Volume 26, Issue 4 (December 2022)                   Physiol Pharmacol 2022, 26(4): 345-362 | Back to browse issues page

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-Ferdous M R, Song Y. Pharmacological potential of ferulic acid for the treatment of metabolic syndrome and its mechanism of action: Review. Physiol Pharmacol 2022; 26 (4) :345-362
URL: http://ppj.phypha.ir/article-1-1799-en.html
Abstract:   (1509 Views)
Recently, obesity causes vital mortality around the globe. Last decade, obesity-related diseases increased significantly worldwide. Even though, effective drugs are not available to treat metabolic diseases such as cardiovascular diseases, Parkinson’s, obesity, and hypertension. Emergence and identifying new drug moieties to treat such metabolic diseases became imperative. Nature is a vital source of remedies and isolates new effective and nontoxic drug candidates. Ferulic acid is a significant phenolic compound that is abundant in various fruits, rice oil, and vegetables. This study highlighted the beneficial effects of ferulic acid for the treatment of metabolic syndrome or obesity. Similarly, in this study, we have highlighted the therapeutic purpose of ferulic acid in treating metabolic syndrome, its mechanism of action as well as its potential pharmacological effect using animal models. Further investigations are needed to demonstrate the significant mechanism of action in clinical trials using the human species.
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Types of Manuscript: Review | Subject: Pharmacokinetics/Dynamics

1. Adam A, Crespy V, Levrat-Verny M-A, Leenhardt F, Leuillet M, Demigné C, et al. The Bioavailability of Ferulic Acid Is Governed Primarily by the Food Matrix Rather than Its Metabolism in Intestine and Liver in Rats. The Journal of Nutrition 2002; 132: 1962-1968. [DOI:10.1093/jn/132.7.1962]
2. Anderson J L, Morrow D A. Acute Myocardial Infarction. N Engl J Med 2017; 376: 2053-2064. [DOI:10.1056/NEJMra1606915]
3. Anis E, Zafeer M F, Firdaus F, Islam S N, Anees Khan A, Ali A, et al. Ferulic acid reinstates mitochondrial dynamics through PGC1alpha expression modulation in 6-hydroxydopamine lesioned rats. Phytother Res 2019. [DOI:10.1002/ptr.6523]
4. Ardiansyah, Ohsaki Y, Shirakawa H, Koseki T, Komai M. Novel effects of a single administration of ferulic acid on the regulation of blood pressure and the hepatic lipid metabolic profile in stroke-prone spontaneously hypertensive rats. J Agric Food Chem 2008; 56: 2825-30. [DOI:10.1021/jf072896y]
5. Aydin S, Aksoy A, Aydin S, Kalayci M, Yilmaz M, Kuloglu T, et al. Today's and yesterday's of pathophysiology: biochemistry of metabolic syndrome and animal models. Nutrition 2014; 30: 1-9. [DOI:10.1016/j.nut.2013.05.013]
6. Balasubashini M S, Rukkumani R, Viswanathan P, Menon V P. Ferulic acid alleviates lipid peroxidation in diabetic rats. Phytother Res 2004; 18: 310-4. [DOI:10.1002/ptr.1440]
7. Bao Y, Chen Q, Xie Y, Tao Z, Jin K, Chen S, et al. Ferulic acid attenuates oxidative DNA damage and inflammatory responses in microglia induced by benzo(a)pyrene. Int Immunopharmacol 2019: 105980. [DOI:10.1016/j.intimp.2019.105980]
