology could be analyzed for the distribution of
research in different fields. Based on field distribution of articles in 20th congress, it seems that a strategic planning for
research development in the field of physiology and pharmacology is essential. It is also suggested to revise the
congress scientific structure, and to use a common language for research methodology.
Common language for research methodology
20th Iranian congress of Physiology and Pharmacology
2012
1
01
455
460
http://ppj.phypha.ir/article-1-820-en.pdf
48-767
2024-03-29
10.1002
Physiology and Pharmacology
Physiol Pharmacol
24765236
24765244
10.61186/phypha
2012
15
4
Effect of intravenous injection of progesterone and its co-administration with growth hormone and morphine on ghrelin concentration in ewes with food restriction
nastaran
azarbar
n.azarbar@yahoo.com
homayoun
khazali
hkhazali@hotmail.com
Hasan
Rokni
Introduction: Ghrelin increases growth hormone secretion and food intake. Growth hormone (GH), steroid
hormones and opioids are involved in the regulation of food intake. So, they may have a role in the regulation of ghrelin
secretion. We determined the effect of intravenous injections of progesterone, GH and morphine or co-administration of
these hormones on ghrelin concentration and body weight in sheep with food deprivation.
Methods: Ten sheep (weighing 30-35 kg) were randomly divided into 2 groups that received either 50% or 100% of
their diet for 10 days. Both groups on days 7, 8, 9 and 10 received progesterone (1mg), simultaneous injection of
progesterone (1mg) and GH (0.01mg), simultaneous injection of progesterone (1mg) and morphine (1mg) or coadministration
of progesterone (1mg), GH (0.01mg) and morphine (1mg) via jugular vein, respectively. Blood samples
were taken before injection and 2 h after injection via jugular vein. Body weight was measured on first, 7th and 10th days
of experiment. Serum ghrelin concentration was measured by RIA.
Results: Results showed that food deprivation increased ghrelin concentration. Also, intravenous injection of
progesterone reduced ghrelin concentration in sheep and this reduction was significant in ad libitum (P<0.05).
Simultaneous injection of progesterone and GH, simultaneous injection of progesterone and morphine or coadministration
of progesterone, GH and morphine significantly increased ghrelin concentration in both groups (P<0.05).
Conclusion: Progesterone-induced increase in appetite is not due to ghrelin. Injection of progesterone (1mg)
decreased ghrelin concentration, but simultaneous injection of progesterone (1mg) and growth hormone (0.01mg)
increased it.
Ghrelin
Progesterone
Growth hormone
Morphine
Sheep
2012
1
01
461
469
http://ppj.phypha.ir/article-1-767-en.pdf
48-755
2024-03-29
10.1002
Physiology and Pharmacology
Physiol Pharmacol
24765236
24765244
10.61186/phypha
2012
15
4
Effect of acute exposure to ethanol on distribution of NR1 subunit of NMDA receptor of glutamate in cerebral cortex of chick embryo
Mahnaz
Taherianfard
taherian@shirazu.ac.ir
Bita
Geramizadeh
Maryam
Nasek
Maryam
Sharifi
Introduction: There is considerable evidence that glutamate-mediated excitatory neurotransmission plays an
important role in mediating the behavioral actions of acutely administered ethanol. The aim of the present study was to
investigate the effect of acute ethanol exposure on NR1 subunit of NMDA (n-methyl-d-aspartate) receptor distribution
in the cerebral cortex of chick embryo on the 10th and 15th day of egg incubation.
Methods: Forty fertilized eggs were divided in two groups control and ethanol (70% ethanol). In both groups, on
the 10th and 15th days of embryonic stage, brain coronal sections were prepared for determination of distribution of
NMDA receptor NR1 subunit by immunohistochemical method. Image analyzer software was used for color analysis.
Results: Immunohistological findings of these experiments indicated that acute exposure to ethanol significantly
decreased the density of NMDA receptors NR1 subunits in chick brain on the 10th and 15th day of the embryonic stage.
Also, the ratio of the number of NMDA receptor NR1subunit to immunoreactive cells were significantly decreased in
acute ethanol groups.
Conclusion: Our results indicated that acute exposure to ethanol decrease NR1 receptor distribution and the ratio of
the number of NMDA receptor NR1 subunit to immunoreactive cells in the brain of chick embryo on the 10th and 15th
day of embryonic stage.
