Volume 15, Issue 1 (Spring 2011)
Physiol Pharmacol 2011, 15(1): 116-123 |
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Safari F, Hajizadeh S, Shekarforush S, Forouzandeh M, Foadoddini M, Bayat G, et al . Effects of pretreatment with non hypotensive dose of ramiprilat and losartan on myocardial ischemia-reperfusion induced arrhythmias and infarct size in rats. Physiol Pharmacol 2011; 15 (1) :116-123
URL: http://ppj.phypha.ir/article-1-701-en.html
URL: http://ppj.phypha.ir/article-1-701-en.html
Fatemeh Safari 
, Sohrab Hajizadeh , Shahnaz Shekarforush , Mehdi Forouzandeh , Mohsen Foadoddini , Gholamreza Bayat , Bita Houshmand , Ali Khoshbaten
, Sohrab Hajizadeh , Shahnaz Shekarforush , Mehdi Forouzandeh , Mohsen Foadoddini , Gholamreza Bayat , Bita Houshmand , Ali Khoshbaten
Abstract: (15838 Views)
Introduction: Inhibition of renin angiotensin system represents an important approach in the management of
cardiovascular diseases. The aim of this study was to explore the effects of pretreatment with non-hypotensive dose of
angiotensin converting enzyme (ACE) inhibitor, ramiprilat and angiotensin type 1 (AT1) receptor blocker, losartan on
myocardial infarct size and arrhythmias in a rat model of ischemia-reperfusion injury.
Methods: Seventy male Wistar rats were divided into five groups. One group received saline as control. Other
groups were given 10 mg/kg/day of losartan for one (L-1W) or ten weeks (L-10W) as well as 50 μg/kg/day of ramiprilat
for one (R-1W) or ten weeks (R-10W) using a feeding needle. The rats were subjected to 30 minutes occlusion and 120
minutes reperfusion of the left coronary artery. Infarct size was determined using triphenyl tetrazolium chloride
staining. Ischemia-induced ventricular arrhythmias were analyzed in accordance with the Lambeth conventions.
Results: Myocardial infarct size and the number of ventricular beats were significantly reduced in R-1W group, but
the reduction was not significant in L-1W. After increasing the duration of pretreatment to 10 weeks in L-10W group,
the infarct size, the number of ventricular beats and the episodes of ventricular tachycardia were significantly decreased.
However in R-10W group the reduction of ventricular arrhythmias was not significant
Conclusion: Based on the above mentioned results it could be concluded that losartan and ramiprilat, at a nonhypotensive
dose, can reduce the induction of arrhythmias and infarct size following myocardial ischemia reperfusion.
These drugs appear to act in a time-dependent manner. Therefore, we expected an increased cardiac effect by long-term
administration of losartan. However prolonged treatment with ramiprilat reduced its protective effect.
Type of Manuscript: Experimental research article |
Subject:
Cardiovascular Physiology/Pharmacology
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