Volume 26, Issue 2 (June 2022)                   Physiol Pharmacol 2022, 26(2): 104-118 | Back to browse issues page


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Akbari E, Alizadeh-Navaei R, Rouhi Ardeshiri M. Linear heart rate variability measures in sickle cell disease compared to the healthy control subjects: a systematic review and mete-analysis study. Physiol Pharmacol. 2022; 26 (2) :104-118
URL: http://ppj.phypha.ir/article-1-1645-en.html
Abstract:   (1055 Views)
Introduction: Heart rate variability represents the performance of the cardiac autonomic nervous system (ANS) and is defined as the fluctuation of beat-to-beat between two successive R-waves (RR intervals). Accordingly, addressing the actions of the ANS in sickle cell disease helps in identifying the possible risk factors of sudden death. The clinical staging of the disease improves the diagnosis and the quality of the treatments. Methods: This systematic review analyzed the data of the basal autonomic reactions in sickle cell anemia (SCA) and sickle cell trait (SCT) patients compared to healthy people. In this study, 441 articles were retrieved from PubMed, ProQuest, SCOPUS, Embase, and Web of Science databases. Some of them were removed based on the inclusion and exclusion criteria, and finally, seven articles remained for analysis. Results: The data analysis of the included studies demonstrated that the vagal modulation at the basal condition decreased in SCA or SCT patients compared to the control group. Conclusion: The sympathovagal balance was altered in SCA or SCT patients, and an increasing trend was observed in sympathetic nerve activities.
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Types of Manuscript: Review | Subject: Cardiovascular Physiology/Pharmacology

