Ranjbar K, Nazari A, Nazem F. Effect of exercise training and L-arginine supplementation on oxidative stress and left ventricular function in rats with myocardial infarction. Physiol Pharmacol 2015; 18 (4) :445-454
URL:
http://ppj.phypha.ir/article-1-1036-en.html
Abstract: (5555 Views)
Introduction: The aim of the present study was to evaluate the effect of exercise training and L-arginine
supplementation on oxidative stress and systolic ventricular function in rats with myocardial infarction (MI).
Methods: Four weeks after the surgically-induced MI, 40 male Wistar rats were randomly assigned to the following
4 groups (n=10): MI-sedentary control (Sed) MI-exercise (Ex) MI-sedentary+L-arginine (Sed+LA) and MIexercise+
L-arginine (Ex+LA). The Ex and Ex+LA groups ran for 10 weeks on treadmill. Rats in the L-arginine-treated
groups drank water containing 4% L-arginine. Before and after the training program, all subjects underwent resting
echocardiography. Also catalase, glutathione peroxidase, malondialdehyde and myeloperoxidase were measured.
Results: cardiac output, stroke volume and fractional shortening in Ex and Ex+LA groups were significantly
increased compared to the Sed group. Cardiac systolic function in Ex+LA group was significantly greater than in Ex
group. Infarct size was insignificantly reduced in response to exercise. Also, glutathione peroxidase activity was
increased while malondialdehyde showed a decrease in response to exercise training, but no effect on myeloperoxidase
and catalase was noted. There was no difference in enzyme activity between the training groups.
Conclusion: Exercise training increased LV systolic function by decreasing oxidative stress and increasing
antioxidant defense system in rats with myocardial infarction. It appears that L-arginine improves left ventricular
function, but has no effect on oxidative stress indices.