Volume 10, Issue 3 (Fall 2006)
Physiol Pharmacol 2006, 10(3): 259-265 |
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haghighi N, Kessmati M, fathi Moghadam2 H. Study of interaction between opioid and ?-2 adrenergic systems in analgesic effect of oxytocin in locus coeruleus nucleus . Physiol Pharmacol 2006; 10 (3) :259-265
URL: http://ppj.phypha.ir/article-1-281-en.html
URL: http://ppj.phypha.ir/article-1-281-en.html
Abstract: (17706 Views)
Introduction: Oxytocin is a active neuropeptide of central nervous system. In this study
the effects of naloxone (opioid receptor antagonist) and yohimbine (α-2 adrenergic receptor
antagonist) on analgesic effect of oxytocin applied into the locus coeruleus (LC) nucleus
were investigated.
Methods: Adult male Wistar rats were used. Animals divided into different groups
receiving saline, oxytocin (3 nmol / 2μl), naloxone (3 nmol / 2μl) + oxytocin, yohimbine (3
nmol / 2μl) + oxytocin, and naloxone + yohimbine + oxytocin. Hot-plate and tail-flick tests
were used to evaluate pain threshold.
Results: Data showed that the injection of oxytocin into the LC nucleus increases the
response time to thermal stimulations in both tail flick and hot plate tests. Injection of
naloxone and yohimbine either separately and or in combination inhibite the antinociception
effect of oxytocin.
Conclusion: It seems that oxytocin induces its inhibitory effect on acute pain via LC
nucleus. This effect is probably mediated by the combination of opioid and α-2 adrenergic
systems.
Type of Manuscript: Experimental research article |
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