Volume 18, Issue 1 (Spring 2014)
Physiol Pharmacol 2014, 18(1): 61-71 |
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Bagheri Nikoo G, Khosravi M, Sahraei H, Ranjbaran M, Sarahian N, Zardooz H, et al . Effects of systemic and intra-accumbal memantine administration on the impacts of plantar electrical shock in male NMRI mice. Physiol Pharmacol 2014; 18 (1) :61-71
URL: http://ppj.phypha.ir/article-1-997-en.html
URL: http://ppj.phypha.ir/article-1-997-en.html
Gholamreza Bagheri Nikoo 
, Maryam Khosravi , Hedayat Sahraei , Mina Ranjbaran , Nahid Sarahian , Homeira Zardooz , Zahra Bourbour , Maryam Alemaref , Gila Pirzad Jhromi , Gholamreza Herfehdoost
, Maryam Khosravi , Hedayat Sahraei , Mina Ranjbaran , Nahid Sarahian , Homeira Zardooz , Zahra Bourbour , Maryam Alemaref , Gila Pirzad Jhromi , Gholamreza Herfehdoost
Abstract: (8843 Views)
Introduction: The brain glutamate system plays a central role in response to stress. This study examines the effect
of memantine (a NMDA glutamate receptor antagonist) on stress from plantar electrical shock in male NMRI mice
(Pasture Institute, Iran), weighing 25-30 g (n=6/group).
Methods: The nucleus accumbens was bilaterally cannulated in a group of animals, and seven days later, different
doses of memantine (1 and 5 μg/mouse) was administered 5 min before inducing stress. In other groups, different doses
of the drug (1 and 5 mg/kg) were administered to the animals intraperitoneally 30 min before the stress induction. Then
food and water intake, anorexia, and the amount of urine and fecal materials were measured.
Results: The stress reduced food intake and increased water intake in the animals. In addition, anorexia, fecal
weight and urine volume were increased dramatically in these animals. Intraperitoneal memantine injection increased
food intake and decreased water intake. This occurred when the drug was administered intra-accumbally, too.
Memantine inhibited stress-induced anorexia when administered either intraperitoneally or intra-accumbally.
Memantine (both peripherally and centrally) also changed stress-induced fecal passage but decreased urination.
Conclusion: Memantine administration can inhibit or potentiate stress effects, which may be at least partially
integrated in the nucleus accumbens.
Type of Manuscript: Experimental research article |
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