Volume 18, Issue 2 ( Summer 2014)                   Physiol Pharmacol 2014, 18(2): 215-223 | Back to browse issues page

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Khakpay R, Barani S, Hatami Nemati H. The antinociceptive effect of 17β-estradiol in the paragigantocellularis lateralis of male rats is mediated by estrogenic receptors. Physiol Pharmacol 2014; 18 (2) :215-223
URL: http://ppj.phypha.ir/article-1-1007-en.html
Abstract:   (8308 Views)
Introduction: 17β-Estradiol is a neuroactive steroid and its pain modulatory role has been well studied previously. 17β-Estradiol modulates nociception by binding to its receptors and also by allosteric interaction with other membrane - bound receptors such as glutamate and GABAA receptors. Paragigantocellularis lateralis (LPGi) is also involved in pain modulation and perception, in addition to its well-known autonomic functions such as regulation of circulation. Methods: In order to study the effect of intra-LPGi injection of 17β-estradiol on both acute and persistent pain, 50 μl of 4% formalin was injected into the male rats’ hind paw, then fo rmalin-induced paw jerking behaviour was recorded for 60 min. Results: The results of this study indicated that intra-LPGi injection of 17β-estradiol attenuated the second phase, but not the acute phase of formalin induced pain (P< 0.001). The estrogen receptor antagonist (ICI182,780) counteracted 17β-estradiol’s effect, but could not reverse the antinociceptive effect of 17β -estradiol to its basic level. Conclusion: It may be concluded that a part of the analgesic effect of 17β-estradiol in formalin induced inflammatory pain is mediated by intracellular estrogen receptors the other part of this effect is possibly mediated through allosteric interactions with other membrane-bound receptors such as glutamate and GABAA receptors.
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