References
1. Adebiyi AA, Oyebowale OM, Olaniyi AJ, Falase AO. Heart rate variability study in adult Nigerian subjects with sickle cell disease during vaso-occlusive crisis. Niger Postgrad Med J 2019; 26: 8. [DOI:10.4103/npmj.npmj_186_18]
2. Ai J, Epstein P, Gozal D, Yang B, Wurster R, Cheng Z. Morphology and topography of nucleus ambiguus projections to cardiac ganglia in rats and mice. Neuroscience 2007; 149: 845-60. [DOI:10.1016/j.neuroscience.2007.07.062]
3. Assanasen C, Quinton RA, Buchanan GR. Acute myocardial infarction in sickle cell anemia. Pediatr Hematol Oncol J 2003; 25: 978-81. [DOI:10.1097/00043426-200312000-00015]
4. Batra AS, Acherman RJ, Wong WY, Wood JC, Chan LS, Ramicone E, et al. Cardiac abnormalities in children with sickle cell anemia. Am J Hematol 2002; 70: 306-12. [DOI:10.1002/ajh.10154]
5. Beitzke M, Pfister P, Fortin J, Skrabal F. Autonomic dysfunction and hemodynamics in vitamin B12 deficiency. Auton Neurosci 2002; 97: 45-54. [DOI:10.1016/S1566-0702(01)00393-9]
6. Bode- Thomas F, Hyacinth H, Ogunkunle O, Omotoso A. Myocardial ischaemia in sickle cell anaemia: evaluation using a new scoring system. Ann Trop Paediatr 2011; 31: 67-74. [DOI:10.1179/1465328110Y.0000000006]
7. Borenstein M, Hedges L, Rothstein H. Meta-analysis: Fixed effect vs. random effects. available at: Meta-analysis.com 2007.
8. Camm AJ, Malik M, Bigger JT, Breithardt G, Cerutti S, Cohen RJ, et al. Heart rate variability. Standards of measurement, physiological interpretation, and clinical use. Eur Heart J 1996; 17: 354-81. [DOI:10.1093/oxfordjournals.eurheartj.a014868]
9. Chalacheva P, Khaleel M, Sunwoo J, Shah P, Detterich JA, Kato RM, et al. Biophysical markers of the peripheral vasoconstriction response to pain in sickle cell disease. PloS One 2017; 12: e0178353. [DOI:10.1371/journal.pone.0178353]
10. Connes P, Barthelemy JC. Comment on 'Abnormal autonomic cardiac response to transient hypoxia in sickle cell anemia'. Physiol Meas 2008; 29: L1-2. [DOI:10.1088/0967-3334/29/9/L01]
11. Connes P, Coates TD. Autonomic nervous system dysfunction: implication in sickle cell disease. C R Biol 2013; 336: 142-7. [DOI:10.1016/j.crvi.2012.09.003]
12. de Andrade Martins W, Lopes HF, Consolim-Colombo FM, Gualandro SD, Arteaga-Fernández E, Mady C. Cardiovascular autonomic dysfunction in sickle cell anemia. Auton Neurosci 2012; 166: 54-9. [DOI:10.1016/j.autneu.2011.07.011]
13. Deymann AJ, Goertz KK. Myocardial infarction and transient ventricular dysfunction in an adolescent with sickle cell disease. Pediatrics 2003; 111: 422. [DOI:10.1542/peds.111.2.e183]
14. Kardelen F, Tezcan G, Akcurin G, Ertug H, Yesilipek A. Heart rate variability in patients with thalassemia major. Pediatr Cardiol 2008; 29: 935-9. [DOI:10.1007/s00246-008-9240-1]
15. Khaleel M, Puliyel M, Shah P, Sunwoo J, Kato RM, Chalacheva P, et al. Individuals with sickle cell disease have a significantly greater vasoconstriction response to thermal pain than controls and have significant vasoconstriction in response to anticipation of pain. Am J Hematol 2017; 92: 1137-45. [DOI:10.1002/ajh.24858]
16. Kim J, Hakim F, Kheirandish-Gozal L, Gozal D. Inflammatory pathways in children with insufficient or disordered sleep. Respir Physiol Neurobiol 2011; 178: 465-74. [DOI:10.1016/j.resp.2011.04.024]
17. Lonergan GJ, Cline DB, Abbondanzo SL. Sickle cell anemia. Radiographics 2001; 21: 971-94. [DOI:10.1148/radiographics.21.4.g01jl23971]
18. Mestre JR, Hernandez A, Agramonte O, Hernandez P. Cardiovascular autonomic dysfunction in sickle cell anemia: a possible risk factor for sudden death? Clin Auton Res 1997; 7: 121-5. [DOI:10.1007/BF02308838]
19. Michelini LC, O'Leary DS, Raven PB, Nóbrega AC. Neural control of circulation and exercise: a translational approach disclosing interactions between central command, arterial baroreflex, and muscle metaboreflex. Am J Physiol Heart Circ 2015; 309: H381-92. [DOI:10.1152/ajpheart.00077.2015]
20. Norris S, Johnson CS, Haywood LJ. Sickle cell anemia: does myocardial ischemia occur during crisis? J Natl Med Assoc 1991; 83: 209.
21. Perronne V, Roberts-Harewood M, Bachir D, Roudot-Thoraval F, Delord JM, Thuret I, et al. Patterns of mortality in sickle cell disease in adults in France and England. Hematol J 2002; 3: 56-60. [DOI:10.1038/sj.thj.6200147]
22. Peterson J, Welch V, Losos M, Tugwell PJ. The Newcastle-Ottawa scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. Ottawa: Ottawa Hospital Research Institute 2011.
23. Quinn CT, Shull EP, Ahmad N, Rogers ZR, Buchanan GR. Prognostic significance of early vasoocclusive complications in children with sickle cell anemia. Blood 2005; 106: 3176. [DOI:10.1182/blood.V106.11.3176.3176]
24. Sangkatumvong S. Modeling of cardiovascular autonomic control in sickle cell disease. University of Southern California, 2011.
25. Sangkatumvong S, Coates TD, Khoo MC. Abnormal autonomic cardiac response to transient hypoxia in sickle cell anemia. Physiol Meas 2008a; 29: 655. [DOI:10.1088/0967-3334/29/5/010]
26. Sangkatumvong S, Coates TD, Wood JC, Meiselman HJ, Kato R, Detterich JA, et al. Time-varying analysis of autonomic control in response to spontaneous sighs in sickle cell anemia. In2010 Annual International Conference of the IEEE Engineering in Medicine and Biology 2010: 1626-9. [DOI:10.1109/IEMBS.2010.5626649]
27. Sangkatumvong S, Khoo MC, Coates TD. Abnormal cardiac autonomic control in sickle cell disease following transient hypoxia. In2008 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society 2008b Aug 20, pp. 1996-9. [DOI:10.1109/IEMBS.2008.4649581]
28. Sangkatumvong S, Khoo MC, Kato R, Detterich JA, Bush A, Keens TG, et al. Peripheral vasoconstriction and abnormal parasympathetic response to sighs and transient hypoxia in sickle cell disease. Am J Respir Crit Care Med 2011; 184: 474-81. [DOI:10.1164/rccm.201103-0537OC]
29. Tsaras G, Owusu-Ansah A, Boateng F O, Amoateng-Adjepong Y. Complications associated with sickle cell trait: a brief narrative review. Am J Med 2009; 122: 507-12. [DOI:10.1016/j.amjmed.2008.12.020]
30. Wan X, Wang W, Liu J, Tong T. Estimating the sample mean and standard deviation from the sample size, median, range and/or interquartile range. BMC Med Res Methodol 2014; 14: 1-3. [DOI:10.1186/1471-2288-14-135]
31. Yokusoglu M, Nevruz O, Baysan O, Uzun M, Demirkol S, Avcu F, et al. The altered autonomic nervous system activity in iron deficiency anemia. Tohoku J Exp Med 2007; 212: 397-402. [DOI:10.1620/tjem.212.397]
32. Zygmunt A, Stanczyk J. Methods of evaluation of autonomic nervous system function. Arch Med Sci 2010; 6: 11-18. [DOI:10.5114/aoms.2010.13500]

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