%0 Journal Article %A Saadat, Habibolah %A Ziai, Seyed ali %A Nasri, Sima %A Sakenshaft, Mina %A Ansarian, Atefe %T Study of the correlation between ACE gene polymorphism and coronary artery disease %J Physiology and Pharmacology %V 13 %N 4 %U http://ppj.phypha.ir/article-1-570-en.html %R %D 2010 %K Angiotensin converting enzyme, Coronary artery disease, CAD, Insertion / deletion polymorphism., %X Introduction: Angiotensin converting enzyme (ACE) is an exopeptidase that converts Angiotensin I to Angiotensin II. Angiotensin II is a potent vasoconstrictor and releases aldosterone, and have a critical role in hypertension. In this study, ACE insertion / deletion (I/D) polymorphism and ACE activity was determined in patients with coronary artery disease (CAD) and normal subjects. The correlation of these parameters with important CAD risk factors were also evaluated. Methods: 204 subjects were assigned to patients and normal groups based on their angiography results. Serum ACE activities were assayed by HPLC and I/D polymorphism were analyzed by PCR method. Important risk factors such as diabetes mellitus, hypertension, lipid profiles, ejection fraction, smoking and opium consumption were also recorded. Results: CAD was higher in DD genotype subjects (OR= 2.45 CI= 1.05-5.73), and ACE activity was about twice in DD compared to II genotypes. ACE activity was higher in hypertensives and diabetics in CAD group (p %> http://ppj.phypha.ir/article-1-570-en.pdf %P 362-370 %& 362 %! %9 Experimental research article %L A-10-368-1 %+ %G eng %@ 24765236 %[ 2010