8. Bourne L, Paganga G, Baxter D, Hughes P, Rice-Evans C. Absorption of ferulic acid from low-alcohol beer. Free Radic Res 2000; 32: 273-80. [DOI:10.1080/10715760000300281]
9. Chaudhary A, Jaswal V S, Choudhary S, Sharma A, Beniwal V, Tuli H S, et al. Ferulic Acid: A Promising Therapeutic phytochemical and recent patents advances. Recent Pat Inflamm Allergy Drug Discov 2019. [DOI:10.2174/1872213X13666190621125048]
10. Chiang H M, Chen H C, Lin T J, Shih I C, Wen K C. Michelia alba extract attenuates UVB-induced expression of matrix metalloproteinases via MAP kinase pathway in human dermal fibroblasts. Food Chem Toxicol 2012; 50: 4260-9. [DOI:10.1016/j.fct.2012.08.018]
11. Cui L, Zhang Y, Cao H, Wang Y, Teng T, Ma G, et al. Ferulic acid inhibits the transition of amyloid-beta42 monomers to oligomers but accelerates the transition from oligomers to fibrils. J Alzheimers Dis 2013; 37: 19-28. [DOI:10.3233/JAD-130164]
12. Das U, Manna K, Adhikary A, Mishra S, Saha K D, Sharma R D, et al. Ferulic acid enhances the radiation sensitivity of lung and liver carcinoma cells by collapsing redox homeostasis: mechanistic involvement of Akt/p38 MAPK signalling pathway. Free Radic Res 2019; 53: 944-967. [DOI:10.1080/10715762.2019.1655559]
13. Das U, Manna K, Sinha M, Datta S, Das D K, Chakraborty A, et al. Role of ferulic acid in the amelioration of ionizing radiation induced inflammation: a murine model. PLoS One 2014; 9: e97599. [DOI:10.1371/journal.pone.0097599]
14. de Melo T S, Lima P R, Carvalho K M, Fontenele T M, Solon F R, Tome A R, et al. Ferulic acid lowers body weight and visceral fat accumulation via modulation of enzymatic, hormonal and inflammatory changes in a mouse model of high-fat diet-induced obesity. Braz J Med Biol Res 2017; 50: e5630. [DOI:10.1590/1414-431x20165630]
15. DeFronzo R A, Tripathy D. Skeletal muscle insulin resistance is the primary defect in type 2 diabetes. Diabetes Care 2009; 32 Suppl 2: S157-63. [DOI:10.2337/dc09-S302]
16. El-Ashmawy N E, Khedr N F, El-Bahrawy H A, Helal S A. Upregulation of PPAR-gamma mediates the renoprotective effect of omega-3 PUFA and ferulic acid in gentamicin-intoxicated rats. Biomed Pharmacother 2018; 99: 504-510. [DOI:10.1016/j.biopha.2018.01.036]
17. Enriori P J, Evans A E, Sinnayah P, Cowley M A. Leptin resistance and obesity. Obesity (Silver Spring) 2006; 14 Suppl 5: 254s-258s. [DOI:10.1038/oby.2006.319]
18. Erbil G, Sacik U, Yilmaz F, Kisaoglu H, Erbayraktar Z, Pekcetin C, et al. The effect of ferulic acid on experimental traumatic brain damage in rats. Bratisl Lek Listy 2019; 120: 372-379. [DOI:10.4149/BLL_2019_061]
19. Fadel A, Mahmoud A M, Ashworth J J, Li W, Ng Y L, Plunkett A. Health-related effects and improving extractability of cereal arabinoxylans. Int J Biol Macromol 2018; 109: 819-831. [DOI:10.1016/j.ijbiomac.2017.11.055]
20. Fan H, Li X, Zheng L, Chen X, Lan Q, Wu H, et al. Abdominal obesity is strongly associated with Cardiovascular Disease and its Risk Factors in Elderly and very Elderly Community-dwelling Chinese. Sci Rep 2016; 6: 21521. [DOI:10.1038/srep21521]
