Volume 13, Issue 3 (Fall 2009)
Physiol Pharmacol 2009, 13(3): 297-307 |
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Abdolahnejad A, Gol A, Dabiri S. Garlic effects on reproductive complications of diabetes mellitus in male rats. Physiol Pharmacol 2009; 13 (3) :297-307
URL: http://ppj.phypha.ir/article-1-536-en.html
URL: http://ppj.phypha.ir/article-1-536-en.html
Abstract: (18747 Views)
Introduction: Diabetes mellitus has adverse effects on male sexual and reproductive functions in human and
animals. Diabetes results in reduced fertility and libido. Medicinal plants have attracted much attention in controlling
many diseases such as diabetes. In the present study, we aimed to investigate the effect of garlic juice on testicular
damage.
Methods: Forty male rats (250±20) were divided into 5 groups as follows: 1- Group normal (N) 2- Group
Normal+Garlic (N+G) received garlic juice for 6 weeks. 3- Diabetic (D) received streptozotocin (STZ), 60mg/kg
BW/i.p. 4- Group diabetic+garlic before (D+Gb) received garlic juice for 3 weeks before STZ injection and continued
for more 3 weeks. 5- Group diabetic+garlic after (D+Ga) three days after STZ injection, they received garlic juice for 3
weeks. Garlic juice was given by gavage (1ml/100g BW). Number of leydig cells, testis weight, serum levels of
testosterone and estradiol were assessed.
Results: diabetic rats showed a marked decrease in the number of leydig cells, testis weight, serum levels of
testosterone and estradiol. Garlic juice significantly increased the number of leydig cells, testis weight, serum levels of
testosterone and estradiol in group 4 and 5 compared to group 3. The diabetic group receiving garlic before STZ
injection showed more amelioration in complications than that receiving it after STZ injection.
Conclusion: these results suggest that garlic juice supplementation could play both preventive and therapeutic role
on testicular damage in diabetic rats.
Type of Manuscript: Experimental research article |
Subject:
Endocrine Physiology/Pharmacology
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