Acute Ethanol
NR1 Receptor
Chick Embryo
2012
1
01
470
477
http://ppj.phypha.ir/article-1-755-en.pdf
48-751
2024-03-29
10.1002
Physiology and Pharmacology
Physiol Pharmacol
24765236
24765244
10.61186/phypha
2012
15
4
Evaluation of the effects of taurine on cisplatin-induced kidney injury and oxidative stress in male rats
maryam
noruzi
mery_noruzi@ymail.com
samad
zareh
Introduction: Cisplatin is used as a chemotherapeutic agent for the treatment of human ovarian and testicular
cancers. This study was designed to investigate the protective role of taurine against cisplatin-induced kidney injury.
Methods: Male Wistar rats were divided into 4 groups (n=8) (1) saline-treated group (2) cisplatin-treated group (10
mg/kg, i.p.), (3) group that received taurine (200 mg/kg, i.p) 1 hr before cisplatin (10 mg/kg, i.p) administration and (4)
taurine treated group (200 mg/kg, i.p). The treatment period was 7 days. Animals were then weighed and blood samples
were collected from the heart. After sacrifice, kidneys were removed and kept at -70 °C until further analyses.
Results: Cisplatin significantly elevated the creatinine and blood urea nitrogen (BUN) serum levels (P<0.05). Pretreatment
with taurine resulted in a remarkable reduction of these markers. The catalase activity in cisplatin-treated rats
was significantly decreased (P<0.05) and taurine administration could remarkably recover this decreased activity.
Malondialdehyde (MDA) content of the kidneys was increased in cisplatin-exposed animals and taurine significantly
reduced the amount of MDA.
Conclusion: Our data suggest that pretreatment with taurine might be considered as a protective approach in
cisplatin-induced nephrotoxicity.
cisplatin
taurine
kidney injury
rat
2012
1
01
478
485
http://ppj.phypha.ir/article-1-751-en.pdf
48-789
2024-03-29
10.1002
Physiology and Pharmacology
Physiol Pharmacol
24765236
24765244
10.61186/phypha
2012
15
4
Effect of glial inhibition in attenuation of neuropathic pain and improvement of morphine analgesic effect in a rat model of neuropathy
samad
nazemi
samadnazei@gmail.com
homa
manaheji
hshardimanaheji@yahoo.com
Abbas
Haghparast
Haghparast@yahoo.com
Jalal
Zaringhalam moghadam
jzaringhalam@yahoo.com
mehdi
sadegi
nazemphy@yahoo.com
Introduction: Pharmacological blockage of glial activity has been proved useful for treatment of neuropathic pain
by lowering proinflammatory cytokines. The present study is to confirm the effect of post-injury administration of
pentoxifylline on chronic constriction injury (CCI)-induced neuropathic pain symptoms_ and improved the efficacy of
morphine anti-nociception.
Methods: Male Wistar rats (230-270 g) underwent surgery for induction of CCI model of neuropathy. In the sham
group the nerve was exposed but not ligated. In 5 groups (n=8) morphine (2.5, 5, 7.5, 10, 15 mg/kg s.c.) was
administered in post-operative days (POD) 0, 6 and 14. To evaluate the analgesic effect of different doses of morphine,
Von Frey and Hargreaves tests were performed before and 30 minutes after morphine administration. In different
groups, pentoxifylline (8, 15, 30 mg/kg i.p.) or normal saline (vehicle) were administered from POD6 to POD13.
Behavioral tests were utilized after last dose of pentoxifylline and also on POD14 again after injection of a single dose
of morphine (5 mg/kg, s.c.).
Results: The analgesic effect of morphine (5 mg/kg) on POD6 and morphine (5, 7.5, 10, 15 mg/kg) on POD14 was
significantly decreased in comparison to POD0. Pentoxifylline effectively attenuated thermal hyperalgesia (at 15 and 30
mg/kg) and mechanical allodynia (at 30 mg/kg) on POD13. However, pentoxifylline (15, 30 mg/kg) improved the antihyperalgesic
effect of morphine (5 mg/kg s.c.) on POD14.
Conclusion: Analgesic effect of morphine was reduced after nerve injury and it may be due to the activation of glia.
Inhibition of glial activity is an effective way to attenuate CCI-induced neuropathic pain and also to improve the antihyperalgesic
effect of morphine, without significant effect on its anti-allodynic effect.