21. Ghosh S, Basak P, Dutta S, Chowdhury S, Sil P C. New insights into the ameliorative effects of ferulic acid in pathophysiological conditions. Food Chem Toxicol 2017; 103: 41-55. [DOI:10.1016/j.fct.2017.02.028]
22. Gogoi B, Chatterjee P, Mukherjee S, Buragohain A K, Bhattacharya S, Dasgupta S. A polyphenol rescues lipid induced insulin resistance in skeletal muscle cells and adipocytes. Biochem Biophys Res Commun 2014; 452: 382-8. [DOI:10.1016/j.bbrc.2014.08.079]
23. Hamaguchi T, Ono K, Murase A, Yamada M. Phenolic compounds prevent Alzheimer's pathology through different effects on the amyloid-beta aggregation pathway. Am J Pathol 2009; 175: 2557-65. [DOI:10.2353/ajpath.2009.090417]
24. Hernandez-Gea V, Friedman S L. Pathogenesis of liver fibrosis. Annu Rev Pathol 2011; 6: 425-56. [DOI:10.1146/annurev-pathol-011110-130246]
25. Jain P G, Mahajan U B, Shinde S D, Surana S J. Cardioprotective role of FA against isoproterenol induced cardiac toxicity. Mol Biol Rep 2018; 45: 1357-1365. [DOI:10.1007/s11033-018-4297-2]
26. Jin Son M, C W R, Hyun Nam S, Young Kang M. Influence of oryzanol and ferulic Acid on the lipid metabolism and antioxidative status in high fat-fed mice. J Clin Biochem Nutr 2010; 46: 150-6. [DOI:10.3164/jcbn.09-98]
27. Jung U J, Choi M S. Obesity and its metabolic complications: the role of adipokines and the relationship between obesity, inflammation, insulin resistance, dyslipidemia and nonalcoholic fatty liver disease. Int J Mol Sci 2014; 15: 6184-223. [DOI:10.3390/ijms15046184]
28. Kahn S E, Hull R L, Utzschneider K M. Mechanisms linking obesity to insulin resistance and type 2 diabetes. Nature 2006; 444: 840-6. [DOI:10.1038/nature05482]
29. Kamei T, Asano K, Nakamura S. Determination of serum glutamate oxaloacetate transaminase and glutamate pyruvate transaminase by using L-glutamate oxidase. Chem Pharm Bull (Tokyo) 1986; 34: 409-12. [DOI:10.1248/cpb.34.409]
30. Kelainy E G, Ibrahim Laila I M, Ibrahim S R. The effect of ferulic acid against lead-induced oxidative stress and DNA damage in kidney and testes of rats. Environ Sci Pollut Res Int 2019. [DOI:10.1007/s11356-019-06099-6]
31. Kim E O, Min K J, Kwon T K, Um B H, Moreau R A, Choi S W. Anti-inflammatory activity of hydroxycinnamic acid derivatives isolated from corn bran in lipopolysaccharide-stimulated Raw 264.7 macrophages. Food Chem Toxicol 2012; 50: 1309-16. [DOI:10.1016/j.fct.2012.02.011]
32. Kim H S, Cho J Y, Kim D H, Yan J J, Lee H K, Suh H W, et al. Inhibitory effects of long-term administration of ferulic acid on microglial activation induced by intracerebroventricular injection of beta-amyloid peptide (1-42) in mice. Biol Pharm Bull 2004; 27: 120-1. [DOI:10.1248/bpb.27.120]
33. Kim J, Lee C W, Kim E K, Lee S J, Park N H, Kim H S, et al. Inhibition effect of Gynura procumbens extract on UV-B-induced matrix-metalloproteinase expression in human dermal fibroblasts. J Ethnopharmacol 2011; 137: 427-33. [DOI:10.1016/j.jep.2011.04.072]
