TY - JOUR T1 - Attenuation of vasoconstrictor response of knee joint blood vessels to (αl- adrenoceptor activation during chronic monoarthritis in rat: The role of nitric oxide TT - کاهش پاسخ دهی عروق زانوی موش صحرایی به تحریک گیرنده های آلفا-1 آدرنرژیک در شرایط التهاب مزمن: نقش نیتریک اوکساید JF - Physiol-Pharmacol JO - Physiol-Pharmacol VL - 4 IS - 2 UR - http://ppj.phypha.ir/article-1-222-en.html Y1 - 2000 SP - 175 EP - 186 KW - Knee joint; Inflammation; αl-adrenoceptor; Nitric oxide; Aminoguanidine; Blood N2 - The effect of chronic inflammation induced by complete Freund's adjuvant (CFA) on anterior blood vessels of knee joint and its diameter was studied. Blood flow changes in response to phenylephrine (αl-adrenoceptor agonist) in CFA-treated and contralateral knee joints were observed over a 40-day period, using laser Doppler flowmetery (LDF) technique. Unilateral injection of CFA (0.2 ml) increased the diameter of injected knee at all days post-injection (p M3 ER -