Volume 15, Issue 1 (Spring 2011)
Physiol Pharmacol 2011, 15(1): 72-89 |
Back to browse issues page
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Shahraki A. Metabotropic glutamate receptors and their ligands applications in neurological and psychiatric disorders. Physiol Pharmacol 2011; 15 (1) :72-89
URL: http://ppj.phypha.ir/article-1-684-en.html
URL: http://ppj.phypha.ir/article-1-684-en.html
Abstract: (13708 Views)
Metabotropic glutamate receptors (mGluRs) consist of a large family of G-protein coupled receptors that are critical
for regulating normal neuronal function in the central nervous system. The wide distribution and diverse physiological
roles of various mGluR subtypes make them highly attractive targets for the treatment of a number of neurological and
psychiatric disorders. The discovery of subtype selective ligands for these receptors has provided the tools to support a
number of preclinical studies, suggesting the numerous therapeutic potential that lies in the ability selectively to
modulate a specific mGluR subtype. mGluRs do not activate ion channels directly but instead through G-protiens
activate second messenger mechanisms in the neurons. So far 8 subtypes of mGluRs have been identified which divided
into three groups (Group I, II, and III) according to their sequence similarities, Signal transduction mechanisms and
pharmacological properties. Depending on the receptor subtype, they might be localized at presynaptic or postsynaptic
sites which regulate glutamate and other neurotransmitters release.
As I applied many mGluR ligands on hippocampal slices and observed interesting results on synaptic transmission
and modulation of certain neurotransmitters such as adenosine, I intended to study their application in neurological
diseases. The method was based on my experiences from researches and different seminars to evaluate last decade
development on mGluRs and their ligands application in certain neurological disorders. Therefore, aim of this review
article is to describe mGluRs and their role in the excitotoxicity and neuroprotection. Then, application of different
mGluR ligands for the treatment of a variety of neurological disorders including schizophrenia, Parkinson's disease,
anxiety disorders, epilepsy, and drug abuse has been described.
Keywords: Metabotropic glutamatereceptors, excitotoxicity, neuroprotection, neurological disorders, synaptic transmission.
Type of Manuscript: Experimental research article |
Subject:
Pharmacokinetics/Dynamics
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