34. Klop B, Elte J W, Cabezas M C. Dyslipidemia in obesity: mechanisms and potential targets. Nutrients 2013; 5: 1218-40. [DOI:10.3390/nu5041218]
35. Knauf C, Rieusset J, Foretz M, Cani P D, Uldry M, Hosokawa M, et al. Peroxisome proliferator-activated receptor-alpha-null mice have increased white adipose tissue glucose utilization, GLUT4, and fat mass: Role in liver and brain. Endocrinology 2006; 147: 4067-78. [DOI:10.1210/en.2005-1536]
36. Li T, Ferns K, Yan Z Q, Yin S Y, Kou J J, Li D, et al. Acanthopanax senticosus: Photochemistry and Anticancer Potential. American Journal of Chinese Medicine 2016; 44: 1543-1558. [DOI:10.1142/S0192415X16500865]
37. Li X, Wang Y, Wang H, Huang C, Huang Y, Li J. Endoplasmic reticulum stress is the crossroads of autophagy, inflammation, and apoptosis signaling pathways and participates in liver fibrosis. Inflamm Res 2015; 64: 1-7. [DOI:10.1007/s00011-014-0772-y]
38. Lim K H, Ko D, Kim J H. Cardioprotective potential of Korean Red Ginseng extract on isoproterenol-induced cardiac injury in rats. J Ginseng Res 2013; 37: 273-82. [DOI:10.5142/jgr.2013.37.273]
39. Loos R J, Lindgren C M, Li S, Wheeler E, Zhao J H, Prokopenko I, et al. Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet 2008; 40: 768-75. [DOI:10.1038/ng.140]
40. Mahmoud A M, Hussein O E, Abd El-Twab S M, Hozayen W G. Ferulic acid protects against methotrexate nephrotoxicity via activation of Nrf2/ARE/HO-1 signaling and PPARgamma, and suppression of NF-kappaB/NLRP3 inflammasome axis. Food Funct 2019; 10: 4593-4607. [DOI:10.1039/C9FO00114J]
41. Manach C, Scalbert A, Morand C, Remesy C, Jimenez L. Polyphenols: food sources and bioavailability. Am J Clin Nutr 2004; 79: 727-47. [DOI:10.1093/ajcn/79.5.727]
42. Mancuso C, Santangelo R. Ferulic acid: pharmacological and toxicological aspects. Food Chem Toxicol 2014; 65: 185-95. [DOI:10.1016/j.fct.2013.12.024]
43. Mezzetti A, Cipollone F, Cuccurullo F. Oxidative stress and cardiovascular complications in diabetes: isoprostanes as new markers on an old paradigm. Cardiovasc Res 2000; 47: 475-88. [DOI:10.1016/S0008-6363(00)00118-8]
44. Mir S M, Ravuri H G, Pradhan R K, Narra S, Kumar J M, Kuncha M, et al. Ferulic acid protects lipopolysaccharide-induced acute kidney injury by suppressing inflammatory events and upregulating antioxidant defenses in Balb/c mice. Biomed Pharmacother 2018; 100: 304-315. [DOI:10.1016/j.biopha.2018.01.169]
45. Mu M, Zuo S, Wu R M, Deng K S, Lu S, Zhu J J, et al. Ferulic acid attenuates liver fibrosis and hepatic stellate cell activation via inhibition of TGF-beta/Smad signaling pathway. Drug Des Devel Ther 2018; 12: 4107-4115. [DOI:10.2147/DDDT.S186726]
46. Mu M, Zuo S, Wu R M, Deng K S, Lu S, Zhu J J, et al. Ferulic acid attenuates liver fibrosis and hepatic stellate cell activation via inhibition of TGF-beta/Smad signaling pathway [Corrigendum]. Drug Des Devel Ther 2019; 13: 1819. [DOI:10.2147/DDDT.S215949]
47. Nagoor Meeran M F, Jagadeesh G S, Selvaraj P. Thymol attenuates inflammation in isoproterenol induced myocardial infarcted rats by inhibiting the release of lysosomal enzymes and downregulating the expressions of proinflammatory cytokines. Eur J Pharmacol 2015; 754: 153-61. [DOI:10.1016/j.ejphar.2015.02.028]
