TY - JOUR JF - Physiol-Pharmacol JO - Physiol Pharmacol VL - 7 IS - 1 PY - 2003 Y1 - 2003/4/01 TI - The effect of ketamine on synaptic transmission and synaptic plasticity in CA1 area of rat hippocampal slices TT - N2 - The effect of ketamine (1-100 µM), which has NMDA receptor antagonist properties, on synaptic transmission and long-term potentiation (LTP) in CAl area of rat hippocampus was examined in vitro. Field potentials were recorded in pyramidal cell layer following Schaffer collateral stimulation. Primed-burst stimulation (PEs) was used for induction of LTP. The amplitude of population spiks (PS) was used as a measure of LTP induction. The results showed that ketamine (1-100 µM) affected baseline synaptic transmission in a concentration-dependent pattern. Furthennore, ketamine application at a high concentration (50-100 µM) for a period of 20-30 min markedly blocked the induction of LTP, whereas lower concentrations of ketamine (1-10 µM) failed to block LTP. However, ketamine at a concentration of 20 µM affected NMDA-mediated LTP induction in a different pattern. It is concluded that the effect of ketamine on baseline synaptic transmission and LTP induced by a l00 Hz PBs depends on ketamine concentration. SP - 13 EP - 27 AU - Fathollahi, Yagoob AU - Rahmati, Batool AU - Semnanian, Saeed AU - Vaez Mahdavi, Mohammad Reza AU - Shafizadeh, Mahshid AD - KW - Ketamine; Synaptic plasticity; Long term potentiation; Hippocampal slice UR - http://ppj.phypha.ir/article-1-424-en.html ER -