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Shahidi S, Rabiee L, Komaki A, Sadeghian R. High-dose fluoxetine improved long-term potentiation of the hippocampal dentate gyrus in male rats. Physiol Pharmacol. 2021;
URL: http://ppj.phypha.ir/article-1-1699-en.html
Abstract:   (51 Views)
Paradoxical data have been reported on the effects of treatment with fluoxetine on different types of learning and memory. Hippocampus-dependent memory is mediated by long-term potentiation (LTP). Here, we evaluated the effects of acute administration of fluoxetine on LTP induction in the hippocampal dentate gyrus (DG) of intact rats.  Eighteen rats were divided into three groups: the control group received saline 15 min before high-frequency stimulation (HFS) and the fluoxetine groups were treated with fluoxetine (2 or 10 mg/kg) 15 min before HFS. The rats were anesthetized with urethane and put in a stereotaxic system for surgery, electrode implantation, and field recording. After ensuring a steady-state baseline response, a single intraperitoneal injection of saline or fluoxetine (2 or 10 mg/kg) was done. Next, population spike (PS) amplitude, excitatory postsynaptic potential (EPSP) slope, and paired-pulse stimuli (to determine recurrent inhibitory interneuron) were measured in the hippocampal DG in three groups. The results showed that PS amplitude markedly increased in the fluoxetine (2 and 10 mg/kg) group than in the saline group. Also, EPSP slope induction in the fluoxetine (10 mg/kg) group showed an increase, 60 min after HFS compared with the control group. Fluoxetine did not significantly affect recurrent inhibition. These results indicated that the acute administration of high-dose fluoxetine (10 mg/kg) can induce LTP. Thus, fluoxetine can be considered as a memory enhancer in intact rats.
Types of Manuscript: Original Research | Subject: Learning and memory

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