48. Naowaboot J, Piyabhan P, Munkong N, Parklak W, Pannangpetch P. Ferulic acid improves lipid and glucose homeostasis in high-fat diet-induced obese mice. Clin Exp Pharmacol Physiol 2016; 43: 242-50. [DOI:10.1111/1440-1681.12514]
49. Narasimhan A, Chinnaiyan M, Karundevi B. Ferulic acid exerts its antidiabetic effect by modulating insulin-signalling molecules in the liver of high-fat diet and fructose-induced type-2 diabetic adult male rat. Appl Physiol Nutr Metab 2015a; 40: 769-81. [DOI:10.1139/apnm-2015-0002]
50. Narasimhan A, Chinnaiyan M, Karundevi B. Ferulic acid regulates hepatic GLUT2 gene expression in high fat and fructose-induced type-2 diabetic adult male rat. Eur J Pharmacol 2015b; 761: 391-7. [DOI:10.1016/j.ejphar.2015.04.043]
51. Nascimento A R, Machado M, de Jesus N, Gomes F, Lessa M A, Bonomo I T, et al. Structural and functional microvascular alterations in a rat model of metabolic syndrome induced by a high-fat diet. Obesity (Silver Spring) 2013; 21: 2046-54. [DOI:10.1002/oby.20358]
52. Niu C, Sheng Y, Zhu E, Ji L, Wang Z. Ferulic acid prevents liver injury induced by Diosbulbin B and its mechanism. Biosci Trends 2016; 10: 386-391. [DOI:10.5582/bst.2016.01152]
53. Okuda M, Fujita Y, Sugimoto H. The Additive Effects of Low Dose Intake of Ferulic Acid, Phosphatidylserine and Curcumin, Not Alone, Improve Cognitive Function in APPswe/PS1dE9 Transgenic Mice. Biol Pharm Bull 2019; 42: 1694-1706. [DOI:10.1248/bpb.b19-00332]
54. Ono K, Hirohata M, Yamada M. Ferulic acid destabilizes preformed beta-amyloid fibrils in vitro. Biochem Biophys Res Commun 2005; 336: 444-9. [DOI:10.1016/j.bbrc.2005.08.148]
55. Ou L, Kong L Y, Zhang X M, Niwa M. Oxidation of ferulic acid by Momordica charantia peroxidase and related anti-inflammation activity changes. Biol Pharm Bull 2003; 26: 1511-6. [DOI:10.1248/bpb.26.1511]
56. Panchal S K, Brown L. Rodent models for metabolic syndrome research. J Biomed Biotechnol 2011; 2011: 351982. [DOI:10.1155/2011/351982]
57. Panchal S K, Poudyal H, Iyer A, Nazer R, Alam M A, Diwan V, et al. High-carbohydrate, high-fat diet-induced metabolic syndrome and cardiovascular remodeling in rats. J Cardiovasc Pharmacol 2011; 57: 611-24. [DOI:10.1097/FJC.0b013e3181feb90a]
58. Park H J, Cho J H, Hong S H, Kim D H, Jung H Y, Kang I K, et al. Whitening and anti-wrinkle activities of ferulic acid isolated from Tetragonia tetragonioides in B16F10 melanoma and CCD-986sk fibroblast cells. J Nat Med 2018; 72: 127-135. [DOI:10.1007/s11418-017-1120-7]
59. Park H J, Ock S M, Kim H J, Park H J, Lee Y B, Choi J M, et al. Vitamin C attenuates ERK signalling to inhibit the regulation of collagen production by LL-37 in human dermal fibroblasts. Exp Dermatol 2010; 19: e258-64. [DOI:10.1111/j.1600-0625.2010.01070.x]
60. Patsouris D, Reddy J K, Muller M, Kersten S. Peroxisome proliferator-activated receptor alpha mediates the effects of high-fat diet on hepatic gene expression. Endocrinology 2006; 147: 1508-16. [DOI:10.1210/en.2005-1132]
