TY - JOUR T1 - Normobaric hyperoxia preconditioning attenuates streptozotocin - induced impairments in spatial learning TT - JF - Physiol-Pharmacol JO - Physiol-Pharmacol VL - 19 IS - 2 UR - http://ppj.phypha.ir/article-1-1087-en.html Y1 - 2015 SP - 130 EP - 138 KW - Alzheimer\'s Disease KW - Streptozotocin KW - Hyperoxia Preconditioning KW - Morris Water Maze KW - Probe test N2 - Introduction: A large body of evidence points to oxidative stress as prime candidate mediating the behavioral impairments and memory deficits in Alzheimer's disease (AD). It has been demonstrated that hyperoxia preconditioning activates complex endogenous neuroprotective mechanisms including an increase in capacity of antioxidant defence mechanisms. The aim of this study was to investigate the beneficial effects of normobaric hyperoxia preconditioning in streptozotocin (STZ)- induced memory impairment in rats. Materials and Methods: Male Wistar rats were first exposed to air with high oxygen concentration (>90%) or atmospheric air for 24 hours and then STZ (3 mg/kg) was bilaterally infused in lateral ventricles of the brain. Two weeks later Morris Water Maze (MWM) test was performed to assess spatial learning and memory consolidation. Results: STZ increased escape latency (P M3 ER -