en Clinical Physiology/Pharmacology Clinical Physiology/Pharmacology Review Review <p><span style="font-size:12px;"><span style="font-family:Arial;"><span style="line-height:200%"><span style="background:white"><span style="line-height:200%"><span new="" roman="" times=""><span style="color:#161719">As society ages, spinal surgery demand increases due to advancements in surgical techniques and safer anesthesia. Approximately 10 to 20% of patients undergoing spinal surgery may experience complications. Rare complications include cerebrovascular accidents (CVA). In this review, we aim to investigate remote cerebrovascular accidents after spinal surgery.</span></span></span></span> <span style="background:white"><span style="line-height:200%"><span new="" roman="" times=""><span style="color:#161719">The study was conducted according to PRISMA guidelines and registered with PROSPERO (</span><span style="color:black">CRD42023425418)</span><span style="color:#161719">. PubMed/Medline, Embase, Scopus, GoogleScholar were searched until 4 March 2024. Twenty cohort studies comprising 612,135 patients were included, among whom 3990 cerebrovascular events were reported. The pooled incidence of CVA with a pooled event rate of 0.002 </span><span style="color:black">(95% CI: 0.001&ndash;0.003). </span><span style="color:#161719">with substantial heterogeneity (I²=66.97%). This overall estimate combines studies with different follow-up periods and does not represent the risk of CVA over any specific time interval.</span></span></span></span> <span style="background:white"><span style="line-height:200%"><span new="" roman="" times=""><span style="color:#161719">The meta-regression analysis showed the insignificant role of </span><span style="color:black">gender (p-value: 0.966), age (p-value: 0. 1256), diabetes (p-value: 0.8701) and previous cardiovascular disease (p-value: 0.5064) in the incidence of spinal surgery-induced CVA.</span><span style="color:#161719"> This systematic review shows that cerebrovascular events after spine surgery are uncommon but not negligible and that their reported frequency depends strongly on the duration of outcome ascertain. Besides, none of the factors used for meta-regression predict the incidence of remote vascular complications. </span></span></span></span></span><br /> &nbsp;</span></span></p> Cerebrovascular Accident,Spine Surgery,Complication,Meta-Analysis,Meta-regression 0 0 http://ppj.phypha.ir/browse.php?a_code=A-10-1299-6&slc_lang=en&sid=1 Mohammadreza Shahmohammadi mr_shahmohammadi@sbmu.ac.ir 3200319475328460039741 3200319475328460039741 No Functional Neurosurgery Research Center, Research Institute of Functional Neurosurgery, Shohada Tajrish Neurosurgical Center of Excellence, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Narges Bazgir drnargesbazgir1996@gmail.com 3200319475328460039742 3200319475328460039742 No Functional Neurosurgery Research Center, Research Institute of Functional Neurosurgery, Shohada Tajrish Neurosurgical Center of Excellence, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Mohammad Amin Habibi mohammad.habibi1392@yahoo.com 3200319475328460039743 3200319475328460039743 No Skull Base Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran Setareh Akbari strha632@gmail.com 3200319475328460039744 3200319475328460039744 No Functional Neurosurgery Research Center, Research Institute of Functional Neurosurgery, Shohada Tajrish Neurosurgical Center of Excellence, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Mehdi Farokhi Mehfar2563@gmail.com 3200319475328460039745 3200319475328460039745 No 1. Functional Neurosurgery Research Center, Research Institute of Functional Neurosurgery, Shohada Tajrish Neurosurgical Center of Excellence, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Alireza Zali dr_alirezazali@yahoo.com 3200319475328460039746 3200319475328460039746 No 1. Functional Neurosurgery Research Center, Research Institute of Functional Neurosurgery, Shohada Tajrish Neurosurgical Center of Excellence, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Miilad Rahimzadegan Milad.Rahimzadegan@gmail.com 3200319475328460039747 3200319475328460039747 No Functional Neurosurgery Research Center, Research Institute of Functional Neurosurgery, Shohada Tajrish Neurosurgical Center of Excellence, Shahid Beheshti University of Medical Sciences, Tehran, Iran Somayeh Niknazar niknazar@sbmu.ac.ir 3200319475328460039748 3200319475328460039748 Yes Functional Neurosurgery Research Center, Research Institute of Functional Neurosurgery, Shohada Tajrish Neurosurgical Center of Excellence, Shahid Beheshti University of Medical Sciences, Tehran, Iran.