Epilepsy is accompanied with a strong change in neuronal activity not only in excitatory (glutamatergic) and inhibitory (GABAergic) neurotransmission, but also in neuromodulatory agents. Dopaminergic system, as an important neuromodulatory system of the brain, has significant effect on neuronal excitability. In addition, this system undergoes many changes in epileptic brain. Understanding the effects of dopaminergic system in neuronal activities in epileptic brain and knowing the seizure-induced changes in dopaminergic system can shed light into finding the mechanisms involved in epileptogenesis and can help us in finding new treatments for epilepsy. In this review we briefly introduce dopaminergic system and its changes in brain areas which have role in epilepsy. Then, we will focus on the evidences showing the relationship between epilepsy and dopaminergic system.