Neuropathic pain
Glia
Morphine
Allodynia
Hyperalgesia
2012
1
01
486
498
http://ppj.phypha.ir/article-1-789-en.pdf
48-738
2024-03-29
10.1002
Physiology and Pharmacology
Physiol Pharmacol
24765236
24765244
10.61186/phypha
2012
15
4
Effects of endogenous production and exogenous administration of H2S on gastric acid secretion in rats
seyyed Ali
Mard
alimard77@gmail.com
Maryam
Maleki
maryammaleki777@yahoo.com
Mohammad Kazem
Gharib Naseri
gharibnaseri_m@yahoo.com
Alihosein
Saberi
Introduction: Recently, hydrogen sulfide has been introduced as the third gas that acts as a transmitter. It has many
physiological and pharmacological roles in the human body. The aim of the present study was to investigate the effect
of exogenously administered and endogenously produced H2S on the basal and distention-induced gastric acid secretion
in rats.
Methods: Forty-nine male Wistar rats (150-200 g) were randomly assigned into 7 groups (7 rats per group). To
evaluate the effect of H2S on the basal acid secretion, three groups of animals received an IV bolus of NaHS, a H2S
donor, at the doses of 20, 40 or 80 μg/Kg. The effects of IV NaHS 20, 40 or 80 μg/Kg were also investigated on
distention-induced gastric acid secretion in other three groups. In order to evaluate the effect of endogenously produced
H2S on distention-induced gastric acid secretion, one group of animals received IV propargylglycine (PAG), a
cystathionine-γ-lyase inhibitor, 100 mg/kg.
Results: NaHS decreased the basal and distention-induced gastric acid secretion in a dose-dependent manner
(P<0.01). PAG increased the gastric output in response to distention compared to the control group (P<0.001).
Conclusion: Our results showed that both exogenous administration and endogenous production of H2S decrease
the gastric acid output. Also, the findings of the present study suggest that endogenously produced H2S has a
modulatory effect on stimulated gastric acid output similar to nitric oxide (NO).
gastric acid output
NaHS
PAG
rat
2012
1
01
499
506
http://ppj.phypha.ir/article-1-738-en.pdf
48-741
2024-03-29
10.1002
Physiology and Pharmacology
Physiol Pharmacol
24765236
24765244
10.61186/phypha
2012
15
4
Acute direct effects of cyclosporine on extracellular field potential of isolated rabbit AV node during experimental atrial fibrillation
Vahid
Khori
vaph99@yahoo.com
Samaneh
Naeimipour
shariat@yahoo.com
Alimohammad
Alizadeh
Ali
Haeri Rouhani
Mona
Pourabouk
abook_8181@yahoo.com
Fakhri
Badaghabadi
nazari_2005@yahoo.com
Maryam
Rajaei
Sepideh
Shariatnezhad
Hamidreza
Moheimani
Saeed
Saleki
Mohammad Ali
Zeyghami
Mohsen
Nayebpour
vaph99@yahoo.com
Introduction: Previous studies have indicated a relationship between MPTP pore and AV nodal rate-dependent
properties. The aim of present study was to determine acute direct effects of cyclosporine on extracellular field potential
of isolated rabbit AV node during experimental atrial fibrillation.
Methods: In one group of male New Zealand rabbits (1.5-2.5 kg) cumulative concentrations of cyclosporine (0.5 –
10 m) were applied on isolated perfused atrio-nodal preparation (n=7). Extracellular field potential recording was
sampled during specific stimulation protocols (recovery, zone of concealment and atrial fibrillation) in the presence of
drug on electrophysiological properties of AV-node.
Results: Cyclosporine significantly decreased the ventricular rate (HH mean) from 231.8 ± 5.7 to 277.4 ± 14.6 msec
and functional refractory period during AF (AF FRP) from 138.3 ± 7.5 to 161.2 ± 10.31 msec in control and treated
groups, respectively. Effective refractory period during AF (AF ERP) was significantly decreased by cyclosporine 10
mM compared to control group (p<0.05).
Conclusion: Cyclosporine-evoked slowing ventricular heart rate during AF was induced by increasing functional
refractoy period and ZOC. A possible mechanism can be through blocking of MPT pores.
