RT - Journal Article T1 - Study of the correlation between ACE gene polymorphism and coronary artery disease JF - Physiol-Pharmacol YR - 2010 JO - Physiol-Pharmacol VO - 13 IS - 4 UR - http://ppj.phypha.ir/article-1-570-en.html SP - 362 EP - 370 K1 - Angiotensin converting enzyme K1 - Coronary artery disease K1 - CAD K1 - Insertion / deletion polymorphism. AB - Introduction: Angiotensin converting enzyme (ACE) is an exopeptidase that converts Angiotensin I to Angiotensin II. Angiotensin II is a potent vasoconstrictor and releases aldosterone, and have a critical role in hypertension. In this study, ACE insertion / deletion (I/D) polymorphism and ACE activity was determined in patients with coronary artery disease (CAD) and normal subjects. The correlation of these parameters with important CAD risk factors were also evaluated. Methods: 204 subjects were assigned to patients and normal groups based on their angiography results. Serum ACE activities were assayed by HPLC and I/D polymorphism were analyzed by PCR method. Important risk factors such as diabetes mellitus, hypertension, lipid profiles, ejection fraction, smoking and opium consumption were also recorded. Results: CAD was higher in DD genotype subjects (OR= 2.45 CI= 1.05-5.73), and ACE activity was about twice in DD compared to II genotypes. ACE activity was higher in hypertensives and diabetics in CAD group (p LA eng UL http://ppj.phypha.ir/article-1-570-en.html M3 ER -