Volume 11, Issue 4 (Winter 2008)                   Physiol Pharmacol 2008, 11(4): 293-299 | Back to browse issues page

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Hoseinzadeh M, Pouraboli I, Abbasnejad M, Pouraboli B. Effect of coadministeration of NO and morphine in CA3 of hippocampus on learning and spatial memory in morphine dependent male rats. Physiol Pharmacol. 2008; 11 (4) :293-299
URL: http://ppj.phypha.ir/article-1-239-en.html
Abstract:   (19003 Views)
Abstract: ِIntroduction: The effect of morphine dependency on learning and spatial memory is controversial. So in this study effect of co-administeration of nitric oxide (NO) and morphine in CA3 of hippocampus on learning and spatial memory in morphine dependent rats was investigated. Methods: After anaesthetization of male rats, cannulae implanted bilaterally in CA3 of hippocampus. After recovery period (7 days), morphine dependency induced then animals divided in 6 groups that received 1μl saline (Sham), L-Arginine, L-Name and morphine individually and L-Arginine with morphine or L-Name with morphine individually. Morphine dependency was induced by subcutaneous injection of morphine(10mg/kg first day and 20mg/kg for four days). Last dose of morphine(20mg/kg) was injected daily to maintain morphine dependency during test period (5 days) in morris water maze Results: Results showed that L-Name decreased learning in morphine dependent rats although was ineffective on retention of memory. Morphine did not affect learning and spatial memory. Co-administeration of L-Arginine and morphine not only improved the effect of morphine on learning and memory but also promote the effect of L-Arginine on learning and spatial memory. Conclusion: Thus co-administeration of NO and morphine in morphine dependent rats can improve learning and spatial memory differently from using them individually.
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Types of Manuscript: Original Research | Subject: Pain and addiction