Atrio-ventricular node
Cyclosporine
mitochondrial permeability transitional pores
atrial fibrillation
2012
1
01
507
516
http://ppj.phypha.ir/article-1-741-en.pdf
48-733
2024-03-29
10.1002
Physiology and Pharmacology
Physiol Pharmacol
24765236
24765244
10.61186/phypha
2012
15
4
Effects of twelve weeks of resistance training on the resting levels of cardiac and related hormones in healthy men
Sajad
Ahmadizad
Saleh
Zahediasl
zahedi@endocrine.ac.ir
Seyed Mortaza
Sajadi
Khousro
Ebramin
Minoo
Bassami
Introduction: Heart secretes hormones such as natriuretic peptide. The purpose of this study was to investigate the
effects of 12 weeks of resistance training on these hormones.
Methods: Twenty four healthy men (Mean age ± SD: 24.9 ± 3.2 years) were randomly allocated to experimental
and control groups. Subjects in the experimental group performed a 12-week resistance training program, 3 sessions per
week at an intensity between 55 to 75% of maximum strength. Each session of training included three sets of 10
repetitions for 8 exercises of upper and lower body. Two blood samples were taken before and 48 hours after training
period for measuring ANP, BNP, endothelin-1 and angiotensin II.
Results: Resting values of ANP before and after 12 weeks of training for experimental group were 0.87±0.22 and
0.89±0.30 nmol/L, respectively, while these values for control group were 0.92±0.30 and 0.92±0.31 nmol/L,
respectively. Data analysis revealed no significant difference between the effects of training on resting levels of ANP,
BNP, endothelin-1 and angiotensin II in two groups (P>0.05). In addition, no significant difference between pre- and
post-training values of ANP and BNP was observed when data were separately compared in each group.
Conclusion: Based on the findings of the present study, it could be concluded that resistance training does not
induce changes in resting levels of cardiac hormones (ANP and BNP), and that beneficial changes induced by exercise
training might not be due to changes in these parameters.
Weight training
ANP
BNP
angiotensin II
endothelin-1
2012
1
01
517
526
http://ppj.phypha.ir/article-1-733-en.pdf
48-754
2024-03-29
10.1002
Physiology and Pharmacology
Physiol Pharmacol
24765236
24765244
10.61186/phypha
2012
15
4
Aerobic activity improves spatial learning and motor activity in aged rats
Nassour
Ahmadi
nassour_a@yahoo.com
Aslankhani
Mohammad Ali
M-Aslankhani@sbu.ac.ir
Nasser
Naghdi
naghdi@pasteur.ac.ir
Aging has negative effects on motor and cognitive functions, therefore finding appropriate strategies
to prevent the decline of these functions is necessary. It seems that cardiovascular fitness obtained by aerobic activity is
a physiological mediator that explains the relationship between physical activity and improved cognitive performance.
The aim of this research was to assess the effects of aerobic activity on spatial learning and motor activity in aged rats.
Methods: 24 Albino Wistar healthy aged male rats were randomly divided into control (weight: 458±34 grams) and
aerobic activity (weight: 443±40 grams) groups. Aerobic activity group ran 8 weeks on treadmill according to Brooks et
al. (1984) protocol. After the end of physical activity period, Morris Water Maze and open-field tests were performed to
assess spatial learning and motor function, respectively. Latency and distance moved to find platform were used as
criteria of spatial learning, while distance moved, mobility duration and movement speed were used as criteria of motor
function.
Results: In spatial learning, aerobic activity group performed better in acquisition (distance moved (F1,22=8.59,
p=0.004) and latency time (F1,22=7.22, p=0.007)), probe (time spent in target quadrant (t22=2.24, p=0.018)), and
retrieval tests (distance moved (t22=2.823, p=0.005) and latency time (t22=3.73, p=0.001)) compared to the control
group. Aerobic activity group performed also better in all indices of motor function including distance moved (t22=2.83,
p=0.005), mobility duration (t22=2.15, p=0.03), and movement speed (t22=2.52, p=0.01) compared to control group.
Conclusion: Results showed that aerobic activity improves spatial learning and motor function in aged rats.
