XML Print


Abstract:   (166 Views)
Introduction: Cisplatin is one of the most widely used drugs for the treatment of various cancers but has oxidative tissue damage as one of its side effects. This study investigated the oxidative stress profile in some important body tissues following the co-administration of Cisplatin (CIS) and Resveratrol (RSV). 
Methods: Thirty-five adult female Sprague–Dawley rats with an average body weight of 162 g were divided into 5 groups (n=7) and used for this experimental study. Group A served as the normal control group and received distilled water only. Group B received only a single dose intraperitoneal injection of 10 mg/kg CIS. Groups C, D, and E were orally given 5, 10, and 20 mg/kg of RSV respectively for 7 days, starting 24 hours after a CIS single dose intraperitoneal injection of 10 mg/kg. Selected body tissues were harvested for oxidative stress profiling at the end of the experiment. 
Results: CIS significantly (p<0.05) increased Malondialdehyde (MDA) levels, and significantly decreased Glutathione (GSH), superoxide dismutase (SOD), and catalase (CAT) levels in all the tissues assessed (ovary, uterus, liver, kidney, pancreas, stomach and spleen) when compared to the normal control. RSV treatment caused the reversal of these effects: MDA levels were significantly decreased, while GSH, SOD, and CAT levels were significantly (p<0.05) increased across all the examined tissues. 
Conclusion: RSV at different doses could be effective in the management of CIS-induced oxidative stress and lipid peroxidation across some body tissues. However, this effect may
be dependent on the dose of CIS and RSV.
     
Types of Manuscript: Original Research | Subject: Pharmacology