61. Perez-Ternero C, Werner C M, Nickel A G, Herrera M D, Motilva M J, Bohm M, et al. Ferulic acid, a bioactive component of rice bran, improves oxidative stress and mitochondrial biogenesis and dynamics in mice and in human mononuclear cells. J Nutr Biochem 2017; 48: 51-61. [DOI:10.1016/j.jnutbio.2017.06.011]
62. Prakash D, Upadhyay G, Pushpangadan P, Gupta C. Antioxidant and free radical scavenging activities of some fruits. J Complement Integr Med 2011; 8. [DOI:10.2202/1553-3840.1513]
63. Reddy J K, Rao M S. Lipid metabolism and liver inflammation. II. Fatty liver disease and fatty acid oxidation. Am J Physiol Gastrointest Liver Physiol 2006; 290: G852-8. [DOI:10.1152/ajpgi.00521.2005]
64. Rondini L, Peyrat-Maillard M N, Marsset-Baglieri A, Berset C. Sulfated ferulic acid is the main in vivo metabolite found after short-term ingestion of free ferulic acid in rats. J Agric Food Chem 2002; 50: 3037-41. [DOI:10.1021/jf011295i]
65. Rondini L, Peyrat-Maillard M N, Marsset-Baglieri A, Fromentin G, Durand P, Tomé D, et al. Bound ferulic acid from bran is more bioavailable than the free compound in rat. J Agric Food Chem 2004; 52: 4338-43. [DOI:10.1021/jf0348323]
66. Salazar-López N, Astiazarán-García H, González-Aguilar G, Loarca-Piña G, Ezquerra-Brauer J-M, Domínguez Avila J, et al. Ferulic Acid on Glucose Dysregulation, Dyslipidemia, and Inflammation in Diet-Induced Obese Rats: An Integrated Study. Nutrients 2017; 9: 675. [DOI:10.3390/nu9070675]
67. Sasaki K, Iwata N, Ferdousi F, Isoda H. Antidepressant‐Like Effect of Ferulic Acid via Promotion of Energy Metabolism Activity. Molecular Nutrition & Food Research 2019; 63: 1900327. [DOI:10.1002/mnfr.201900327]
68. Senaphan K, Kukongviriyapan U, Sangartit W, Pakdeechote P, Pannangpetch P, Prachaney P, et al. Ferulic Acid Alleviates Changes in a Rat Model of Metabolic Syndrome Induced by High-Carbohydrate, High-Fat Diet. Nutrients 2015; 7: 6446-64. [DOI:10.3390/nu7085283]
69. Seo J H, Chae Y C, Kossenkov A V, Lee Y G, Tang H Y, Agarwal E, et al. MFF Regulation of Mitochondrial Cell Death Is a Therapeutic Target in Cancer. Cancer Res 2019; 79: 6215-6226. [DOI:10.1158/0008-5472.CAN-19-1982]
70. Sgarbossa A, Giacomazza D, di Carlo M. Ferulic Acid: A Hope for Alzheimer's Disease Therapy from Plants. Nutrients 2015; 7: 5764-82. [DOI:10.3390/nu7075246]
71. Sohn J W, Elmquist J K, Williams K W. Neuronal circuits that regulate feeding behavior and metabolism. Trends Neurosci 2013; 36: 504-12. [DOI:10.1016/j.tins.2013.05.003]
72. Sri Balasubashini M, Rukkumani R, Menon V P. Protective effects of ferulic acid on hyperlipidemic diabetic rats. Acta Diabetol 2003; 40: 118-22. [DOI:10.1007/s00592-003-0099-6]
73. Srinivasan M, Sudheer A R, Menon V P. Ferulic Acid: therapeutic potential through its antioxidant property. J Clin Biochem Nutr 2007; 40: 92-100. [DOI:10.3164/jcbn.40.92]
74. Sultana R, Ravagna A, Mohmmad-Abdul H, Calabrese V, Butterfield D A. Ferulic acid ethyl ester protects neurons against amyloid beta- peptide(1-42)-induced oxidative stress and neurotoxicity: relationship to antioxidant activity. J Neurochem 2005; 92: 749-58. [DOI:10.1111/j.1471-4159.2004.02899.x]