Key words: rat
physical activity
motor activity
spatial memory
cognitive function
aging
2012
1
01
527
537
http://ppj.phypha.ir/article-1-754-en.pdf
48-753
2024-03-29
10.1002
Physiology and Pharmacology
Physiol Pharmacol
24765236
24765244
10.61186/phypha
2012
15
4
Effect of butylated hydroxytoluene on passive avoidance learning in male rats
Mahnaz
Taherianfard
taherian@shirazu.ac.ir
Javad
Sajedianfard
Bita
Geramizadeh
Neda
Jafari
Gelareh
Haghighatjoo
Farzaneh
Hoseinnia
Introduction: Butylated hydroxytoluene (BHT 2, 6-di-tert-butyl-p-cresol) is one of the extensively used
antioxidants in the food industry. It is used in low-fat foods, fish products, packaging materials, paraffin, and mineral
oils. BHT is also widely used in combination with other antioxidants such as BHA, propyl gallate, and citric acid for the
stabilization of oils and high-fat foods. On the other hand, some investigators have reported that BHT has psychotic
effects. Therefore, the aim of the present study was to investigate the effect of BHT on learning and memory in a model
of passive avoidance learning in male rats.
Methods: Twenty-eight male rats weighting 180-260 g were used. Animals were divided into 4 groups: 1- control
group (received sesame oil with the same volume as experimental groups) -2 experimental 1 (received BHT 25
mg/kg/day) 3- experimental 2 (received BHT 100 mg/kg/day) 4- experimental 3 (received BHT 150 mg/kg/day). BHT
was administered by oral intake for 15 days. Learning and memory were assessed by a passive avoidance shuttle-box.
Data were analyzed by one way ANOVA and Tucky's post-hoc test. The level of significant was set at P<0.05.
Results: Our data showed that BHT at the doses of 25, 100 and 150 mg/kg/day significantly decreased the time
spent in light compared to the control group.
Conclusion: According to our results, BHT impairs learning and memory in passive avoidance learning.
Butylated hydroxytoluene
learning and memory
shuttle-box
male rats
2012
1
01
538
544
http://ppj.phypha.ir/article-1-753-en.pdf
48-762
2024-03-29
10.1002
Physiology and Pharmacology
Physiol Pharmacol
24765236
24765244
10.61186/phypha
2012
15
4
Effects of social stress on pain behavior, immune cells and serum concentrations of TNF-α, Interleukin-1 and Interleukin-6 in female mice
Marjan
Aghajani
marjan_2661@yahoo.ca
Mohammad Reza
Vaez Mahdavi
mh_mahdavi@yahoo.com
Tooba
Ghazanfari
tghazanfari@yahoo.com
Mohsen
Khalili
Armin
Azimi
Saeid
Arbab Soleymani
Shirin
Mahdi Dust
Introduction: Based on human studies, inequality and social injustice have adverse effects on the individual and
community health. In this study, the effects of food intake inequality and social status changes on pain perception and
immunological factors were investigated in Balb/C mice.
Methods: The present study was conducted by implementing different social stresses including food deprivation,
food intake inequality and unstable social status (cage-mate change every 3 days) in 48 female mice. Formalin test was
performed and thereafter the viability of peritoneal macrophages and spleen lymphocytes was evaluated by MTT assay.
Concentrations of proinflammatory cytokines including IL-6, IL- 1 and TNF-α were also measured.
Results: Our results showed that the implementation of food deprivation and inequality induced significant changes
in chronic phase of formalin test compared to the control group (P<0.05). Pain perception was considerably decreased
and this decline in inequality exposed subjects was well above the isolated ones. However, unstable social situation did
not affect pain perception. Moreover, cell viability of peritoneal macrophages decreased, while cell viability of spleen
lymphocytes and proinflammatory cytokines concentrations were increased in the serum of all stressed animals in
comparison with controls (P<0.05).
Conclusion: These results revealed that although food deprivation and social inequality can induce analgesia, some
socioeconomic situations like social instability does not affect pain perception. All of these situations decrease cell
viability in macrophages but enhance cell viability in lymphocytes. It seems that a proinflammatory stress condition is
involved in these situations.
social stress
analgesia
cytokine
macrophage
lymphocyte
2012
1
01
545
561
http://ppj.phypha.ir/article-1-762-en.pdf
48-730
2024-03-29
10.1002
Physiology and Pharmacology
Physiol Pharmacol
24765236
24765244
10.61186/phypha
2012
15
4
Study of the effects of hyperglycemia and Launaea acanthodes extract administration on disorders of liver function in rats
Mitra
Jalali
m_jalali25@yahoo.com
Morteza
Behnam Rassouli
behnam@um.ac.ir
Maryam
Tehrani por
behnam@um.ac.ir
Nargess
Ghayour
behnam@um.ac.ir
Jena
Khayatzadeh
m_jalali25@yahoo.com
Hamid
Jannati
Introduction: Liver plays a pivotal role in glucose and lipid homeostasis. This study was undertaken to evaluate the
effects of L. acanthodes hydro-alcoholic extract administration on the liver functional and histological parameters in
hyperglycemic rats.
