TY - JOUR T1 - Effect of esophageal distension on gastric secretions in rat and the possible mechanism TT - JF - Physiol-Pharmacol JO - Physiol-Pharmacol VL - 11 IS - 1 UR - http://ppj.phypha.ir/article-1-380-en.html Y1 - 2007 SP - 60 EP - 67 KW - Esophageal distension KW - Gastric secretions KW - reserpine KW - Vagus nerve KW - Rat. N2 - Introduction: The effect of esophageal distension (ED) on gastric motility has been well documented, but a few investigations have been carried out on the effect of ED on gastric secretion. The aim of this study was to investigate the effect of ED on gastric acid and pepsin secretion and the mechanism(s) involved. Methods: Male adult Wistar rats (200-240 g) were anesthetized with urethane (1.2 g/kg, i.p.) and underwent tracheostomy and laparotomy. A catheter was inserted in the stomach through duodenum for gastric distension and gastric washout. Esophagus was distended by a balloon (0.3 ml, 10 min). Gastric acid secretion was stimulated by gastric distension (by saline 1.5 ml/100 g of B.W.), pentagastrin (20 μg/kg, i.p.) or insulin (0.6 IU/kg, i.p.). Pepsin secretion was stimulated by carbachol (20 μg/kg, i.p.). Effects of cervical vagotomy and reserpine (1 mg/kg, i.p.) were also investigated. Results: Gastric distension-, pentagastrin- and insulin-stimulated gastric acid secretion were decreased by esophageal distension (P M3 ER -