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Abstract:   (557 Views)
Hypertension is known as risk factor of chronic renal disease with higher prevalence in men . As a pilot study, the effect of angiotensin (Ang) 1-7 receptor (MasR) antagonist; A779 on renal function in male and female of two kidneys - one clip (2K1C) hypertensive rats was investigated. The animals’ systolic blood pressure was 152±2.3 mmHg. No significant difference was detected in normalized RPP between male and female rats during saline or A779 administration. The significant reduction of urine flow (UF) and creatinine clearance (CrCL) were detected by A779 infusion in male and female rats when compare vehicle treated rats.  The study indicated that female has more UF and CrCL than male, and A779 attenuate CrCL and UF and abolish sex difference in hypertensive rats.
     
Types of Manuscript: Letter to the editor | Subject: Renal Physiology/Pharmacology

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References
1. Hilliard LM, Sampson AK, Brown RD, Denton KM. The "his and hers" of the renin-angiotensin system. Curr Hypertens Rep 2013; 15: 71-9. [DOI:10.1007/s11906-012-0319-y]
2. Lee SH, Lee YH, Jung SW, Kim DJ, Park SH, Song SJ, et al. Sex-related differences in the intratubular renin-angiotensin system in two-kidney, one-clip hypertensive rats. Am J Physiol Renal Physiol 2019; 317: F670-82. [DOI:10.1152/ajprenal.00451.2018]
3. Patel SN, Ali Q, Samuel P, Steckelings UM, Hussain T. Angiotensin II type 2 receptor and receptor mas are colocalized and functionally interdependent in obese zucker rat kidney. Hypertension 2017; 70: 831-8. [DOI:10.1161/HYPERTENSIONAHA.117.09679]
4. Safari T, Nematbakhsh M, Hilliard LM, Evans RG, Denton KM. Sex differences in the renal vascular response to angiotensin II involves the Mas receptor. Acta Physiol (Oxf) 2012; 206: 150-6. [DOI:10.1111/j.1748-1716.2012.02468.x]
5. Sampson AK, Moritz KM, Denton KM. Postnatal ontogeny of angiotensin receptors and ACE2 in male and female rats. Gend Med 2012; 9: 21-32. [DOI:10.1016/j.genm.2011.12.003]
6. Sullivan JC, Gillis EE. Sex and gender differences in hypertensive kidney injury. Am J Physiol Renal Physiol 2017; 313: 1009-17. [DOI:10.1152/ajprenal.00206.2017]
7. Yim HE, Yoo KH. Renin-angiotensin system - considerations for hypertension and kidney. Electrolyte Blood Press 2008; 6: 42-50. [DOI:10.5049/EBP.2008.6.1.42]

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