Methods: Twenty-four male Wistar rats were randomly allocated into four groups control, hyperglycemic (STZ),
hyperglycemic + insulin (STZ+Ins) and hyperglycemic + extract (STZ+Ext). After a single injection of STZ (55 mg/kg,
i.p.) and confirmation of hyperglycemia induction, rats of STZ+Ins and STZ+Ext were daily treated with insulin (5
IU/kg/day) and extract (150 mg/kg/day), respectively, for 21 days. To assess the serum levels of biochemical
parameters and liver markers, all rats were kept until the 7th week and then they were sacrificed and their livers were
histologically examined.
Results: Serum levels of ALT, AST, ALP, glucose and triglyceride in STZ and STZ+Ins groups were significantly
increased in comparison with control and STZ+Ext groups at the 2nd week. At the 4th week, although the mean levels of
liver enzymes were increased in STZ+Ext (p<0.05) but its level of significance was lower that STZ and STZ+Ins
groups (p<0.001) groups. Microscopic examination of liver sections showed no histological difference between control
and experimental samples.
Conclusion: Streptozotocin induced hyperglycemia may result in abnormal levels of liver markers. This liver
malfunction is probably caused by hepatocyte membrane damage due to the free radical production induced by
hyperglycemia. It seems that antioxidant property of flavonoids constituents of L.acanthodes, may prevent hepatocytes
damage and therefore reduce the serum levels of liver markers.
Launaea acanthodes
insulin
liver enzymes
hyperglycemia
2012
1
01
562
571
http://ppj.phypha.ir/article-1-730-en.pdf
48-719
2024-03-29
10.1002
Physiology and Pharmacology
Physiol Pharmacol
24765236
24765244
10.61186/phypha
2012
15
4
Effect of pre-treatment with oxytocin on cardiac enzymes in regional ischemiareperfusion injury induced in the rat heart
Ali Mohammad
Alizadeh
aalizadeh@razi.tums.ac.ir
Mahdieh
Faghihi
faghihim@tums.ac.ir
Vahid
Khori
vaph99@yahoo.com
Maryam
Mohsenikia
m.mohsenikia@gmail.com
Introduction: Cardiac preconditioning represents the most potent and consistently reproducible method of rescuing
heart tissue from undergoing irreversible ischemic damage. The aim of the present study was to evaluate oxytocin (OT)
induced cardioprotection and its signaling pathways on lactate dehydrogenase (LDH) and creatine kinase-MB
isoenzyme (CK-MB) in the anesthetized rats.
Methods: Eighty-four rats were divided into fourteen groups. Animal’s hearts were subjected to 25 min ischemia
and 2 h reperfusion (I/R). Oxytocin (0.03 μg/kg) was used 25 min prior to ischemia. Atosiban, an OT receptor
antagonist (1.5 μg/kg), 5-hydroxydecanoic acid, an inhibitor of mitochondrial ATP-dependent potassium channel (10
mg/kg), atractyloside, an opener of mitochondrial permeability transition pores (5 mg/kg), chelytraine, a protein kinase
C inhibitor (5 mg/kg) and N-acetylcysteine, a reactive oxygen species scavenger (200 mg/kg) were used 10 min prior to
OT administration. Then, LDH and CK-MB levels in plasma were measured.
Results: OT administration significantly decreased CK-MB and LDH levels compared to I/R group. Administration
of atosiban, 5-hydroxydecanoic, atractyloside, chelytraine and N-acetylcysteine abolished the cardiac preconditioning
effect of OT.
Conclusion: The present study demonstrates that oxytocin cardioprotective effects are complex and its signaling
pathways may mediate through mKATP channels, mPTP, PKC activation and increase ROS.
Ischemia-reperfusion
oxytocin
5-hydroxydecanoic
atractyloside
chelytraine
N-acetylcysteine
2012
1
01
572
582
http://ppj.phypha.ir/article-1-719-en.pdf