XML Print


Abstract:   (146 Views)
Introduction: The aim was the effect of vitamin D on glycemic control and biochemical indices in type 2 diabetes.
 
Methods: This randomized double blind placebo-controlled clinical trial was conducted on 80 patients with T2DM referred to Shahid Beheshti hospital. These patients were randomly classified into case and control groups. Case group consumed 50,000 IU of vitamin D once a week for 12 weeks and control group placebo. Biochemical and lipid parameters and vit D3 were measured in two groups. Glycosylated hemoglobin (HbA1c) was assessed by latex enhance immunoturbidimetric assay.
Results
There was no significant difference between case and control groups in terms of age, sex, BMI and used medications (p>0.05). The mean vitamin D level in case and control groups before intervention was 15.06 ±3.307 and 15.83± 2.509 ng/ml (p= 0.24) and after intervention was 49.77 ±15.73 and 14.91±3.13 ng/ml respectively (p<0.01). The mean FBS in case and control groups after intervention was 156.565±32.23 and 147.75±35.06 mg/dl (p=0.245), respectively. The mean HbA1c in case and control groups before intervention was 7.59± 0.39 % and 7.66± 0.38 % (p=0.46) and after intervention was 7.26 ± 0.60 and 7.60 ± 0.38, respectively (p=0.002). Moreover, significant difference was seen between case (20.2± 5.74 IU/L) and control groups (23.35± 7.80 IU/L) in terms of ALT, after intervention (p=0.03).
Conclusion
According to these findings, vitamin D supplementation possibly through decreasing HbA1C and hepatic ALT could improve diabetes complications.
     
Types of Manuscript: Original Research | Subject: Endocrinology