75. Suzuki A, Yamamoto M, Jokura H, Fujii A, Tokimitsu I, Hase T, et al. Ferulic acid restores endothelium-dependent vasodilation in aortas of spontaneously hypertensive rats. Am J Hypertens 2007; 20: 508-13. [DOI:10.1016/j.amjhyper.2006.11.008]
76. Tailleux A, Wouters K, Staels B. Roles of PPARs in NAFLD: potential therapeutic targets. Biochim Biophys Acta 2012; 1821: 809-18. [DOI:10.1016/j.bbalip.2011.10.016]
77. Tsao R. Chemistry and biochemistry of dietary polyphenols. Nutrients 2010; 2: 1231-46. [DOI:10.3390/nu2121231]
78. Velloso L A, Araujo E P, de Souza C T. Diet-induced inflammation of the hypothalamus in obesity. Neuroimmunomodulation 2008; 15: 189-93. [DOI:10.1159/000153423]
79. Wang J M, Sheng Y C, Ji L L, Wang Z T. Ferulic acid prevents liver injury and increases the anti-tumor effect of diosbulbin B in vivo. J Zhejiang Univ Sci B 2014; 15: 540-7. [DOI:10.1631/jzus.B1300250]
80. Williamson G, Manach C. Bioavailability and bioefficacy of polyphenols in humans. II. Review of 93 intervention studies. Am J Clin Nutr 2005; 81: 243s-255s. [DOI:10.1093/ajcn/81.1.243S]
81. Xu Y, Zhang M, Wu T, Dai S, Xu J, Zhou Z. The anti-obesity effect of green tea polysaccharides, polyphenols and caffeine in rats fed with a high-fat diet. Food Funct 2015; 6: 297-304. [DOI:10.1039/C4FO00970C]
82. Yan J J, Cho J Y, Kim H S, Kim K L, Jung J S, Huh S O, et al. Protection against beta-amyloid peptide toxicity in vivo with long-term administration of ferulic acid. Br J Pharmacol 2001; 133: 89-96. [DOI:10.1038/sj.bjp.0704047]
83. Yao Q, Lin Y, Li X, Shen X, Wang J, Tu C. Curcumin ameliorates intrahepatic angiogenesis and capillarization of the sinusoids in carbon tetrachloride-induced rat liver fibrosis. Toxicol Lett 2013; 222: 72-82. [DOI:10.1016/j.toxlet.2013.06.240]
84. Yin C L, Lu R G, Zhu J F, Huang H M, Liu X, Li Q F, et al. The study of neuroprotective effect of ferulic acid based on cell metabolomics. Eur J Pharmacol 2019; 864: 172694. [DOI:10.1016/j.ejphar.2019.172694]
85. Yuan J, Ge K, Mu J, Rong J, Zhang L, Wang B, et al. Ferulic acid attenuated acetaminophen-induced hepatotoxicity though down-regulating the cytochrome P 2E1 and inhibiting toll-like receptor 4 signaling-mediated inflammation in mice. Am J Transl Res 2016; 8: 4205-4214.
86. Zhao Z, Egashira Y, Sanada H. Ferulic acid sugar esters are recovered in rat plasma and urine mainly as the sulfoglucuronide of ferulic acid. J Nutr 2003; 133: 1355-61. [DOI:10.1093/jn/133.5.1355]
87. Zhao Z, Moghadasian M H. Chemistry, natural sources, dietary intake and pharmacokinetic properties of ferulic acid: A review. Food Chem 2008; 109: 691-702. [DOI:10.1016/j.foodchem.2008.02.039]
88. Zhou B, Kreuzer J, Kumsta C, Wu L, Kamer K J, Cedillo L, et al. Mitochondrial Permeability Uncouples Elevated Autophagy and Lifespan Extension. Cell 2019; 177: 299-314 e16. [DOI:10.1016/j.cell.2019.02.013]

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