Volume 13, Issue 1 (Spring 2009)                   Physiol Pharmacol 2009, 13(1): 28-36 | Back to browse issues page

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khori V, nayebpour M, mirabbasi A, pourabouk M. Role of slow pathway after nodal fast pathway ablation on the basic and rate- dependent properties of the isolated rabbit atrioventricularNode. Physiol Pharmacol. 2009; 13 (1) :28-36
URL: http://ppj.phypha.ir/article-1-491-en.html
Abstract:   (10519 Views)

  Introduction : The aim of this study is to obtain new insight into possible relation between functional properties of slow concealed pathway and rate-dependent properties of AV-node.

  Methods : Rate-dependent nodal properties of recovery, facilitation, and fatigue were characterized by stimulation protocols in one groups of (N=7) isolated superfused AV-Nodal rabbits. Small miniature lesions were made by delivering constant voltage (110 V-100 s) with unipolar silver electrode.

  Results : Fast pathway ablation significantly decreased facilitation and had no effect on fatigue and nodal refractoriness. The most important effect of fast pathway ablation was prolongation of minimum conduction time.

  Conclusion : The FP-ablation revealed the presence of the concealed SP. Rate-dependent property of node is dependent to dynamic interaction between concealed slow with slow pathway. Fast pathway involved in the mechanism of facilitation.


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