Volume 10, Issue 4 (Winter 2007)                   Physiol Pharmacol 2007, 10(4): 303-311 | Back to browse issues page

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Khori V, Nayebpour M. Effect of Artemisia absinthium on electrophysiological properties of isolated heart of rats . Physiol Pharmacol. 2007; 10 (4) :303-311
URL: http://ppj.phypha.ir/article-1-289-en.html
Abstract:   (15847 Views)
Introduction: Treatment of supraventricular arrhythmia includes wide range of medical interventions. Herbal remedies are suitable alternatives for synthetic drugs due to their availability, minimal side effects and lower price. Pharmacological studies and traditional medical literature point to the cardiovascular effects of the Artemisia absinthium L. from Compositae family of plants. Methods: In the present study we used Langendorff model of isolated heart of rats as an experimental model to determine the effect of various concentrations of methanolic extract of A. absinthium (3×10 -11 %W/V to 4× 10 -8 %W/V) on electrophysiological properties of isolated hearts. Results: Our results showed depressant effect of A. absinthium extract on Wenchebach Cycle Length (WBCL), AV Conduction Time (AVCT), Effective and Functional Refractory Periods (ERP & FRP) of the isolated heart. Conclusion: The results indicated potential antiarrhythmic effect of A. absinthium extract in treating supraventricular tachyarrhythmia.
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