AU - Ghotbeddin, Zohre AU - Mirnajafi-Zadeh, Javad AU - Semnanian, Saeed AU - Janahmadi, Mahyar TI - Electrophysiological study of amygdale-induced changes in the excitability of CA1 hippocampal pyramidal neurons in male adult rats PT - JOURNAL ARTICLE TA - Physiol-Pharmacol JN - Physiol-Pharmacol VO - 16 VI - 1 IP - 1 4099 - http://ppj.phypha.ir/article-1-801-en.html 4100 - http://ppj.phypha.ir/article-1-801-en.pdf SO - Physiol-Pharmacol 1 ABĀ  - Introduction: Many studies have shown that amygdala kindling produces synaptic potentiation by induction of changes in the neuronal electrophysiological properties and inward currents both in epileptic focus and in the areas which are in connection with the epileptic focus and have important role in seizure development and progression such as hippocampal CA1 region. However, cellular mechanisms of these processes are not clear. In the present study, changes in the electrophysiological properties of hippocampal CA1 pyramidal neurons following amygdala kindling were examined in rat. Methods: Animals were rapidly kindled by stimulation of right amygdala (12 stimulation per day, 1 ms pulse duration at 50Hz). Twenty-four hours after amygdala kindling, electrophysiological properties and inward currents of CA1 pyramidal neurons were assessed by using whole-cell patch clamp technique. Results: Amygdala kindling findings show that percentage broadening of the last spike compared to the first spike during a trains of action potentials was significantly increased in kindled rats (p CP - IRAN IN - Neuroscience Research Center and Department of Physiology, Medical School, Shahid Beheshti University of Medical Sciences. Evin, Tehran, Iran. PO. Box 19615-1178. LG - eng PB - Physiol-Pharmacol PG - 33 PT - Experimental research article YR - 2012